Clu Gene Detail

Summary

• Symbol
  Clu
• Name
  clusterin
• Synonyms
  ApoJ, Apolipoprotein J, Cli, complement lysis inhibitor, D14Ucla3, Sgp-2, Sgp2, SP-40, Sugp-2, testosterone repressed prostate message-2

• Feature Type
  protein coding gene
• IDs
  MGI:88423
  NCBI Gene: 12759
• Alliance
  gene page
• Transcription Start Sites
  59 TSS

Location &
Maps

• Sequence Map
  Chr14:66206093-66218992 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 14, 34.36 cM
• Mapping Data
  16 experiments

Strain
Comparison

• SNPs within 2kb
  417 from dbSNP Build 142
• Strain Annotations
  18
• RFLP
  4

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88423	protein coding gene	Chr14:66205932-66218996 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021488	protein coding gene	Chr14:60610719-60623779 (+)
A/J	MGP_AJ_G0021447	protein coding gene	Chr14:59192551-59205610 (+)
AKR/J	MGP_AKRJ_G0021423	protein coding gene	Chr14:61245352-61258411 (+)
BALB/cJ	MGP_BALBcJ_G0021453	protein coding gene	Chr14:59134321-59147380 (+)
C3H/HeJ	MGP_C3HHeJ_G0021230	protein coding gene	Chr14:60922990-60938591 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021892	protein coding gene	Chr14:63403013-63416071 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019432	protein coding gene	Chr14:57112529-57125546 (+)
CAST/EiJ	MGP_CASTEiJ_G0020747	protein coding gene	Chr14:57401272-57415815 (+)
CBA/J	MGP_CBAJ_G0021197	protein coding gene	Chr14:65319887-65332964 (+)
DBA/2J	MGP_DBA2J_G0021320	protein coding gene	Chr14:58839524-58852580 (+)
FVB/NJ	MGP_FVBNJ_G0021299	protein coding gene	Chr14:58249960-58263018 (+)
LP/J	MGP_LPJ_G0021395	protein coding gene	Chr14:61650603-61665487 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021328	protein coding gene	Chr14:64396226-64412210 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021915	protein coding gene	Chr14:60446198-60459256 (+)
PWK/PhJ	MGP_PWKPhJ_G0020491	protein coding gene	Chr14:55567043-55580304 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020324	protein coding gene	Chr14:56414688-56429135 (+)
WSB/EiJ	MGP_WSBEiJ_G0020800	protein coding gene	Chr14:60738247-60753374 (+)

Homology

• Human Ortholog
  CLU, clusterin

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  CLU, clusterin
  
• Synonyms
  AAG4, APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2
• Links
  HGNC:2095

  NCBI Gene ID: 1191

  neXtProt AC: NX_P10909

  UniProt: P10909

  
  
• Chr Location
  8p21.1; chr8:27596917-27614700 (-)  GRCh38

---

• MGI Vertebrate Homology
  Clu stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: CLU
• Protein SuperFamily
  Clusterin
• Gene Tree
  Clu
  

Human Diseases

• Diseases
  9 with human CLU associations

				Human Disease	Mouse Models
				atherosclerosis IDs atherosclerosis       DOID:1936 EFO:0003914 ICD10CM:I70 ICD9CM:440 MESH:D050197 NCI:C35768 UMLS_CUI:C0004153
				breast cancer IDs breast cancer       DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				diabetic retinopathy IDs diabetic retinopathy       DOID:8947 ICD9CM:362.0 MESH:D003930 NCI:C34538 UMLS_CUI:C0011884
				exfoliation syndrome IDs exfoliation syndrome       DOID:13641 EFO:0004235 ICD9CM_2006:365.52 ICD9CM:365.52 MESH:D017889 NCI:C129025 OMIM:177650 UMLS_CUI:C0206368
				hypertension IDs hypertension       DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				inclusion body myositis IDs inclusion body myositis       DOID:3429 ICD10CM:G72.41 ICD9CM:359.71 MESH:D018979 NCI:C84786 OMIM:147421 ORDO:611 UMLS_CUI:C0238190
				muscular disease IDs muscular disease       DOID:0080000
				myocardial infarction IDs myocardial infarction       DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				pre-eclampsia IDs pre-eclampsia       DOID:10591 DOID:12684 ICD10CM:O14 MESH:D011225 NCI:C85021 OMIM:189800 OMIM:609402 OMIM:609403 OMIM:609404 OMIM:614592 ORDO:275555 UMLS_CUI:C0032914

