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Cyp1a1 Gene Detail
Summary
  • Symbol
    Cyp1a1
  • Name
    cytochrome P450, family 1, subfamily a, polypeptide 1
  • Synonyms
    cytochrome P450 subfamily I, polypeptide 1, P450-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88588
    NCBI Gene: 13076
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:57595211-57611107 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 31.34 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    357 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88588
 protein coding gene Chr9:57595211-57611107 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034876
 protein coding gene Chr9:56927389-56933695 (+)
A/J MGP_AJ_G0034857
 protein coding gene Chr9:55085403-55092350 (+)
AKR/J MGP_AKRJ_G0034786
 protein coding gene Chr9:56352501-56358717 (+)
BALB/cJ MGP_BALBcJ_G0034849
 protein coding gene Chr9:54870159-54876798 (+)
C3H/HeJ MGP_C3HHeJ_G0034559
 protein coding gene Chr9:56838878-56846135 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035368
 protein coding gene Chr9:58516570-58524555 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032279
 protein coding gene Chr9:54391553-54397863 (+)
CAST/EiJ MGP_CASTEiJ_G0033880
 protein coding gene Chr9:56938466-56944641 (+)
CBA/J MGP_CBAJ_G0034530
 protein coding gene Chr9:60552134-60558343 (+)
DBA/2J MGP_DBA2J_G0034689
 protein coding gene Chr9:54951841-54958073 (+)
FVB/NJ MGP_FVBNJ_G0034631
 protein coding gene Chr9:54182443-54189741 (+)
LP/J MGP_LPJ_G0034772
 protein coding gene Chr9:57225323-57231608 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034674
 protein coding gene Chr9:62047360-62054355 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035390
 protein coding gene Chr9:56373782-56380982 (+)
PWK/PhJ MGP_PWKPhJ_G0033585
 protein coding gene Chr9:54991908-54998053 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033419
 protein coding gene Chr9:56658975-56665124 (+)
WSB/EiJ MGP_WSBEiJ_G0033993
 protein coding gene Chr9:56311971-56318223 (+)



Homology
more
  • Human Ortholog
    CYP1A1, cytochrome P450 family 1 subfamily A member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP1A1, cytochrome P450 family 1 subfamily A member 1
  • Synonyms
    AHH, AHRR, CP11, CYP1, CYPIA1, P1-450, P450-C, P450DX
  • Links
    NCBI Gene ID: 1543
    neXtProt AC: NX_P04798
    UniProt: P04798

  • Chr Location
    15q24.1; chr15:74719542-74725536 (-)  GRCh38
Human Diseases
more
  • Diseases
    39 with human CYP1A1 associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 4 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display resitance to some signs of TCDD induced toxicity but do not display any gross abnormalities in the abscence of treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    96
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    846
  • Tissues
    118
  • cDNA Data
    16
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13076 NCBI Gene Model | MGI Sequence Detail 15897 C57BL/6J ±  kb
    transcript NM_009992 RefSeq | MGI Sequence Detail 2716 ZRU/MplStud  
    polypeptide P00184 UniProt | EBI | MGI Sequence Detail 524 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 7
      cDNA 17
      Primer pair 6
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13109, MGD-MRK-2302
    References
    more
    • Summaries
      All 172
      Developmental Gene Expression 12
      Gene Ontology 18
      Phenotypes 56
    • Earliest
      J:31549 Negishi M, et al., Isolation and characterization of a cloned DNA sequence associated with the murine Ah locus and a 3-methylcholanthrene-induced form of cytochrome P-450. Proc Natl Acad Sci U S A. 1981 Feb;78(2):800-4
    • Latest
      J:351326 Weighardt H, et al., The aryl hydrocarbon receptor (AHR) repressor limits expression of antimicrobial genes but not AHR-dependent genes in intestinal eosinophils. J Leukoc Biol. 2024 May 3;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory