Cs MGI Mouse Gene Detail - MGI:88529

Symbol

Cs
Name

citrate synthase
Synonyms

2610511A05Rik, 9030605P22Rik, ahl4, Cis

Feature Type

protein coding gene
IDs

MGI:88529
NCBI Gene: 12974
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:128173603-128198348 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 76.53 cM
Mapping Data

5 experiments

SNPs within 2kb

545 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88529	protein coding gene	Chr10:128173596-128198351 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017860	protein coding gene	Chr10:132061214-132090618 (+)
A/J	MGP_AJ_G0017835	protein coding gene	Chr10:126762799-126788641 (+)
AKR/J	MGP_AKRJ_G0017798	protein coding gene	Chr10:130487867-130512569 (+)
BALB/cJ	MGP_BALBcJ_G0017799	protein coding gene	Chr10:127147098-127171607 (+)
C3H/HeJ	MGP_C3HHeJ_G0017622	protein coding gene	Chr10:130650876-130675925 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018254	protein coding gene	Chr10:136543302-136570710 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015932	protein coding gene	Chr10:120700667-120725286 (+)
CAST/EiJ	MGP_CASTEiJ_G0017183	protein coding gene	Chr10:131355806-131381602 (+)
CBA/J	MGP_CBAJ_G0017592	protein coding gene	Chr10:142088086-142117786 (+)
DBA/2J	MGP_DBA2J_G0017698	protein coding gene	Chr10:125823814-125849195 (+)
FVB/NJ	MGP_FVBNJ_G0017693	protein coding gene	Chr10:124752408-124778934 (+)
LP/J	MGP_LPJ_G0017772	protein coding gene	Chr10:132657673-132686988 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017721	protein coding gene	Chr10:144670757-144706901 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018294	protein coding gene	Chr10:130584088-130611287 (+)
PWK/PhJ	MGP_PWKPhJ_G0016968	protein coding gene	Chr10:126084590-126109568 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016757	protein coding gene	Chr10:129679388-129705427 (+)
WSB/EiJ	MGP_WSBEiJ_G0017242	protein coding gene	Chr10:130799772-130825559 (+)

Human Ortholog

CS, citrate synthase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CS, citrate synthase
Links

HGNC:2422

NCBI Gene ID: 1431

neXtProt AC: NX_O75390

UniProt: O75390
Chr Location

12q13.3; chr12:56271699-56300391 (-) GRCh38

MGI Vertebrate Homology

Cs stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CS
Gene Tree

Cs

Diseases

2 with human CS associations

				Human Disease	Mouse Models
				dilated cardiomyopathy IDs dilated cardiomyopathy DOID:12930 EFO:0000407 ICD10CM:I42.0 KEGG:05414 MESH:D002311 NCI:C84673 OMIM:PS115200 ORDO:217604 UMLS_CUI:C0007193
				hypertrophic cardiomyopathy IDs hypertrophic cardiomyopathy DOID:11984 DOID:11986 ICD9CM:425.1 ICD9CM:425.11 KEGG:05410 MESH:D002312 NCI:C34449 ORDO:217569 UMLS_CUI:C0007194

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 2 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

38
Endonuclease-mediated

3
Gene trapped

32
Spontaneous

1
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a point mutation exhibit hearing loss.

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All GO Annotations

24
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

849
Tissues

107
cDNA Data

14
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cs

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All Sequences

51
RefSeq

4
UniProt

2
CCDS

CCDS24273.1

Ensembl

ENSMUSG00000005683 (Evidence)
NCBI Gene

12974

			Length	Strain/Species	Flank
genomic	ENSMUSG00000005683	Ensembl Gene Model \| MGI Sequence Detail	24746	C57BL/6J	± kb
transcript	ENSMUST00000005826	Ensembl \| MGI Sequence Detail	2926	Not Applicable
polypeptide	ENSMUSP00000005826	Ensembl \| MGI Sequence Detail	464	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005924 citrate synthase, mitochondrial

(term hierarchy)
PDB

3NZI
EC

2.3.3.1
InterPro Domains

IPR002020 Citrate synthase

IPR019810 Citrate synthase active site

IPR010109 Citrate synthase, eukaryotic-type

IPR016142 Citrate synthase-like, large alpha subdomain

IPR016143 Citrate synthase-like, small alpha subdomain

IPR036969 Citrate synthase superfamily
GlyGen

Q9CZU6 1 site, 1 O-linked glycan (1 site)

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All nucleic 19

cDNA 15

Primer pair 4

Microarray probesets 6

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MGD-MRK-1986, MGD-MRK-2184, MGI:1915151, MGI:1918798, MGI:2143907, MGI:3514039

Summaries

All 69

Developmental Gene Expression 12

Gene Ontology 11

Phenotypes 17
Earliest

J:4573 Cox DR, et al., Comparative gene mapping in man and mouse: assignment of the gene for citrate synthase (Cis) to mouse Chromosome 10. Cytogenet Cell Genet. 1982;32:259 (Abstr.)
Latest

J:346910 Ayyangar U, et al., Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin. EMBO J. 2024 Apr;43(7):1113-1134

TSS for Cs:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96402	Chr10:128173608-128173628 (+)	15 bp
Tssr96403	Chr10:128173630-128173687 (+)	56 bp
Tssr96404	Chr10:128173702-128173713 (+)	105 bp
Tssr96405	Chr10:128197162-128197210 (+)	23,583 bp
Tssr96406	Chr10:128197257-128197275 (+)	23,663 bp
Tssr96407	Chr10:128197983-128198002 (+)	24,390 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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