Selenop Gene Detail

Summary

• Symbol
  Selenop
• Name
  selenoprotein P
• Synonyms
  D15Ucla1, selp, Se-P, Sepp1

• Feature Type
  protein coding gene
• IDs
  MGI:894288
  NCBI Gene: 20363
• Alliance
  gene page
• Transcription Start Sites
  38 TSS

Location &
Maps

• Sequence Map
  Chr15:3300249-3309992 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 1.84 cM
• Mapping Data
  7 experiments

Strain
Comparison

• SNPs within 2kb
  265 from dbSNP Build 142
• Strain Annotations
  18
• RFLP
  1

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_894288	protein coding gene	Chr15:3298029-3309992 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021680	protein coding gene	Chr15:113119-128004 (+)
A/J	MGP_AJ_G0021640	protein coding gene	Chr15:129623-142648 (+)
AKR/J	MGP_AKRJ_G0021618	protein coding gene	Chr15:132541-144500 (+)
BALB/cJ	MGP_BALBcJ_G0021647	protein coding gene	Chr15:127194-139177 (+)
C3H/HeJ	MGP_C3HHeJ_G0021423	protein coding gene	Chr15:114123-126093 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022086	protein coding gene	Chr15:155981-173007 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019624	protein coding gene	Chr15:95451-107316 (+)
CAST/EiJ	MGP_CASTEiJ_G0020939	protein coding gene	Chr15:165226-178066 (+)
CBA/J	MGP_CBAJ_G0021392	protein coding gene	Chr15:149344-161340 (+)
DBA/2J	MGP_DBA2J_G0021516	protein coding gene	Chr15:110175-123193 (+)
FVB/NJ	MGP_FVBNJ_G0021494	protein coding gene	Chr15:101592-113813 (+)
LP/J	MGP_LPJ_G0021583	protein coding gene	Chr15:104030-116093 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021520	protein coding gene	Chr15:147774-162531 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022109	protein coding gene	Chr15:126253-138227 (+)
PWK/PhJ	MGP_PWKPhJ_G0020683	protein coding gene	Chr15:162375-174549 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020521	protein coding gene	Chr15:186411-198590 (+)
WSB/EiJ	MGP_WSBEiJ_G0020995	protein coding gene	Chr15:109625-122347 (+)

Homology

• Human Ortholog
  SELENOP, selenoprotein P

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  SELENOP, selenoprotein P
  
• Synonyms
  SELP, SeP, SEPP, SEPP1
• Links
  HGNC:10751

  NCBI Gene ID: 6414

  neXtProt AC: NX_P49908

  UniProt: P49908

  
  
• Chr Location
  5p12; chr5:42799880-42887392 (-)  GRCh38

---

• MGI Vertebrate Homology
  Selenop stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: SELENOP
• Gene Tree
  Selenop
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  36 phenotypes from 4 alleles in 5 genetic backgrounds
  1 phenotype from multigenic genotypes
  2 images
  52 phenotype references
  

• All Mutations and Alleles
  14
• Endonuclease-mediated
  4
• Gene trapped
  1
• Targeted
  9
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  24 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit ataxia, spasticity, impaired growth, reduced male fertility, and excess mortality.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  19
• GO References
  8

Expression

• Assay Results
  998
• Tissues
  198
• cDNA Data
  655
• Literature Summary
  17

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase selenop1
  ZFIN selenop

Sequences &
Gene Models

• All Sequences
  90
• RefSeq
  6
• UniProt
  4
• CCDS
  CCDS27357.1

• Ensembl
  ENSMUSG00000064373 (Evidence)
• NCBI Gene
  20363

Representative Sequences			Length	Strain/Species
genomic	20363	NCBI Gene Model | MGI Sequence Detail	9744	C57BL/6J
transcript	NM_001042614	RefSeq | MGI Sequence Detail	2118	ZRU/MplStud
polypeptide	P70274	UniProt | EBI | MGI Sequence Detail	380	Not Applicable

