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Col10a1 Gene Detail
Summary
  • Symbol
    Col10a1
  • Name
    collagen, type X, alpha 1
  • Synonyms
    Col10, Col10a-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88445
    NCBI Gene: 12813
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:34265977-34273081 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 18.85 cM, cytoband B1-B3
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    236 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88445
 protein coding gene Chr10:34265977-34273081 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017141
 protein coding gene Chr10:32736313-32743417 (+)
A/J MGP_AJ_G0017118
 protein coding gene Chr10:31892085-31899165 (+)
AKR/J MGP_AKRJ_G0017078
 protein coding gene Chr10:32270053-32277150 (+)
BALB/cJ MGP_BALBcJ_G0017081
 protein coding gene Chr10:31826116-31833220 (+)
C3H/HeJ MGP_C3HHeJ_G0016901
 protein coding gene Chr10:32560839-32567927 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017539
 protein coding gene Chr10:33678550-33685616 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015236
 protein coding gene Chr10:30204825-30211880 (+)
CAST/EiJ MGP_CASTEiJ_G0016480
 protein coding gene Chr10:32681695-32688730 (+)
CBA/J MGP_CBAJ_G0016875
 protein coding gene Chr10:35309943-35317021 (+)
DBA/2J MGP_DBA2J_G0016980
 protein coding gene Chr10:31456722-31464316 (+)
FVB/NJ MGP_FVBNJ_G0016975
 protein coding gene Chr10:30978179-30985259 (+)
LP/J MGP_LPJ_G0017057
 protein coding gene Chr10:32734490-32741582 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017005
 protein coding gene Chr10:35774534-35781600 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017575
 protein coding gene Chr10:32212593-32219697 (+)
PWK/PhJ MGP_PWKPhJ_G0016261
 protein coding gene Chr10:31233238-31240449 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016045
 protein coding gene Chr10:32080955-32087980 (+)
WSB/EiJ MGP_WSBEiJ_G0016543
 protein coding gene Chr10:32418800-32425910 (+)



Homology
more
  • Human Ortholog
    COL10A1, collagen type X alpha 1 chain
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COL10A1, collagen type X alpha 1 chain
  • Links
    NCBI Gene ID: 1300
    neXtProt AC: NX_Q03692
    UniProt: Q03692

  • Chr Location
    6q22.1; chr6:116118909-116217144 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Col10a1 mouse models; 2 with human COL10A1 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 4 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    5 images
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations may exhibit abnormal trabecular bone, thinner growth plate resting zone and articular cartilage, and altered bone content. Mice homozygous for another knock-out allele exhibit altered B and T cell populations and TH1/TH2responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1452
  • Tissues
    189
  • cDNA Data
    29
  • Literature Summary
    510
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12813 NCBI Gene Model | MGI Sequence Detail 7105 C57BL/6J ±  kb
    transcript NM_009925 RefSeq | MGI Sequence Detail 3139 ZRU/MplStud  
    polypeptide Q05306 UniProt | EBI | MGI Sequence Detail 680 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 121
      Genomic 21
      cDNA 39
      Primer pair 14
      Other 47

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2051, MGD-MRK-2052
    References
    more
    • Summaries
      All 592
      Developmental Gene Expression 510
      Diseases 2
      Gene Ontology 14
      Phenotypes 38
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:355649 Li Q, et al., Metabolic rewiring during bone development underlies tRNA m7G-associated primordial dwarfism. J Clin Invest. 2024 Sep 10;134(20)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory