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Pcyt1a Gene Detail
Summary
  • Symbol
    Pcyt1a
  • Name
    phosphate cytidylyltransferase 1, choline, alpha isoform
  • Synonyms
    Cctalpha, CTalpha, Ctpct, CTP:phosphocholine cytidylyltransferase alpha, Cttalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:88557
    NCBI Gene: 13026
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:32249739-32293883 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 22.69 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    934 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88557
 protein coding gene Chr16:32249739-32293888 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022739
 protein coding gene Chr16:30508592-30557074 (+)
A/J MGP_AJ_G0022704
 protein coding gene Chr16:29062740-29106713 (+)
AKR/J MGP_AKRJ_G0022677
 protein coding gene Chr16:30122403-30167857 (+)
BALB/cJ MGP_BALBcJ_G0022706
 protein coding gene Chr16:29211794-29256002 (+)
C3H/HeJ MGP_C3HHeJ_G0022471
 protein coding gene Chr16:30249463-30295819 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023155
 protein coding gene Chr16:31158116-31206804 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020673
 protein coding gene Chr16:29440009-29482528 (+)
CAST/EiJ MGP_CASTEiJ_G0021999
 protein coding gene Chr16:30376868-30423415 (+)
CBA/J MGP_CBAJ_G0022441
 protein coding gene Chr16:32404670-32451506 (+)
DBA/2J MGP_DBA2J_G0022574
 protein coding gene Chr16:28910212-28954115 (+)
FVB/NJ MGP_FVBNJ_G0022549
 protein coding gene Chr16:28900534-28945128 (+)
LP/J MGP_LPJ_G0022641
 protein coding gene Chr16:30269694-30318631 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022568
 protein coding gene Chr16:31849265-31894011 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023167
 protein coding gene Chr16:30108210-30152533 (+)
PWK/PhJ MGP_PWKPhJ_G0021738
 protein coding gene Chr16:29231444-29277014 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021569
 protein coding gene Chr16:29898242-29949591 (+)
WSB/EiJ MGP_WSBEiJ_G0022043
 protein coding gene Chr16:30054060-30099080 (+)



Homology
more
  • Human Ortholog
    PCYT1A, phosphate cytidylyltransferase 1A, choline
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCYT1A, phosphate cytidylyltransferase 1A, choline
  • Synonyms
    CCTA, CCTalpha, CGL5, CT, CTA, CTPCT, PCYT1, SMDCRD
  • Links
    NCBI Gene ID: 5130
    neXtProt AC: NX_P49585
    UniProt: P49585

  • Chr Location
    3q29; chr3:196214222-196287957 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PCYT1A associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 3 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a targeted null mutation fail to form blastocysts, do not develop past E3.5, and fail to implant.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    955
  • Tissues
    164
  • cDNA Data
    23
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13026 NCBI Gene Model | MGI Sequence Detail 44145 C57BL/6J ±  kb
    transcript NM_001163159 RefSeq | MGI Sequence Detail 4951 ZRU/MplStud  
    polypeptide P49586 UniProt | EBI | MGI Sequence Detail 367 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000012446 choline-phosphate cytidylyltransferase A
      (term hierarchy)
    • EC
      2.7.7.15
    • InterPro Domains
      IPR045049 Choline-phosphate cytidylyltransferase Pcy1-like
      IPR041723 CTP:phosphocholine cytidylyltransferase domain
      IPR004821 Cytidyltransferase-like domain
      IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
    • GlyGen
      P49586 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 8
      cDNA 24
      Primer pair 4

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-2240
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 11
      Gene Ontology 12
      Phenotypes 25
    • Earliest
      J:16168 Rutherford MS, et al., The gene for murine CTP:phosphocholine cytidylyltransferase (Ctpct) is located on mouse chromosome 16. Genomics. 1993 Dec;18(3):698-701
    • Latest
      J:327759 Pollak RM, et al., Metabolic effects of the schizophrenia-associated 3q29 deletion. Transl Psychiatry. 2022 Feb 17;12(1):66
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory