Crp MGI Mouse Gene Detail - MGI:88512 - C-reactive protein, pentraxin-related

Symbol

Crp
Name

C-reactive protein, pentraxin-related

Feature Type

protein coding gene
IDs

MGI:88512
NCBI Gene: 12944
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:172525623-172527533 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 80.13 cM
Mapping Data

21 experiments

SNPs within 2kb

83 from dbSNP Build 142
Strain Annotations

18
PCR

6
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88512	protein coding gene	Chr1:172525622-172660598 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016796	protein coding gene	Chr1:178580548-178709171 (+)
A/J	MGP_AJ_G0016775	protein coding gene	Chr1:171283694-171409695 (+)
AKR/J	MGP_AKRJ_G0016741	protein coding gene	Chr1:176444800-176587753 (+)
BALB/cJ	MGP_BALBcJ_G0016736	protein coding gene	Chr1:171812837-171949194 (+)
C3H/HeJ	MGP_C3HHeJ_G0016560	protein coding gene	Chr1:177021906-177162309 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017198	protein coding gene	Chr1:184503508-184648850 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014904	protein coding gene	Chr1:162970773-163091722 (+)
CAST/EiJ	MGP_CASTEiJ_G0016140	protein coding gene	Chr1:176388315-176523062 (+)
CBA/J	MGP_CBAJ_G0016534	protein coding gene	Chr1:191075957-191230022 (+)
DBA/2J	MGP_DBA2J_G0016641	protein coding gene	Chr1:170203788-170333747 (+)
FVB/NJ	MGP_FVBNJ_G0016638	protein coding gene	Chr1:168459799-168578357 (+)
LP/J	MGP_LPJ_G0016712	protein coding gene	Chr1:179654166-179783126 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016665	protein coding gene	Chr1:198291351-198432181 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017234	protein coding gene	Chr1:176326480-176484866 (+)
PWK/PhJ	MGP_PWKPhJ_G0015926	protein coding gene	Chr1:169588699-169720531 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015708	protein coding gene	Chr1:175286523-175423466 (+)
WSB/EiJ	MGP_WSBEiJ_G0016202	protein coding gene	Chr1:176479767-176608749 (+)

Human Ortholog

CRP, C-reactive protein

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRP, C-reactive protein
Synonyms

