Cyp2a5 MGI Mouse Gene Detail - MGI:88597 - cytochrome P450, family 2, subfamily a, polypeptide 5

Symbol

Cyp2a5
Name

cytochrome P450, family 2, subfamily a, polypeptide 5
Synonyms

Coh

Feature Type

protein coding gene
IDs

MGI:88597
NCBI Gene: 13087
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr7:26534764-26542689 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 15.54 cM
Mapping Data

19 experiments

SNPs within 2kb

235 from dbSNP Build 142
Strain Annotations

9
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88597	protein coding gene	Chr7:26534730-26542973 (+)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	MGP_C3HHeJ_G0031590	protein coding gene	Chr7:25258099-25856898 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032339	protein coding gene	Chr7:26283300-26309322 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029394	protein coding gene	Chr7:26094394-26102545 (+)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0031555	protein coding gene	Chr7:26658960-27511019 (+)
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	MGP_LPJ_G0031795	protein coding gene	Chr7:25692811-25708553 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031705	protein coding gene	Chr7:26952803-26988126 (+)
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0030490	protein coding gene	Chr7:16137453-16145557 (+)
WSB/EiJ	MGP_WSBEiJ_G0031040	protein coding gene	Chr7:25291587-25319792 (+)

Human Ortholog

CYP2A13, cytochrome P450 family 2 subfamily A member 13

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CYP2A13, cytochrome P450 family 2 subfamily A member 13
Synonyms

CPAD, CYP2A, CYPIIA13
Links

HGNC:2608

NCBI Gene ID: 1553

neXtProt AC: NX_Q16696

UniProt: Q16696
Chr Location

19q13.2; chr19:41088451-41096195 (+) GRCh38

Human Ortholog

CYP2A6, cytochrome P450 family 2 subfamily A member 6
Synonyms

CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB
Links

HGNC:2610

NCBI Gene ID: 1548

neXtProt AC: NX_P11509

UniProt: P11509
Chr Location

19q13.2; chr19:40843541-40850447 (-) GRCh38

Human Ortholog

CYP2A7, cytochrome P450 family 2 subfamily A member 7
Synonyms

CPA7, CPAD, CYP2A, CYPIIA7, P450-IIA4
Links

HGNC:2611

NCBI Gene ID: 1549

neXtProt AC: NX_P20853

UniProt: P20853
Chr Location

19q13.2; chr19:40875439-40882752 (-) GRCh38

MGI Vertebrate Homology

Cyp2a5 stringent orthology
3 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CYP2A13, CYP2A6, CYP2A7
Gene Tree

Cyp2a5

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Targeted

4
Genomic Mutations

2 involving Cyp2a5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available

Mice exhibit strain-specific cytochrome activity levels. Mice homozygous for a knock-out allele exhibit slower clearance of nicotine and cotinine.

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All GO Annotations

21
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

847
Tissues

99
cDNA Data

14
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS21008.1

Ensembl

ENSMUSG00000005547 (Evidence)
NCBI Gene

13087

			Length	Strain/Species	Flank
genomic	13087	NCBI Gene Model \| MGI Sequence Detail	7926	C57BL/6J	± kb
transcript	NM_007812	RefSeq \| MGI Sequence Detail	1746	ZRU/MplStud
polypeptide	P20852	UniProt \| EBI \| MGI Sequence Detail	494	Not Applicable

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UniProt

1 Sequence
GlyGen

P20852 1 site, 1 O-linked glycan (1 site)

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All nucleic 22

Genomic 4

cDNA 16

Primer pair 2

Microarray probesets 1

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MGD-MRK-2050, MGD-MRK-2299, MGD-MRK-2314

Summaries

All 78

Developmental Gene Expression 8

Gene Ontology 8

Phenotypes 17
Earliest

J:5987 Lush IE, et al., Genetic variation between mice in their metabolism of coumarin and its derivatives. Genet Res. 1978 Apr;31(2):177-86
Latest

J:342868 Oguro A, et al., Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder. J Lipid Res. 2023 Nov;64(11):100458

TSS for Cyp2a5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65198	Chr7:26534762-26534768 (+)	1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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