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Cnbp Gene Detail
Summary
  • Symbol
    Cnbp
  • Name
    cellular nucleic acid binding protein
  • Synonyms
    Znf9
  • Feature Type
    protein coding gene
  • IDs
    MGI:88431
    NCBI Gene: 12785
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:87819597-87828088 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 39.13 cM, cytoband D1-D2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    195 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88431
 protein coding gene Chr6:87819597-87828088 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031001
 protein coding gene Chr6:89215244-89223737 (-)
A/J MGP_AJ_G0030967
 protein coding gene Chr6:85769497-85778190 (-)
AKR/J MGP_AKRJ_G0030898
 protein coding gene Chr6:88245574-88254067 (-)
BALB/cJ MGP_BALBcJ_G0030980
 protein coding gene Chr6:85762358-85770901 (-)
C3H/HeJ MGP_C3HHeJ_G0030730
 protein coding gene Chr6:96214721-96223215 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031437
 protein coding gene Chr6:91601842-91610332 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028620
 protein coding gene Chr6:83940494-83950390 (-)
CAST/EiJ MGP_CASTEiJ_G0030089
 protein coding gene Chr6:88329459-88338689 (-)
CBA/J MGP_CBAJ_G0030664
 protein coding gene Chr6:95150670-95159163 (-)
DBA/2J MGP_DBA2J_G0030820
 protein coding gene Chr6:85066984-85075749 (-)
FVB/NJ MGP_FVBNJ_G0030773
 protein coding gene Chr6:84257236-84265724 (-)
LP/J MGP_LPJ_G0030897
 protein coding gene Chr6:89230429-89238925 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030806
 protein coding gene Chr6:99280401-99288898 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031464
 protein coding gene Chr6:88100984-88109481 (-)
PWK/PhJ MGP_PWKPhJ_G0029804
 protein coding gene Chr6:84035594-84044197 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029632
 protein coding gene Chr6:86913920-86922357 (-)
WSB/EiJ MGP_WSBEiJ_G0030170
 protein coding gene Chr6:88551459-88559936 (-)



Homology
more
  • Human Ortholog
    CNBP, CCHC-type zinc finger nucleic acid binding protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNBP, CCHC-type zinc finger nucleic acid binding protein
  • Synonyms
    CNBP1, DM2, PROMM, RNF163, ZCCHC22, ZNF9
  • Links
    NCBI Gene ID: 7555
    neXtProt AC: NX_P62633
    UniProt: P62633

  • Chr Location
    3q21.3; chr3:129167827-129183922 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CNBP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a retroviral insertion die around E10.5 showing abnormal anterior visceral endoderm formation, reduced embryonic neuroepithelial cell proliferation, lack of anterior definitive endoderm and anterior neuroectoderm, absent diencephalon and telencephalon, and forebrain truncation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1022
  • Tissues
    241
  • cDNA Data
    35
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12785 NCBI Gene Model | MGI Sequence Detail 8492 C57BL/6J ±  kb
    transcript NM_013493 RefSeq | MGI Sequence Detail 2178 C57BL/6  
    polypeptide P53996 UniProt | EBI | MGI Sequence Detail 178 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000005627 CCHC-type zinc finger nucleic acid binding protein
      (term hierarchy)
    • InterPro Domains
      IPR051714 CCHC-type Zinc Finger Nucleic Acid Binding
      IPR001878 Zinc finger, CCHC-type
      IPR036875 Zinc finger, CCHC-type superfamily
    • GlyGen
      P53996 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 1
      cDNA 36
      Primer pair 3
      Other 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-2033, MGI:2141361
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 21
      Gene Ontology 7
      Phenotypes 24
    • Earliest
      J:21465 Warden CH, et al., Mouse cellular nucleic acid binding proteins: a highly conserved family identified by genetic mapping and sequencing. Genomics. 1994 Nov 1;24(1):14-9
    • Latest
      J:347749 Pereira M, et al., The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection. Cell Rep. 2024 Feb 27;43(2):113795
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory