Slc22a6 MGI Mouse Gene Detail - MGI:892001 - solute carrier family 22 (organic anion transporter), member 6

Symbol

Slc22a6
Name

solute carrier family 22 (organic anion transporter), member 6
Synonyms

mOat1, NKT, Oat1, Orctl1

Feature Type

protein coding gene
IDs

MGI:892001
NCBI Gene: 18399
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr19:8595403-8605663 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 5.44 cM
Mapping Data

6 experiments

SNPs within 2kb

266 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_892001	protein coding gene	Chr19:8595360-8605663 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024801	protein coding gene	Chr19:5883223-5893523 (+)
A/J	MGP_AJ_G0024769	protein coding gene	Chr19:5570097-5580397 (+)
AKR/J	MGP_AKRJ_G0024744	protein coding gene	Chr19:5651939-5662248 (+)
BALB/cJ	MGP_BALBcJ_G0024769	protein coding gene	Chr19:5669847-5680145 (+)
C3H/HeJ	MGP_C3HHeJ_G0024535	protein coding gene	Chr19:5738519-5748817 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025216	protein coding gene	Chr19:5994676-6005012 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022645	protein coding gene	Chr19:5807821-5818122 (+)
CAST/EiJ	MGP_CASTEiJ_G0024008	protein coding gene	Chr19:5384421-5394744 (+)
CBA/J	MGP_CBAJ_G0024509	protein coding gene	Chr19:6109245-6119530 (+)
DBA/2J	MGP_DBA2J_G0024636	protein coding gene	Chr19:5394288-5404619 (+)
FVB/NJ	MGP_FVBNJ_G0024603	protein coding gene	Chr19:5474383-5484678 (+)
LP/J	MGP_LPJ_G0024723	protein coding gene	Chr19:5768196-5783433 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024630	protein coding gene	Chr19:5977676-5987984 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025265	protein coding gene	Chr19:5693095-5703394 (+)
PWK/PhJ	MGP_PWKPhJ_G0023753	protein coding gene	Chr19:5061790-5072212 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023558	protein coding gene	Chr19:5301721-5311938 (+)
WSB/EiJ	MGP_WSBEiJ_G0024070	protein coding gene	Chr19:5662491-5672788 (+)

Human Ortholog

SLC22A6, solute carrier family 22 member 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC22A6, solute carrier family 22 member 6
Synonyms

HOAT1, OAT1, PAHT, ROAT1
Links

HGNC:10970

NCBI Gene ID: 9356

neXtProt AC: NX_Q4U2R8

UniProt: Q4U2R8
Chr Location

11q12.3; chr11:62936385-62984967 (-) GRCh38

MGI Vertebrate Homology

Slc22a6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC22A6
Gene Tree

Slc22a6

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Phenotype Summary

4 phenotypes from 1 allele in 3 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene may result in increased thymus weight or impaired renal organic anion excretion for a subset of organic anions.

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All GO Annotations

61
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1141
Tissues

220
cDNA Data

91
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc22a6

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All Sequences

29
RefSeq

2
UniProt

1
CCDS

CCDS29538.1

Ensembl

ENSMUSG00000024650 (Evidence)
NCBI Gene

18399

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024650	Ensembl Gene Model \| MGI Sequence Detail	10261	C57BL/6J	± kb
transcript	ENSMUST00000010250	Ensembl \| MGI Sequence Detail	3983	Not Applicable
polypeptide	ENSMUSP00000010250	Ensembl \| MGI Sequence Detail	545	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014993 solute carrier family 22 member 6

(term hierarchy)
InterPro Domains

IPR005828 Major facilitator, sugar transporter-like

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

IPR004749 Organic cation transport protein/SVOP
GlyGen

Q8VC69 6 sites

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All nucleic 99

cDNA 92

Primer pair 6

Other 1

Microarray probesets 4

Summaries

All 72

Developmental Gene Expression 13

Gene Ontology 14

Phenotypes 20
Earliest

J:38984 Lopez-Nieto CE, et al., Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. J Biol Chem. 1997 Mar 7;272(10):6471-8
Latest

J:352436 Granados JC, et al., The kidney drug transporter OAT1 regulates gut microbiome-dependent host metabolism. JCI Insight. 2023 Jan 24;8(2)

TSS for Slc22a6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154783	Chr19:8595355-8595364 (+)	-43 bp
Tssr154784	Chr19:8595369-8595408 (+)	-14 bp
Tssr154785	Chr19:8595410-8595420 (+)	12 bp
Tssr154786	Chr19:8595497-8595517 (+)	104 bp
Tssr154787	Chr19:8595524-8595548 (+)	133 bp
Tssr154788	Chr19:8595553-8595564 (+)	156 bp
Tssr154789	Chr19:8595689-8595701 (+)	292 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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