PTX1
Links

HGNC:2367

NCBI Gene ID: 1401

neXtProt AC: NX_P02741

UniProt: P02741
Chr Location

1q23.2; chr1:159712289-159714589 (-) GRCh38

MGI Vertebrate Homology

Crp stringent orthology
1 human;1 mouse;1 rat;5 zebrafish
HCOP

vertebrate homology predictions: CRP
Gene Tree

Crp

Diseases

15 with human CRP associations

				Human Disease	Mouse Models
				acute kidney failure IDs acute kidney failure DOID:3021 MESH:D058186
				antiphospholipid syndrome IDs antiphospholipid syndrome DOID:2988 ICD10CM:D68.61 MESH:D016736 NCI:C61283 OMIM:107320 UMLS_CUI:C0085278
				heart disease IDs heart disease DOID:114 ICD10CM:I51.9 ICD9CM:429.9 MESH:D006331 NCI:C3079 UMLS_CUI:C0018799
				human immunodeficiency virus infectious disease IDs human immunodeficiency virus infectious disease DOID:526 ICD10CM:B20 ICD9CM:042 ICD9CM:042-042.99 MESH:D015658 NCI:C3108 UMLS_CUI:C0019693
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				inflammatory bowel disease IDs inflammatory bowel disease DOID:0050589 EFO:0003767 KEGG:05321 MESH:D015212 NCI:C3138 OMIM:PS266600 UMLS_CUI:C0021390
				interstitial nephritis IDs interstitial nephritis DOID:1063 ICD10CM:N12 MESH:D009395 NCI:C26834 UMLS_CUI:C0027707
				Kawasaki disease IDs Kawasaki disease DOID:13378 EFO:0004246 ICD10CM:M30.3 ICD9CM_2006:446.1 ICD9CM:446.1 MESH:D009080 NCI:C34825 OMIM:611775 UMLS_CUI:C0026691
				Kuhnt-Junius degeneration IDs Kuhnt-Junius degeneration DOID:10873 ICD10CM:H35.32 ICD9CM_2006:362.52 ICD9CM:362.52 UMLS_CUI:C0271084
				lupus nephritis IDs lupus nephritis DOID:0080162 MESH:D008181
				macular degeneration IDs macular degeneration DOID:4448 MESH:D008268 NCI:C123330 ORDO:279 UMLS_CUI:C0024437
				middle cerebral artery infarction IDs middle cerebral artery infarction DOID:3525 MESH:D020244 UMLS_CUI:C0740392
				obstructive sleep apnea IDs obstructive sleep apnea DOID:0050848 ICD10CM:G47.33 ICD9CM:327.23 ICD9CM:780.57 MESH:D020181 NCI:C116337 OMIM:107650 UMLS_CUI:C0520679
				renal fibrosis IDs renal fibrosis DOID:0050855
				systemic lupus erythematosus IDs systemic lupus erythematosus DOID:9074 ICD10CM:M32.9 ICD9CM:710.0 KEGG:05322 MESH:D008180 NCI:C3201 OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 ORDO:536 UMLS_CUI:C0024141

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotypes from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

2
Endonuclease-mediated

6
Targeted

3
Genomic Mutations

2 involving Crp
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele lack detectable C-reactive protein in the serum but are otherwise healthy and fertile. Mice homozgyous for another null allele exhibit increased acetaminophen-induced liver injury and lethality.

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All GO Annotations

43
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

3
cDNA Data

32
Literature Summary

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase crp, crp.1, crp.2, crp.4

ZFIN crp5

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All Sequences

34
RefSeq

2
UniProt

3
CCDS

CCDS35787.1

Ensembl

ENSMUSG00000037942 (Evidence)
NCBI Gene

12944

			Length	Strain/Species	Flank
genomic	12944	NCBI Gene Model \| MGI Sequence Detail	1911	C57BL/6J	± kb
transcript	NM_007768	RefSeq \| MGI Sequence Detail	1698	Not Specified
polypeptide	P14847	UniProt \| EBI \| MGI Sequence Detail	225	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005897 C-reactive protein

(term hierarchy)
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR030476 Pentaxin, conserved site

IPR051005 Pentraxin domain-containing protein

IPR001759 Pentraxin-related

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All nucleic 60

Genomic 21

cDNA 34

Primer pair 5

Microarray probesets 3

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MGD-MRK-2156, MGI:2138184

Summaries

All 94

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 11
Earliest

J:129706 Ciliberto G, et al., Inducible and tissue-specific expression of human C-reactive protein in transgenic mice. EMBO J. 1987 Dec 20;6(13):4017-22
Latest

J:341215 Fu Y, et al., C-reactive protein deficiency ameliorates experimental abdominal aortic aneurysms. Front Immunol. 2023;14:1233807

TSS for Crp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10246	Chr1:172525613-172525630 (+)	-1 bp
Tssr10247	Chr1:172526556-172526578 (+)	944 bp
Tssr10248	Chr1:172526622-172526633 (+)	1,005 bp
Tssr10249	Chr1:172526646-172526661 (+)	1,031 bp
Tssr10250	Chr1:172526701-172526713 (+)	1,084 bp
Tssr10251	Chr1:172526757-172526767 (+)	1,139 bp
Tssr10252	Chr1:172526823-172526828 (+)	1,203 bp
Tssr10253	Chr1:172526872-172526883 (+)	1,255 bp
Tssr10254	Chr1:172526937-172526946 (+)	1,319 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24