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Cp Gene Detail
Summary
  • Symbol
    Cp
  • Name
    ceruloplasmin
  • Synonyms
    D3Ertd555e
  • Feature Type
    protein coding gene
  • IDs
    MGI:88476
    NCBI Gene: 12870
  • Alliance
    gene page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:20011218-20063309 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 6.10 cM, cytoband D
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1761 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88476
 protein coding gene Chr3:20011097-20063914 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027097
 protein coding gene Chr3:17161773-17213417 (+)
A/J MGP_AJ_G0027057
 protein coding gene Chr3:17082181-17136846 (+)
AKR/J MGP_AKRJ_G0027026
 protein coding gene Chr3:17249899-17302819 (+)
BALB/cJ MGP_BALBcJ_G0027069
 protein coding gene Chr3:16837418-16890203 (+)
C3H/HeJ MGP_C3HHeJ_G0026810
 protein coding gene Chr3:17273879-17328338 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027514
 protein coding gene Chr3:18241816-18302448 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024876
 protein coding gene Chr3:15149996-15201795 (+)
CAST/EiJ MGP_CASTEiJ_G0026265
 protein coding gene Chr3:17181670-17237920 (+)
CBA/J MGP_CBAJ_G0026788
 protein coding gene Chr3:18646814-18704207 (+)
DBA/2J MGP_DBA2J_G0026922
 protein coding gene Chr3:16702375-16756158 (+)
FVB/NJ MGP_FVBNJ_G0026890
 protein coding gene Chr3:16358085-16412938 (+)
LP/J MGP_LPJ_G0027034
 protein coding gene Chr3:17813964-17867144 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026911
 protein coding gene Chr3:20721753-20778709 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027574
 protein coding gene Chr3:17039649-17095498 (+)
PWK/PhJ MGP_PWKPhJ_G0025998
 protein coding gene Chr3:16397306-16452306 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025807
 protein coding gene Chr3:16837239-16896461 (+)
WSB/EiJ MGP_WSBEiJ_G0026338
 protein coding gene Chr3:17039453-17100319 (+)



Homology
more
  • Human Ortholog
    CP, ceruloplasmin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CP, ceruloplasmin
  • Synonyms
    AB073614, CP-2
  • Links
    NCBI Gene ID: 1356
    neXtProt AC: NX_P00450
    UniProt: P00450

  • Chr Location
    3q24-q25.1; chr3:149162410-149221829 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cp mouse models; 3 with human CP associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 6 alleles in 7 genetic backgrounds
    20 phenotypes from multigenic genotypes
    4 images
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit progressive accumulation of stored iron in the liver, spleen, cerebellum, and brainstem, mild iron deficiency anemia, and impaired motor coordination associated with loss of brainstem dopaminergic neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    997
  • Tissues
    180
  • cDNA Data
    386
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003617 Ensembl Gene Model | MGI Sequence Detail 52092 C57BL/6J ±  kb
    transcript ENSMUST00000108329 Ensembl | MGI Sequence Detail 4564 Not Applicable  
    polypeptide ENSMUSP00000103965 Ensembl | MGI Sequence Detail 1086 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 394
      Genomic 3
      cDNA 387
      Primer pair 4

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-2100, MGI:1261828
    References
    more
    • Summaries
      All 110
      Developmental Gene Expression 11
      Diseases 6
      Gene Ontology 9
      Phenotypes 63
    • Earliest
      J:7811 Baranov VS, et al., [Mapping of the ceruloplasmin gene on human and laboratory mouse chromosomes by direct in situ hybridization]. Genetika. 1985 Mar;21(3):409-19
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory