Stx4a MGI Mouse Gene Detail - MGI:893577

Symbol

Stx4a
Name

syntaxin 4A (placental)
Synonyms

Stx4, Syn-4, Syn4

Feature Type

protein coding gene
IDs

MGI:893577
NCBI Gene: 20909
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr7:127439832-127450160 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 69.77 cM, cytoband F4
Mapping Data

2 experiments

SNPs within 2kb

314 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_893577	protein coding gene	Chr7:127423466-127450160 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033057	protein coding gene	Chr7:132199010-132228291 (+)
A/J	MGP_AJ_G0033040	protein coding gene	Chr7:128665082-128693592 (+)
AKR/J	MGP_AKRJ_G0032972	protein coding gene	Chr7:131992330-132020475 (+)
BALB/cJ	MGP_BALBcJ_G0033041	protein coding gene	Chr7:128317960-128343671 (+)
C3H/HeJ	MGP_C3HHeJ_G0032755	protein coding gene	Chr7:131892589-131921867 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033550	protein coding gene	Chr7:137349312-137379791 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030523	protein coding gene	Chr7:129863718-129885937 (+)
CAST/EiJ	MGP_CASTEiJ_G0032084	protein coding gene	Chr7:123690100-123713652 (+)
CBA/J	MGP_CBAJ_G0032728	protein coding gene	Chr7:142005875-142040608 (+)
DBA/2J	MGP_DBA2J_G0032880	protein coding gene	Chr7:126645679-126669389 (+)
FVB/NJ	MGP_FVBNJ_G0032833	protein coding gene	Chr7:126504244-126530587 (+)
LP/J	MGP_LPJ_G0032974	protein coding gene	Chr7:133672541-133702514 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032865	protein coding gene	Chr7:143085290-143112783 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033570	protein coding gene	Chr7:130984963-131009925 (+)
PWK/PhJ	MGP_PWKPhJ_G0031791	protein coding gene	Chr7:119658168-119682313 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031637	protein coding gene	Chr7:117787162-117812736 (+)
WSB/EiJ	MGP_WSBEiJ_G0032196	protein coding gene	Chr7:131952171-131978124 (+)

Human Ortholog

STX4, syntaxin 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STX4, syntaxin 4
Synonyms

DFNB123, p35-2, STX4A
Links

HGNC:11439

NCBI Gene ID: 6810

neXtProt AC: NX_Q12846

UniProt: Q12846
Chr Location

16p11.2; chr16:31032889-31042975 (+) GRCh38

MGI Vertebrate Homology

Stx4a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: STX4
Gene Tree

Stx4a

Diseases

1 with human STX4 associations

				Human Disease	Mouse Models
				autosomal recessive nonsyndromic deafness IDs autosomal recessive nonsyndromic deafness DOID:0050565 ICD10CM:H90.3 OMIM:607197 OMIM:PS220290 ORDO:90636

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 5 alleles in 6 genetic backgrounds
1 phenotype from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Gene trapped

1
Targeted

9
Incidental Mutations

APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted null allele die in early embyonic stages. Heterozygous mice exhibit abnormalities in glucose metabolism.

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All GO Annotations

119
GO References

27

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

33
cDNA Data

52
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

60
RefSeq

18
UniProt

2
CCDS

CCDS21880.1

Ensembl

ENSMUSG00000030805 (Evidence)
NCBI Gene

20909

			Length	Strain/Species	Flank
genomic	20909	NCBI Gene Model \| MGI Sequence Detail	10329	C57BL/6J	± kb
transcript	NM_001417272	RefSeq \| MGI Sequence Detail	1478	C57BL/6
polypeptide	P70452	UniProt \| EBI \| MGI Sequence Detail	298	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015796 syntaxin-4

(term hierarchy)
PDB

3PUJ, 3PUK, 8BBJ
InterPro Domains

IPR010989 SNARE

IPR045242 Syntaxin

IPR006012 Syntaxin/epimorphin, conserved site

IPR006011 Syntaxin, N-terminal domain

IPR000727 Target SNARE coiled-coil homology domain

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All nucleic 54

cDNA 54

Microarray probesets 3

Summaries

All 79

Developmental Gene Expression 5

Gene Ontology 27

Phenotypes 15
Earliest

J:23761 Katagiri H, et al., A novel isoform of syntaxin-binding protein homologous to yeast Sec1 expressed ubiquitously in mammalian cells. J Biol Chem. 1995 Mar 10;270(10):4963-6
Latest

J:348947 Yu X, et al., Involution of brown adipose tissue through a Syntaxin 4 dependent pyroptosis pathway. Nat Commun. 2024 Apr 2;15(1):2856

TSS for Stx4a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69296	Chr7:127440169-127440190 (+)	348 bp
Tssr69297	Chr7:127440872-127440915 (+)	1,062 bp
Tssr69298	Chr7:127440924-127440975 (+)	1,118 bp
Tssr69299	Chr7:127440989-127441019 (+)	1,172 bp
Tssr69300	Chr7:127441029-127441037 (+)	1,201 bp
Tssr69301	Chr7:127441038-127441052 (+)	1,213 bp
Tssr69302	Chr7:127441076-127441105 (+)	1,259 bp
Tssr69303	Chr7:127441119-127441134 (+)	1,295 bp
Tssr69304	Chr7:127447559-127447570 (+)	7,733 bp
Tssr69305	Chr7:127448050-127448089 (+)	8,238 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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