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Cyp2e1 Gene Detail
Summary
  • Symbol
    Cyp2e1
  • Name
    cytochrome P450, family 2, subfamily e, polypeptide 1
  • Synonyms
    Cyp2e
  • Feature Type
    protein coding gene
  • IDs
    MGI:88607
    NCBI Gene: 13106
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:140343732-140354903 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 85.94 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    388 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88607
 protein coding gene Chr7:140343652-140354903 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033189
 protein coding gene Chr7:145889982-145903301 (+)
A/J MGP_AJ_G0033171
 protein coding gene Chr7:141746155-141757391 (+)
AKR/J MGP_AKRJ_G0033103
 protein coding gene Chr7:145631434-145645810 (+)
BALB/cJ MGP_BALBcJ_G0033172
 protein coding gene Chr7:141472707-141483943 (+)
C3H/HeJ MGP_C3HHeJ_G0032886
 protein coding gene Chr7:145387484-145398720 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033683
 protein coding gene Chr7:151229970-151241206 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030656
 protein coding gene Chr7:142960606-142971934 (+)
CAST/EiJ MGP_CASTEiJ_G0032216
 protein coding gene Chr7:137686611-137697986 (+)
CBA/J MGP_CBAJ_G0032858
 protein coding gene Chr7:156354931-156366159 (+)
DBA/2J MGP_DBA2J_G0033011
 protein coding gene Chr7:139684564-139695800 (+)
FVB/NJ MGP_FVBNJ_G0032963
 protein coding gene Chr7:139595186-139606594 (+)
LP/J MGP_LPJ_G0033105
 protein coding gene Chr7:147390038-147401274 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032996
 protein coding gene Chr7:157029836-157041060 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033703
 protein coding gene Chr7:144617123-144628359 (+)
PWK/PhJ MGP_PWKPhJ_G0031921
 protein coding gene Chr7:132942606-132954005 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031767
 protein coding gene Chr7:131428266-131439494 (+)
WSB/EiJ MGP_WSBEiJ_G0032327
 protein coding gene Chr7:145529672-145540911 (+)



Homology
more
  • Human Ortholog
    CYP2E1, cytochrome P450 family 2 subfamily E member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP2E1, cytochrome P450 family 2 subfamily E member 1
  • Synonyms
    CPE1, CYP2E, P450C2E, P450-J
  • Links
    NCBI Gene ID: 1571
    neXtProt AC: NX_P05181
    UniProt: P05181

  • Chr Location
    10q26.3; chr10:133520406-133561220 (+)  GRCh38
Human Diseases
more
  • Diseases
    13 with human CYP2E1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit altered responses to xenobiotics including decreased urethane-induced tumors and allylnitrile- or acetamenophen-associated mortality but increased allylnitrile-induced vestibular function loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    833
  • Tissues
    115
  • cDNA Data
    811
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13106 NCBI Gene Model | MGI Sequence Detail 11172 C57BL/6J ±  kb
    transcript NM_021282 RefSeq | MGI Sequence Detail 1762 ZRU/MplStud  
    polypeptide Q05421 UniProt | EBI | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 815
      Genomic 2
      cDNA 812
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2326, MGD-MRK-2327
    References
    more
    • Summaries
      All 149
      Developmental Gene Expression 10
      Gene Ontology 10
      Phenotypes 68
    • Earliest
      J:15752 Kalb VF, et al., A cluster of repetitive elements within a 700 base pair region in the mouse genome. Nucleic Acids Res. 1983 Apr 11;11(7):2177-84
    • Latest
      J:348105 Chen H, et al., Pre-eclamptic foetal programming predisposes offspring to hepatic steatosis via DNA methylation. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 20;1870(5):167189
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory