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Col3a1
Gene Detail
Symbol

Name
ID
Col3a1
collagen, type III, alpha 1
MGI:88453
Synonyms
Col3a-1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
23.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr1:45311538-45349706 bp, + strand
From VEGA annotation of GRCm38

  38169 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55433  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 western clawed frog

Gene Tree: Col3a1

Human
homologs
Human Homolog COL3A1, collagen, type III, alpha 1
NCBI Gene ID 1281
neXtProt AC  NX_P02461
Human Synonyms  EDS4A
Human Chr (Location)  2q31; chr2:188974373-189012746 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human COL3A1
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Most homozygous mutants die within 48 hours after birth. Surviving mutants have reduced body size, skin lesions, enlarged intestines, and die by 6 months of age from ruptured blood vessels. Occasionally intestinal rupture also results in early death.
 
Human Diseases Modeled Using Mouse Col3a1 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(3)
Interactions
Col3a1 interacts with 234 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (54 records)
Data Summary: Results (431)    Tissues (186)    Images (65)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 16
RNA in situ 405
RT-PCR 10
cDNA source data(1136)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(1148) Genomic(6) cDNA(1138) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021335 (Evidence)
Ensembl Gene ModelENSMUSG00000026043 (Evidence)
Entrez Gene12825 (Evidence)
UniGene249555
DFCITC1573630, TC1617397, TC1664840, TC1727621
DoTSDT.101184276, DT.101242375, DT.101406451, DT.87042571, DT.94332183, DT.94354293, DT.99867153
NIA Mouse Gene IndexU000236
Consensus CDS ProjectCCDS35554.1
International Mouse Knockout Project StatusCol3a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021335 VEGA Gene Model | MGI Sequence Detail 38169 C57BL/6J ±  kb
transcript OTTMUST00000050577 VEGA | MGI Sequence Detail 5564 Not Applicable 
polypeptide OTTMUSP00000023637 VEGA | MGI Sequence Detail 1464 Not Applicable 

For the selected sequences
All sequences(92) RefSeq(2) UniProt(25)
Polymorphisms
RFLP(4) : SNPs within 2kb(263 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR000885 Fibrillar collagen, C-terminal
InterPro IPR001007 von Willebrand factor, type C
Protein Ontology PR:000003328 collagen alpha-1(III) chain
References
(Earliest) J:20241 Liau G, et al., Coordinate regulation of the levels of type III and type I collagen mRNA in most but not all mouse fibroblasts. J Biol Chem. 1985 Jan 10;260(1):531-6
(Latest) J:213088 Soteriou D, et al., Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J Biol Chem. 2013 Jun 28;288(26):18716-31
All references(119)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-2064, MGD-MRK-2065, MGI:2138608

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory