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Cma2 Gene Detail
Summary
  • Symbol
    Cma2
  • Name
    chymase 2, mast cell
  • Feature Type
    protein coding gene
  • IDs
    MGI:88426
    NCBI Gene: 545055
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr14:56188437-56211488 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM, cytoband C1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    747 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88426
 protein coding gene Chr14:56188437-56211488 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021382
 protein coding gene Chr14:50136554-50139055 (-)
A/J MGP_AJ_G0021341
 protein coding gene Chr14:49135674-49138034 (-)
AKR/J MGP_AKRJ_G0021317
 protein coding gene Chr14:50904899-50907400 (-)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0021125
 protein coding gene Chr14:50582630-50585991 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021784
 protein coding gene Chr14:52662367-52664311 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0020644
 protein coding gene Chr14:46867343-46870970 (-)
CBA/J MGP_CBAJ_G0021092
 protein coding gene Chr14:54206625-54209118 (-)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0021195
 protein coding gene Chr14:48286571-48289073 (-)
LP/J MGP_LPJ_G0021287
 protein coding gene Chr14:51184714-51188614 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021219
 protein coding gene Chr14:53558363-53562149 (-)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0020218
 protein coding gene Chr14:46139473-46141365 (-)
WSB/EiJ MGP_WSBEiJ_G0020697
 protein coding gene Chr14:50347616-50350116 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 545055 NCBI Gene Model | MGI Sequence Detail 23052 C57BL/6J ±  kb
transcript NM_001024714 RefSeq | MGI Sequence Detail 983 C57BL/6  
polypeptide NP_001019885 RefSeq | MGI Sequence Detail 246 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-2026
References
more
  • Summaries
    All 17
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:1144 Chu W, et al., Molecular cloning and characterization of mouse mast cell chymases. Biochim Biophys Acta. 1992 May 22;1121(1-2):83-7
  • Latest
    J:102936 Lee M, et al., Mast cell chymase degrades apoE and apoA-II in apoA-I-knockout mouse plasma and reduces its ability to promote cellular cholesterol efflux. Arterioscler Thromb Vasc Biol. 2002 Sep 1;22(9):1475-81
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory