Plscr1 MGI Mouse Gene Detail - MGI:893575 - phospholipid scramblase 1

Symbol

Plscr1
Name

phospholipid scramblase 1
Synonyms

MmTRA1a, MmTRA1b, MuPLSCR2, NOR1, TRA1, Tras1, Tras2

Feature Type

protein coding gene
IDs

MGI:893575
NCBI Gene: 22038
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr9:92132265-92154034 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 48.35 cM, cytoband E3.3
Mapping Data

2 experiments

SNPs within 2kb

892 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_893575	protein coding gene	Chr9:92131803-92154331 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035126	protein coding gene	Chr9:93299452-93321551 (+)
A/J	MGP_AJ_G0035107	protein coding gene	Chr9:90070627-90093867 (+)
AKR/J	MGP_AKRJ_G0035039	protein coding gene	Chr9:92174299-92187875 (+)
BALB/cJ	MGP_BALBcJ_G0035100	protein coding gene	Chr9:89719801-89742485 (+)
C3H/HeJ	MGP_C3HHeJ_G0034810	protein coding gene	Chr9:92639545-92660421 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035620	protein coding gene	Chr9:95904479-95930743 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032523	protein coding gene	Chr9:88079600-88102599 (+)
CAST/EiJ	MGP_CASTEiJ_G0034122	protein coding gene	Chr9:92375318-92399615 (+)
CBA/J	MGP_CBAJ_G0034778	protein coding gene	Chr9:99246347-99261850 (+)
DBA/2J	MGP_DBA2J_G0034940	protein coding gene	Chr9:89588556-89611105 (+)
FVB/NJ	MGP_FVBNJ_G0034888	protein coding gene	Chr9:88553030-88575568 (+)
LP/J	MGP_LPJ_G0035019	protein coding gene	Chr9:93489606-93518030 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034927	protein coding gene	Chr9:101164854-101201256 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035640	protein coding gene	Chr9:92449168-92471481 (+)
PWK/PhJ	MGP_PWKPhJ_G0033829	protein coding gene	Chr9:89744214-89767880 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033664	protein coding gene	Chr9:92494603-92515982 (+)
WSB/EiJ	MGP_WSBEiJ_G0034242	protein coding gene	Chr9:92324849-92347591 (+)

Human Ortholog

PLSCR1, phospholipid scramblase 1

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLSCR1, phospholipid scramblase 1
Synonyms

MMTRA1B
Links

HGNC:9092

NCBI Gene ID: 5359

neXtProt AC: NX_O15162

UniProt: O15162
Chr Location

3q24; chr3:146515180-146544856 (-) GRCh38

MGI Vertebrate Homology

Plscr1 stringent orthology
1 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: PLSCR1
Gene Tree

Plscr1

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

5
Targeted

5
Genomic Mutations

1 involving Plscr1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display a grossly normal phenotype although there are hematopoietic abnormalities in newborn mice.

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All GO Annotations

92
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

734
Tissues

4
cDNA Data

10
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PLSCR1

Xenbase plscr1

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All Sequences

45
RefSeq

4
UniProt

4
CCDS

CCDS52886.1

Ensembl

ENSMUSG00000032369 (Evidence)
NCBI Gene

22038

			Length	Strain/Species	Flank
genomic	22038	NCBI Gene Model \| MGI Sequence Detail	21770	C57BL/6J	± kb
transcript	NM_001410453	RefSeq \| MGI Sequence Detail	1607	C57BL/6
polypeptide	Q9JJ00	UniProt \| EBI \| MGI Sequence Detail	328	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000012884 phospholipid scramblase 1

(term hierarchy)
EC

3.1.-.-
InterPro Domains

IPR005552 Scramblase
GlyGen

Q9JJ00 1 site, 1 O-linked glycan (1 site)

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All nucleic 13

cDNA 13

Microarray probesets 5

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MGI:893574

Summaries

All 63

Developmental Gene Expression 1

Gene Ontology 12

Phenotypes 25
Earliest

J:39827 Kasukabe T, et al., TRA1, a novel mRNA highly expressed in leukemogenic mouse monocytic sublines but not in nonleukemogenic sublines. Blood. 1997 Apr 15;89(8):2975-85
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Plscr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86494	Chr9:92131709-92131720 (+)	-550 bp
Tssr86495	Chr9:92131731-92131742 (+)	-528 bp
Tssr86496	Chr9:92131768-92131782 (+)	-490 bp
Tssr86497	Chr9:92131802-92131806 (+)	-461 bp
Tssr86498	Chr9:92132079-92132087 (+)	-182 bp
Tssr86499	Chr9:92132092-92132113 (+)	-162 bp
Tssr86500	Chr9:92132114-92132121 (+)	-147 bp
Tssr86501	Chr9:92132136-92132151 (+)	-121 bp
Tssr86502	Chr9:92132177-92132180 (+)	-86 bp
Tssr86503	Chr9:92132218-92132240 (+)	-36 bp
Tssr86504	Chr9:92132248-92132327 (+)	23 bp
Tssr86505	Chr9:92132349-92132364 (+)	92 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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