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  2 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  24 phenotypes from 2 alleles in 4 genetic backgrounds
  5 phenotypes from multigenic genotypes
  63 phenotype references
  

• All Mutations and Alleles
  17
• Chemically induced (other)
  1
• Endonuclease-mediated
  8
• Gene trapped
  2
• Targeted
  6
• Genomic Mutations
  1 involving Clu
• Incidental Mutations
  APF
• Find Mice (IMSR)
  32 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype
• Recombinase Activity
  Comparison Matrix Gene Expression + Recombinase Activity

Homozygous inactivation of this gene leads to progressive renal glomerulopathy and increased severity of myosin-induced autoimmune myocarditis.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  141
• GO References
  14

Expression

• Assay Results
  1263
• Tissues
  417
• cDNA Data
  576
• Literature Summary
  53

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GENSAT
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA CLU
  Xenbase clu
  ZFIN clu

Sequences &
Gene Models

• All Sequences
  76
• RefSeq
  10
• UniProt
  10
• CCDS
  CCDS36957.1

• Ensembl
  ENSMUSG00000022037 (Evidence)
• NCBI Gene
  12759

Representative Sequences			Length	Strain/Species
genomic	12759	NCBI Gene Model | MGI Sequence Detail	12900	C57BL/6J
transcript	NM_001422221	RefSeq | MGI Sequence Detail	1772	ZRU/MplStud
polypeptide	Q06890	UniProt | EBI | MGI Sequence Detail	448	Not Applicable

Protein
Information

• UniProt
  10 Sequences
• Protein Ontology
  PR:000005615 clusterin
  (term hierarchy)
• InterPro Domains
  IPR016016 Clusterin
  IPR033986 Clusterin, conserved site
  IPR016015 Clusterin, C-terminal
  IPR000753 Clusterin-like
  IPR016014 Clusterin, N-terminal
• GlyGen
  Q06890 8 sites, 10 N-linked glycans (3 sites), 1 O-linked glycan (2 sites)

Molecular
Reagents

• All nucleic 596

  Genomic 4

  cDNA 578

  Primer pair 10

  Other 4

  
  

  Microarray probesets 6

Other
Accession IDs

MGD-MRK-14642, MGD-MRK-2016, MGD-MRK-2022, MGD-MRK-3968, MGI:2145707, MGI:90170

References

• Summaries
  All 205

  Developmental Gene Expression 53

  Diseases 2

  Gene Ontology 14

  Phenotypes 63
• Earliest
  J:17167 Jenne DE, et al., Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid. Proc Natl Acad Sci U S A. 1989 Sep;86(18):7123-7
• Latest
  J:352542 Kirk JS, et al., Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells. Cell Stem Cell. 2024 Jun 14;

