Pld2 MGI Mouse Gene Detail - MGI:892877

Symbol

Pld2
Name

phospholipase D2

Feature Type

protein coding gene
IDs

MGI:892877
NCBI Gene: 18806
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:70430890-70448936 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.99 cM
Mapping Data

2 experiments

SNPs within 2kb

124 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_892877	protein coding gene	Chr11:70430318-70448936 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018602	protein coding gene	Chr11:71078275-71097349 (+)
A/J	MGP_AJ_G0018570	protein coding gene	Chr11:68380821-68400492 (+)
AKR/J	MGP_AKRJ_G0018539	protein coding gene	Chr11:70437217-70458910 (+)
BALB/cJ	MGP_BALBcJ_G0018542	protein coding gene	Chr11:68701418-68720523 (+)
C3H/HeJ	MGP_C3HHeJ_G0018355	protein coding gene	Chr11:70463938-70482358 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018993	protein coding gene	Chr11:73230124-73250240 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016638	protein coding gene	Chr11:65302473-65320506 (+)
CAST/EiJ	MGP_CASTEiJ_G0017910	protein coding gene	Chr11:70719228-70740301 (+)
CBA/J	MGP_CBAJ_G0018327	protein coding gene	Chr11:76515553-76536113 (+)
DBA/2J	MGP_DBA2J_G0018437	protein coding gene	Chr11:67963434-67981775 (+)
FVB/NJ	MGP_FVBNJ_G0018427	protein coding gene	Chr11:67609492-67627687 (+)
LP/J	MGP_LPJ_G0018507	protein coding gene	Chr11:71653392-71672894 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018450	protein coding gene	Chr11:77087504-77108210 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019035	protein coding gene	Chr11:70695549-70714126 (+)
PWK/PhJ	MGP_PWKPhJ_G0017684	protein coding gene	Chr11:68604787-68623914 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017474	protein coding gene	Chr11:70512648-70531965 (+)
WSB/EiJ	MGP_WSBEiJ_G0017964	protein coding gene	Chr11:70359131-70378702 (+)

Human Ortholog

PLD2, phospholipase D2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLD2, phospholipase D2
Synonyms

PLD1C
Links

HGNC:9068

NCBI Gene ID: 5338

neXtProt AC: NX_O14939

UniProt: O14939
Chr Location

17p13.2; chr17:4807152-4823434 (+) GRCh38

MGI Vertebrate Homology

Pld2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PLD2
Protein SuperFamily

Phospholipase_D_euk
Gene Tree

Pld2

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Phenotype Summary

5 phenotypes from 4 alleles in 5 genetic backgrounds
11 phenotypes from multigenic genotypes
49 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (other)

1
Endonuclease-mediated

6
Targeted

13
Genomic Mutations

2 involving Pld2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

49 strains or lines available

Mice homozygous for a knock-out fail to exhibit Abeta42 suppression of LTP and show altered brain phosphatidic acid levels. Mice homozygous for a different knock-out allele show normal platelet function, hemostasis and thrombus formation.

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All GO Annotations

30
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

970
Tissues

114
cDNA Data

43
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pld2

ZFIN pld2

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All Sequences

70
RefSeq

20
UniProt

7
CCDS

CCDS24953.1, CCDS78979.1, CCDS78980.1

Ensembl

ENSMUSG00000020828 (Evidence)
NCBI Gene

18806

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020828	Ensembl Gene Model \| MGI Sequence Detail	18047	C57BL/6J	± kb
transcript	ENSMUST00000108557	Ensembl \| MGI Sequence Detail	3655	Not Applicable
polypeptide	ENSMUSP00000104197	Ensembl \| MGI Sequence Detail	944	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000012844 phospholipase D2

(term hierarchy)
EC

3.1.4.4
InterPro Domains

IPR011993 PH-like domain superfamily

IPR016555 Phospholipase D, eukaryotic type

IPR015679 Phospholipase D family

IPR025202 Phospholipase D-like domain

IPR001736 Phospholipase D/Transphosphatidylase

IPR001683 Phox homology

IPR001849 Pleckstrin homology domain

IPR036871 PX domain superfamily

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All nucleic 45

Genomic 1

cDNA 43

Primer pair 1

Microarray probesets 5

Summaries

All 91

Developmental Gene Expression 5

Gene Ontology 7

Phenotypes 49
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:354040 Su Z, et al., Importance of PLD2 in an IL-23 driven psoriasiform dermatitis model and potential link to human psoriasis. J Dermatol. 2023 Oct;50(10):1321-1329

TSS for Pld2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102733	Chr11:70430871-70430895 (+)	-7 bp
Tssr102734	Chr11:70430997-70431020 (+)	119 bp
Tssr102735	Chr11:70431086-70431141 (+)	224 bp
Tssr102736	Chr11:70431316-70431334 (+)	435 bp
Tssr102737	Chr11:70431335-70431372 (+)	464 bp
Tssr102738	Chr11:70431655-70431666 (+)	771 bp
Tssr102739	Chr11:70431679-70431714 (+)	807 bp
Tssr102740	Chr11:70431717-70431733 (+)	835 bp
Tssr102741	Chr11:70431737-70431744 (+)	851 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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