Ckm MGI Mouse Gene Detail - MGI:88413 - creatine kinase, muscle

Symbol

Ckm
Name

creatine kinase, muscle
Synonyms

Ckmm, M-CK, MCK

Feature Type

protein coding gene
IDs

MGI:88413
NCBI Gene: 12715
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr7:19145019-19155508 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 9.67 cM
Mapping Data

26 experiments

SNPs within 2kb

387 from dbSNP Build 142
Strain Annotations

18
PCR

4
RFLP

5

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88413	protein coding gene	Chr7:19138701-19156766 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031776	protein coding gene	Chr7:17410449-17420972 (+)
A/J	MGP_AJ_G0031752	protein coding gene	Chr7:17057072-17067376 (+)
AKR/J	MGP_AKRJ_G0031678	protein coding gene	Chr7:17529530-17539694 (+)
BALB/cJ	MGP_BALBcJ_G0031757	protein coding gene	Chr7:17258140-17268543 (+)
C3H/HeJ	MGP_C3HHeJ_G0031479	protein coding gene	Chr7:17788855-17800299 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032223	protein coding gene	Chr7:18285978-18296290 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029289	protein coding gene	Chr7:18702580-18713159 (+)
CAST/EiJ	MGP_CASTEiJ_G0030822	protein coding gene	Chr7:14200364-14221287 (+)
CBA/J	MGP_CBAJ_G0031441	protein coding gene	Chr7:18944105-18954627 (+)
DBA/2J	MGP_DBA2J_G0031596	protein coding gene	Chr7:16998927-17009691 (+)
FVB/NJ	MGP_FVBNJ_G0031548	protein coding gene	Chr7:16860962-16871264 (+)
LP/J	MGP_LPJ_G0031679	protein coding gene	Chr7:17733722-17744249 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031584	protein coding gene	Chr7:18802025-18812535 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032251	protein coding gene	Chr7:17127153-17137308 (+)
PWK/PhJ	MGP_PWKPhJ_G0030546	protein coding gene	Chr7:14092591-14103469 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030373	protein coding gene	Chr7:11837761-11850306 (+)
WSB/EiJ	MGP_WSBEiJ_G0030922	protein coding gene	Chr7:17351608-17363401 (+)

Human Ortholog

CKM, creatine kinase, M-type

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CKM, creatine kinase, M-type
Synonyms

CKMM, CPK-M, M-CK
Links

HGNC:1994

NCBI Gene ID: 1158

neXtProt AC: NX_P06732

UniProt: P06732
Chr Location

19q13.32; chr19:45306413-45322875 (-) GRCh38

MGI Vertebrate Homology

Ckm stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CKM
Gene Tree

Ckm

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Phenotype Summary

9 phenotypes from 2 alleles in 1 genetic background
10 phenotypes from multigenic genotypes
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

1
Gene trapped

1
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for disruptions in this gene display abnormalities in function and energy utilization of both skeletal and cardiac muscle.

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All GO Annotations

13
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1086
Tissues

172
cDNA Data

165
Literature Summary

41

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ckm

ZFIN ckma, ckmb

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All Sequences

38
RefSeq

2
UniProt

4
CCDS

CCDS20902.1

Ensembl

ENSMUSG00000030399 (Evidence)
NCBI Gene

12715

			Length	Strain/Species	Flank
genomic	12715	NCBI Gene Model \| MGI Sequence Detail	10490	C57BL/6J	± kb
transcript	NM_007710	RefSeq \| MGI Sequence Detail	1415	ZRU/MplStud
polypeptide	P07310	UniProt \| EBI \| MGI Sequence Detail	381	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005515 creatine kinase M-type

(term hierarchy)
EC

2.7.3.2
InterPro Domains

IPR000749 ATP:guanido phosphotransferase

IPR022415 ATP:guanido phosphotransferase active site

IPR022414 ATP:guanido phosphotransferase, catalytic domain

IPR022413 ATP:guanido phosphotransferase, N-terminal

IPR036802 ATP:guanido phosphotransferase, N-terminal domain superfamily

IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
GlyGen

P07310 1 site, 1 O-linked glycan (1 site)

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All nucleic 185

Genomic 3

cDNA 169

Primer pair 9

Other 4

Microarray probesets 4

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MGD-MRK-2003

Summaries

All 139

Developmental Gene Expression 41

Gene Ontology 10

Phenotypes 37
Earliest

J:7361 Bulfield G, et al., X chromosome-linked muscular dystrophy (mdx) in the mouse. Proc Natl Acad Sci U S A. 1984 Feb;81(4):1189-92
Latest

J:340833 Cai S, et al., KLF4 regulates skeletal muscle development and regeneration by directly targeting P57 and Myomixer. Cell Death Dis. 2023 Sep 18;14(9):612

TSS for Ckm:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr64846	Chr7:19145011-19145026 (+)	0 bp
Tssr64847	Chr7:19148035-19148086 (+)	3,042 bp
Tssr64848	Chr7:19148089-19148096 (+)	3,074 bp
Tssr64849	Chr7:19148112-19148124 (+)	3,099 bp
Tssr64850	Chr7:19148150-19148180 (+)	3,146 bp
Tssr64851	Chr7:19148810-19148821 (+)	3,797 bp
Tssr64852	Chr7:19148856-19148874 (+)	3,846 bp
Tssr2110	Chr7:19148887-19148902 (+)	3,876 bp
Tssr64853	Chr7:19148908-19148933 (+)	3,902 bp
Tssr64854	Chr7:19149324-19149349 (+)	4,318 bp
Tssr64855	Chr7:19149387-19149401 (+)	4,375 bp
Tssr64856	Chr7:19150659-19150685 (+)	5,653 bp
Tssr64857	Chr7:19154082-19154096 (+)	9,070 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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