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Gsc2 Gene Detail
Summary
  • Symbol
    Gsc2
  • Name
    goosecoid homebox 2
  • Synonyms
    4930568H22Rik, Gscl
  • Feature Type
    protein coding gene
  • IDs
    MGI:892006
    NCBI Gene: 195333
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr16:17730978-17732891 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.10 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_892006
 protein coding gene Chr16:17730971-17732923 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022598
 protein coding gene Chr16:15102348-15104300 (-)
A/J MGP_AJ_G0022559
 protein coding gene Chr16:14349169-14351121 (-)
AKR/J MGP_AKRJ_G0022536
 protein coding gene Chr16:14908440-14910392 (-)
BALB/cJ MGP_BALBcJ_G0022562
 protein coding gene Chr16:14504000-14505952 (-)
C3H/HeJ MGP_C3HHeJ_G0022329
 protein coding gene Chr16:15056405-15058357 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023013
 protein coding gene Chr16:15343642-15345594 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020533
 protein coding gene Chr16:14407200-14409188 (-)
CAST/EiJ MGP_CASTEiJ_G0021857
 protein coding gene Chr16:14974150-14976117 (-)
CBA/J MGP_CBAJ_G0022300
 protein coding gene Chr16:16015591-16017543 (-)
DBA/2J MGP_DBA2J_G0022430
 protein coding gene Chr16:14261059-14263011 (-)
FVB/NJ MGP_FVBNJ_G0022406
 protein coding gene Chr16:14312950-14314902 (-)
LP/J MGP_LPJ_G0022497
 protein coding gene Chr16:14884072-14886024 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022427
 protein coding gene Chr16:15694484-15696436 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023024
 protein coding gene Chr16:14854395-14856347 (-)
PWK/PhJ MGP_PWKPhJ_G0021600
 protein coding gene Chr16:14520650-14522606 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021428
 protein coding gene Chr16:14824326-14826287 (-)
WSB/EiJ MGP_WSBEiJ_G0021904
 protein coding gene Chr16:14838189-14840143 (-)



Homology
more
  • Human Ortholog
    GSC2, goosecoid homeobox 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSC2, goosecoid homeobox 2
  • Synonyms
    GSCL
  • Links
    NCBI Gene ID: 2928
    neXtProt AC: NX_O15499
    UniProt: O15499

  • Chr Location
    22q11.21; chr22:19146993-19150292 (-)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    138 phenotype references
Mice homozygous for either one of two independently generated knock-out alleles are viable and fertile with no detectable anatomical or histological abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    931
  • Tissues
    138
  • cDNA Data
    14
  • Literature Summary
    16
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 195333 NCBI Gene Model | MGI Sequence Detail 1914 C57BL/6J ±  kb
transcript NM_029469 RefSeq | MGI Sequence Detail 1133 Not Specified  
polypeptide P56916 UniProt | EBI | MGI Sequence Detail 201 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 53
    Genomic 27
    cDNA 14
    Primer pair 10
    Other 2

    Microarray probesets 2
Other
Accession IDs
less
MGI:1923125
References
more
  • Summaries
    All 181
    Developmental Gene Expression 16
    Diseases 6
    Gene Ontology 7
    Phenotypes 138
  • Earliest
    J:32846 Halford S, et al., Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and familial congenital heart disease. Hum Mol Genet. 1993 Dec;2(12):2099-107
  • Latest
    J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory