Cox5b MGI Mouse Gene Detail - MGI:88475 - cytochrome c oxidase subunit 5B

Symbol

Cox5b
Name

cytochrome c oxidase subunit 5B

Feature Type

protein coding gene
IDs

MGI:88475
NCBI Gene: 12859
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:36730568-36732469 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 15.38 cM
Mapping Data

1 experiment

SNPs within 2kb

153 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88475	protein coding gene	Chr1:36730530-36732762 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015930	protein coding gene	Chr1:35242115-35246485 (+)
A/J	MGP_AJ_G0015914	protein coding gene	Chr1:34292485-34295264 (+)
AKR/J	MGP_AKRJ_G0015869	protein coding gene	Chr1:34771554-34773749 (+)
BALB/cJ	MGP_BALBcJ_G0015868	protein coding gene	Chr1:33980468-33983919 (+)
C3H/HeJ	MGP_C3HHeJ_G0015701	protein coding gene	Chr1:34978740-34980937 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016321	protein coding gene	Chr1:36827769-36829966 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014043	protein coding gene	Chr1:31345508-31347626 (+)
CAST/EiJ	MGP_CASTEiJ_G0015282	protein coding gene	Chr1:34859715-34861944 (+)
CBA/J	MGP_CBAJ_G0015673	protein coding gene	Chr1:37805598-37807794 (+)
DBA/2J	MGP_DBA2J_G0015774	protein coding gene	Chr1:33628161-33630472 (+)
FVB/NJ	MGP_FVBNJ_G0015776	protein coding gene	Chr1:33149633-33152527 (+)
LP/J	MGP_LPJ_G0015844	protein coding gene	Chr1:35611268-35613465 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015796	protein coding gene	Chr1:40007692-40009889 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016368	protein coding gene	Chr1:34816432-34820698 (+)
PWK/PhJ	MGP_PWKPhJ_G0015065	protein coding gene	Chr1:33381848-33385046 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014848	protein coding gene	Chr1:34767902-34769739 (+)
WSB/EiJ	MGP_WSBEiJ_G0015344	protein coding gene	Chr1:34771588-34773784 (+)

Human Ortholog

COX5B, cytochrome c oxidase subunit 5B

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COX5B, cytochrome c oxidase subunit 5B
Synonyms

COXVB
Links

HGNC:2269

NCBI Gene ID: 1329

neXtProt AC: NX_P10606

UniProt: P10606
Chr Location

2q11.2; chr2:97646062-97648383 (+) GRCh38

MGI Vertebrate Homology

Cox5b stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: COX5B
Gene Tree

Cox5b

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Gene trapped

3
Targeted

4
Genomic Mutations

1 involving Cox5b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

831
Tissues

108
cDNA Data

6
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cox5b, cox5b.2

ZFIN cox5bb

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All Sequences

44
RefSeq

2
UniProt

1
CCDS

CCDS14886.1

Ensembl

ENSMUSG00000061518 (Evidence)
NCBI Gene

12859

			Length	Strain/Species	Flank
genomic	12859	NCBI Gene Model \| MGI Sequence Detail	1902	C57BL/6J	± kb
transcript	NM_009942	RefSeq \| MGI Sequence Detail	584	C57BL/6
polypeptide	P19536	UniProt \| EBI \| MGI Sequence Detail	128	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005780 cytochrome c oxidase subunit 5B, mitochondrial

(term hierarchy)

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All nucleic 13

Genomic 5

cDNA 6

Primer pair 2

Microarray probesets 6

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MGD-MRK-2099

Summaries

All 59

Developmental Gene Expression 13

Gene Ontology 12

Phenotypes 12
Earliest

J:10015 Nielsen PJ, et al., Nucleotide sequence of cDNA encoding mouse cytochrome c oxidase subunit Va. Nucleic Acids Res. 1989 Aug 25;17(16):6723
Latest

J:355679 Vercellino I, et al., SCAF1 drives the compositional diversity of mammalian respirasomes. Nat Struct Mol Biol. 2024 Jul;31(7):1061-1071

TSS for Cox5b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6272	Chr1:36730611-36730635 (+)	55 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24