TSS for Clu:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126237	Chr14:66205940-66205959 (+)	-143 bp
Tssr126238	Chr14:66205960-66205973 (+)	-126 bp
Tssr126239	Chr14:66205982-66205988 (+)	-108 bp
Tssr126240	Chr14:66205993-66206007 (+)	-93 bp
Tssr126241	Chr14:66206010-66206016 (+)	-80 bp
Tssr126242	Chr14:66206043-66206046 (+)	-48 bp
Tssr126243	Chr14:66206052-66206056 (+)	-39 bp
Tssr126244	Chr14:66206062-66206074 (+)	-25 bp
Tssr126245	Chr14:66206082-66206100 (+)	-2 bp
Tssr126246	Chr14:66206100-66206106 (+)	10 bp
Tssr126247	Chr14:66207163-66207187 (+)	1,082 bp
Tssr126248	Chr14:66207190-66207241 (+)	1,123 bp
Tssr126249	Chr14:66207250-66207270 (+)	1,167 bp
Tssr126250	Chr14:66207977-66207983 (+)	1,887 bp
Tssr126251	Chr14:66208035-66208040 (+)	1,945 bp
Tssr126252	Chr14:66208043-66208058 (+)	1,958 bp
Tssr126253	Chr14:66208059-66208070 (+)	1,972 bp
Tssr126254	Chr14:66208077-66208104 (+)	1,998 bp
Tssr126255	Chr14:66208110-66208118 (+)	2,021 bp
Tssr126256	Chr14:66208333-66208352 (+)	2,250 bp
Tssr126257	Chr14:66208498-66208523 (+)	2,418 bp
Tssr126258	Chr14:66208562-66208602 (+)	2,489 bp
Tssr126259	Chr14:66208613-66208631 (+)	2,529 bp
Tssr126260	Chr14:66209175-66209240 (+)	3,115 bp
Tssr126261	Chr14:66209245-66209257 (+)	3,158 bp
Tssr126262	Chr14:66209266-66209284 (+)	3,182 bp
Tssr126263	Chr14:66210765-66210776 (+)	4,678 bp
Tssr126264	Chr14:66210785-66210817 (+)	4,708 bp
Tssr126265	Chr14:66210826-66210845 (+)	4,743 bp
Tssr126266	Chr14:66210870-66210884 (+)	4,784 bp
Tssr126267	Chr14:66211702-66211711 (+)	5,614 bp
Tssr126268	Chr14:66212286-66212365 (+)	6,233 bp
Tssr126269	Chr14:66212372-66212427 (+)	6,307 bp
Tssr126270	Chr14:66213031-66213042 (+)	6,944 bp
Tssr126271	Chr14:66213049-66213069 (+)	6,966 bp
Tssr126272	Chr14:66213074-66213085 (+)	6,987 bp
Tssr126273	Chr14:66213101-66213108 (+)	7,012 bp
Tssr126274	Chr14:66213145-66213152 (+)	7,056 bp
Tssr126275	Chr14:66213154-66213165 (+)	7,067 bp
Tssr126276	Chr14:66213187-66213247 (+)	7,124 bp
Tssr126277	Chr14:66213252-66213273 (+)	7,170 bp
Tssr126278	Chr14:66213288-66213312 (+)	7,207 bp
Tssr126279	Chr14:66214349-66214373 (+)	8,268 bp
Tssr126280	Chr14:66214379-66214402 (+)	8,298 bp
Tssr126281	Chr14:66217121-66217158 (+)	11,047 bp
Tssr126282	Chr14:66217160-66217172 (+)	11,073 bp
Tssr126283	Chr14:66217173-66217228 (+)	11,108 bp
Tssr126284	Chr14:66217247-66217257 (+)	11,159 bp
Tssr126285	Chr14:66217267-66217287 (+)	11,184 bp
Tssr126286	Chr14:66217293-66217304 (+)	11,206 bp
Tssr4459	Chr14:66218292-66218319 (+)	12,213 bp
Tssr126287	Chr14:66218321-66218341 (+)	12,238 bp
Tssr126288	Chr14:66218350-66218379 (+)	12,272 bp
Tssr4460	Chr14:66218429-66218433 (+)	12,338 bp
Tssr126289	Chr14:66218803-66218820 (+)	12,719 bp
Tssr126290	Chr14:66218823-66218849 (+)	12,743 bp
Tssr126291	Chr14:66218864-66218875 (+)	12,777 bp
Tssr126292	Chr14:66218897-66218927 (+)	12,819 bp
Tssr126293	Chr14:66218937-66218966 (+)	12,859 bp