Protein
Information

• UniProt
  4 Sequences
• Protein Ontology
  PR:000014646 selenoprotein P
  (term hierarchy)
• InterPro Domains
  IPR037941 Selenoprotein P
  IPR007672 Selenoprotein P, C-terminal
  IPR007671 Selenoprotein P, N-terminal
• GlyGen
  P70274 5 sites, 2 N-linked glycans (2 sites)

Molecular
Reagents

• All nucleic 663

  cDNA 655

  Primer pair 6

  Other 2

  
  

  Microarray probesets 2

Other
Accession IDs

MGD-MRK-4226, MGI:2146129, MGI:90427

References

• Summaries
  All 104

  Developmental Gene Expression 17

  Gene Ontology 8

  Phenotypes 52
• Earliest
  J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
• Latest
  J:353939 Abuduwaili H, et al., Selenoprotein P deficiency protects against immobilization-induced muscle atrophy by suppressing atrophy-related E3 ubiquitin ligases. Am J Physiol Endocrinol Metab. 2023 Jun 1;324(6):E542-E552

TSS for Selenop:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130380	Chr15:3300453-3300488 (+)	222 bp
Tssr130381	Chr15:3300872-3300892 (+)	633 bp
Tssr130382	Chr15:3302641-3302675 (+)	2,409 bp
Tssr130383	Chr15:3304136-3304153 (+)	3,896 bp
Tssr130384	Chr15:3304160-3304173 (+)	3,918 bp
Tssr130385	Chr15:3304183-3304277 (+)	3,981 bp
Tssr130386	Chr15:3304281-3304327 (+)	4,055 bp
Tssr130387	Chr15:3304353-3304367 (+)	4,111 bp
Tssr130388	Chr15:3304371-3304385 (+)	4,129 bp
Tssr130389	Chr15:3304513-3304524 (+)	4,270 bp
Tssr130390	Chr15:3304693-3304704 (+)	4,450 bp
Tssr130391	Chr15:3305038-3305073 (+)	4,807 bp
Tssr130392	Chr15:3305075-3305147 (+)	4,862 bp
Tssr130393	Chr15:3305151-3305185 (+)	4,919 bp
Tssr130394	Chr15:3305190-3305211 (+)	4,952 bp
Tssr130395	Chr15:3306634-3306677 (+)	6,407 bp
Tssr130396	Chr15:3306693-3306714 (+)	6,455 bp
Tssr130397	Chr15:3308603-3308612 (+)	8,359 bp
Tssr130398	Chr15:3308639-3308665 (+)	8,403 bp
Tssr4538	Chr15:3308739-3308742 (+)	8,492 bp
Tssr130399	Chr15:3308747-3308754 (+)	8,502 bp
Tssr130400	Chr15:3308767-3308778 (+)	8,524 bp
Tssr130401	Chr15:3308781-3308786 (+)	8,535 bp
Tssr130402	Chr15:3308849-3308850 (+)	8,601 bp
Tssr130403	Chr15:3308881-3308897 (+)	8,640 bp
Tssr130404	Chr15:3308921-3308939 (+)	8,681 bp
Tssr130405	Chr15:3308941-3308957 (+)	8,700 bp
Tssr130406	Chr15:3308972-3308983 (+)	8,729 bp
Tssr130407	Chr15:3309006-3309019 (+)	8,764 bp
Tssr130408	Chr15:3309042-3309049 (+)	8,797 bp
Tssr130409	Chr15:3309051-3309066 (+)	8,810 bp
Tssr130410	Chr15:3309072-3309092 (+)	8,833 bp
Tssr130411	Chr15:3309128-3309140 (+)	8,885 bp
Tssr130412	Chr15:3309203-3309221 (+)	8,963 bp
Tssr130413	Chr15:3309456-3309459 (+)	9,209 bp
Tssr130414	Chr15:3309504-3309513 (+)	9,260 bp
Tssr130415	Chr15:3309578-3309590 (+)	9,335 bp
Tssr130416	Chr15:3309875-3309880 (+)	9,629 bp