Prap1 MGI Mouse Gene Detail - MGI:893573 - proline-rich acidic protein 1

Symbol

Prap1
Name

proline-rich acidic protein 1
Synonyms

Upa

Feature Type

protein coding gene
IDs

MGI:893573
NCBI Gene: 22264
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr7:139673308-139677113 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 85.10 cM, cytoband F5
Mapping Data

1 experiment

SNPs within 2kb

252 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_893573	protein coding gene	Chr7:139673308-139677116 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033162	protein coding gene	Chr7:145175087-145185090 (+)
A/J	MGP_AJ_G0033144	protein coding gene	Chr7:141042792-141046593 (+)
AKR/J	MGP_AKRJ_G0033076	protein coding gene	Chr7:144883821-144888315 (+)
BALB/cJ	MGP_BALBcJ_G0033145	protein coding gene	Chr7:140772625-140779484 (+)
C3H/HeJ	MGP_C3HHeJ_G0032859	protein coding gene	Chr7:144688683-144692328 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033656	protein coding gene	Chr7:150513592-150517360 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030629	protein coding gene	Chr7:142164423-142168106 (+)
CAST/EiJ	MGP_CASTEiJ_G0032189	protein coding gene	Chr7:136988129-136993040 (+)
CBA/J	MGP_CBAJ_G0032832	protein coding gene	Chr7:155578873-155585118 (+)
DBA/2J	MGP_DBA2J_G0032984	protein coding gene	Chr7:139005263-139009256 (+)
FVB/NJ	MGP_FVBNJ_G0032937	protein coding gene	Chr7:138899720-138903487 (+)
LP/J	MGP_LPJ_G0033078	protein coding gene	Chr7:146713189-146716927 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032969	protein coding gene	Chr7:156241421-156253710 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033676	protein coding gene	Chr7:143888328-143892947 (+)
PWK/PhJ	MGP_PWKPhJ_G0031895	protein coding gene	Chr7:132187256-132191074 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031740	protein coding gene	Chr7:130721887-130725632 (+)
WSB/EiJ	MGP_WSBEiJ_G0032300	protein coding gene	Chr7:144778314-144783406 (+)

Human Ortholog

PRAP1, proline rich acidic protein 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRAP1, proline rich acidic protein 1
Synonyms

PRO1195, UPA
Links

HGNC:23304

NCBI Gene ID: 118471

neXtProt AC: NX_Q96NZ9

UniProt: Q96NZ9
Chr Location

10q26.3; chr10:133347368-133352683 (+) GRCh38

MGI Vertebrate Homology

Prap1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PRAP1
Gene Tree

Prap1

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Phenotype Summary

14 phenotypes from 1 allele in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

5
Radiation induced

1
Targeted

6
Genomic Mutations

1 involving Prap1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit an increased serum IgG2a response to ovalbumin challenge, increased serum immunoglobulin and cytokine levels, altered microbiota in the small intestine, and increased mortality and enterocyte apoptosis in response to ionizing radiation.

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All GO Annotations

17
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

758
Tissues

50
cDNA Data

42
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

28
RefSeq

2
UniProt

1
CCDS

CCDS21963.1

Ensembl

ENSMUSG00000025467 (Evidence)
NCBI Gene

22264

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025467	Ensembl Gene Model \| MGI Sequence Detail	3806	C57BL/6J	± kb
transcript	ENSMUST00000026540	Ensembl \| MGI Sequence Detail	620	Not Applicable
polypeptide	ENSMUSP00000026540	Ensembl \| MGI Sequence Detail	149	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013171 proline-rich acidic protein 1

(term hierarchy)
InterPro Domains

IPR027922 Proline-rich acidic protein 1

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All nucleic 45

cDNA 42

Primer pair 3

Microarray probesets 3

Summaries

All 40

Developmental Gene Expression 7

Gene Ontology 4

Phenotypes 12
Earliest

J:53304 Schorpp-Kistner M, et al., JunB is essential for mammalian placentation. EMBO J. 1999 Feb 15;18(4):934-48
Latest

J:343810 Guo CG, et al., Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion. Mol Metab. 2023 Nov 30;79:101847

TSS for Prap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr2443	Chr7:139673175-139673187 (+)	-127 bp
Tssr69780	Chr7:139673301-139673315 (+)	0 bp
Tssr69781	Chr7:139673317-139673328 (+)	15 bp
Tssr69782	Chr7:139674940-139674954 (+)	1,639 bp
Tssr69783	Chr7:139676633-139676644 (+)	3,331 bp
Tssr2444	Chr7:139676645-139676650 (+)	3,340 bp
Tssr69784	Chr7:139676877-139676891 (+)	3,576 bp
Tssr69785	Chr7:139676966-139676993 (+)	3,672 bp
Tssr69786	Chr7:139677004-139677032 (+)	3,710 bp
Tssr69787	Chr7:139677034-139677065 (+)	3,742 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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