About   Help   FAQ
Mknk2 Gene Detail
Summary
  • Symbol
    Mknk2
  • Name
    MAP kinase-interacting serine/threonine kinase 2
  • Synonyms
    2010016G11Rik, Mnk2
  • Feature Type
    protein coding gene
  • IDs
    MGI:894279
    NCBI Gene: 17347
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80501152-80512264 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    202 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894279
 protein coding gene Chr10:80501152-80513946 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017513
 protein coding gene Chr10:81304361-81317156 (-)
A/J MGP_AJ_G0017491
 protein coding gene Chr10:78455398-78468190 (-)
AKR/J MGP_AKRJ_G0017452
 protein coding gene Chr10:80609610-80622402 (-)
BALB/cJ MGP_BALBcJ_G0017453
 protein coding gene Chr10:78669865-78682665 (-)
C3H/HeJ MGP_C3HHeJ_G0017276
 protein coding gene Chr10:80689199-80701986 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017907
 protein coding gene Chr10:84109673-84125332 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015596
 protein coding gene Chr10:74661794-74674534 (-)
CAST/EiJ MGP_CASTEiJ_G0016843
 protein coding gene Chr10:80908802-80921603 (-)
CBA/J MGP_CBAJ_G0017248
 protein coding gene Chr10:87379491-87392281 (-)
DBA/2J MGP_DBA2J_G0017354
 protein coding gene Chr10:77653475-77666277 (-)
FVB/NJ MGP_FVBNJ_G0017348
 protein coding gene Chr10:76870033-76883299 (-)
LP/J MGP_LPJ_G0017425
 protein coding gene Chr10:81773654-81786434 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017374
 protein coding gene Chr10:89298541-89312278 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017948
 protein coding gene Chr10:80593614-80606403 (-)
PWK/PhJ MGP_PWKPhJ_G0016624
 protein coding gene Chr10:77538778-77551586 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016414
 protein coding gene Chr10:79549004-79561778 (-)
WSB/EiJ MGP_WSBEiJ_G0016903
 protein coding gene Chr10:80633457-80646227 (-)



Homology
more
  • Human Ortholog
    MKNK2, MAPK interacting serine/threonine kinase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MKNK2, MAPK interacting serine/threonine kinase 2
  • Synonyms
    GPRK7, MNK2
  • Links
    NCBI Gene ID: 2872
    neXtProt AC: NX_Q9HBH9
    UniProt: Q9HBH9

  • Chr Location
    19p13.3; chr19:2037465-2051244 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    26 phenotype references
Homozygous null mice are viable and fertile with no gross abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    36
  • cDNA Data
    10
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 17347 NCBI Gene Model | MGI Sequence Detail 11113 C57BL/6J ±  kb
transcript NM_001428630 RefSeq | MGI Sequence Detail 3500 C57BL/6  
polypeptide Q8CDB0 UniProt | EBI | MGI Sequence Detail 459 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 12
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1916453
References
more
  • Summaries
    All 65
    Developmental Gene Expression 3
    Gene Ontology 11
    Phenotypes 26
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:332857 Liu D, et al., Circadian activities of the brain MNK-eIF4E signalling axis contribute to diurnal rhythms of some cognitive functions. Eur J Neurosci. 2022 Jul;56(1):3553-3569
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory