Crabp2 MGI Mouse Gene Detail - MGI:88491 - cellular retinoic acid binding protein II

Symbol

Crabp2
Name

cellular retinoic acid binding protein II
Synonyms

Crabp-2, CrabpII

Feature Type

protein coding gene
IDs

MGI:88491
NCBI Gene: 12904
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:87856000-87860679 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 38.78 cM
Mapping Data

3 experiments

SNPs within 2kb

184 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88491	protein coding gene	Chr3:87855973-87860683 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027376	protein coding gene	Chr3:88081869-88086575 (+)
A/J	MGP_AJ_G0027340	protein coding gene	Chr3:85091792-85096503 (+)
AKR/J	MGP_AKRJ_G0027306	protein coding gene	Chr3:87184993-87189715 (+)
BALB/cJ	MGP_BALBcJ_G0027349	protein coding gene	Chr3:85186040-85190766 (+)
C3H/HeJ	MGP_C3HHeJ_G0027092	protein coding gene	Chr3:87455623-87460319 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027795	protein coding gene	Chr3:91323265-91327975 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025148	protein coding gene	Chr3:80714763-80719483 (+)
CAST/EiJ	MGP_CASTEiJ_G0026538	protein coding gene	Chr3:87665702-87672508 (+)
CBA/J	MGP_CBAJ_G0027067	protein coding gene	Chr3:94414025-94418756 (+)
DBA/2J	MGP_DBA2J_G0027203	protein coding gene	Chr3:84582824-84587542 (+)
FVB/NJ	MGP_FVBNJ_G0027172	protein coding gene	Chr3:82855539-82860250 (+)
LP/J	MGP_LPJ_G0027311	protein coding gene	Chr3:89047917-89052620 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027191	protein coding gene	Chr3:100659952-100664694 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027853	protein coding gene	Chr3:86940379-86944905 (+)
PWK/PhJ	MGP_PWKPhJ_G0026271	protein coding gene	Chr3:84378481-84383390 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026089	protein coding gene	Chr3:86120587-86125306 (+)
WSB/EiJ	MGP_WSBEiJ_G0026618	protein coding gene	Chr3:87298805-87304330 (+)

Human Ortholog

CRABP2, cellular retinoic acid binding protein 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRABP2, cellular retinoic acid binding protein 2
Synonyms

CRABP-II, RBP6
Links

HGNC:2339

NCBI Gene ID: 1382

neXtProt AC: NX_P29373

UniProt: P29373
Chr Location

1q23.1; chr1:156699606-156705816 (-) GRCh38

MGI Vertebrate Homology

Crabp2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CRABP2
Gene Tree

Crabp2

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 3 alleles in 3 genetic backgrounds
3 phenotypes from multigenic genotypes
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

4
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Crabp2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations may exhibit an additional postaxial digit, usually on a single forepaw. Penetrance is dependent on the genetic background.

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All GO Annotations

22
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1471
Tissues

351
cDNA Data

68
Literature Summary

59

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase crabp2

ZFIN crabp2a, crabp2b

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All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS17460.1

Ensembl

ENSMUSG00000004885 (Evidence)
NCBI Gene

12904

			Length	Strain/Species	Flank
genomic	12904	NCBI Gene Model \| MGI Sequence Detail	4680	C57BL/6J	± kb
transcript	NM_007759	RefSeq \| MGI Sequence Detail	900	C57BL/6
polypeptide	P22935	UniProt \| EBI \| MGI Sequence Detail	138	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005844 cellular retinoic acid-binding protein 2

(term hierarchy)
InterPro Domains

IPR012674 Calycin

IPR000463 Cytosolic fatty-acid binding

IPR031259 Intracellular lipid binding protein

IPR000566 Lipocalin/cytosolic fatty-acid binding domain

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All nucleic 83

Genomic 1

cDNA 70

Primer pair 9

Other 3

Microarray probesets 3

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MGD-MRK-2127, MGD-MRK-2129, MGI:2139840

Summaries

All 114

Developmental Gene Expression 59

Diseases 1

Gene Ontology 11

Phenotypes 20
Earliest

J:20074 Giguere V, et al., Molecular cloning of cDNA encoding a second cellular retinoic acid-binding protein. Proc Natl Acad Sci U S A. 1990 Aug;87(16):6233-7
Latest

J:350500 Kibalnyk Y, et al., The chromatin regulator Ankrd11 controls cardiac neural crest cell-mediated outflow tract remodeling and heart function. Nat Commun. 2024 Jul 1;15(1):4632

TSS for Crabp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29874	Chr3:87855994-87856011 (+)	3 bp
Tssr29875	Chr3:87859839-87859862 (+)	3,851 bp
Tssr29876	Chr3:87860353-87860363 (+)	4,358 bp
Tssr29877	Chr3:87860369-87860378 (+)	4,374 bp
Tssr29878	Chr3:87860392-87860404 (+)	4,398 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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