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Pirb Gene Detail
Summary
  • Symbol
    Pirb
  • Name
    paired Ig-like receptor B
  • Synonyms
    Gp91, Lilrb3
  • Feature Type
    protein coding gene
  • IDs
    MGI:894311
    NCBI Gene: 18733
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:3715504-3723381 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 2.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    246 from dbSNP Build 142
  • Strain Annotations
    12
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894311
 protein coding gene Chr7:3714408-3723390 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031531
 protein coding gene Chr7:643471-655545 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0031434
 protein coding gene Chr7:593439-847837 (-)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0031234
 protein coding gene Chr7:605005-608229 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031974
 protein coding gene Chr7:618568-765734 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0031354
 protein coding gene Chr7:774448-810249 (-)
FVB/NJ MGP_FVBNJ_G0031305
 protein coding gene Chr7:586875-612483 (-)
LP/J MGP_LPJ_G0031436
 protein coding gene Chr7:661676-900843 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031342
 protein coding gene Chr7:643362-651522 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032008
 protein coding gene Chr7:589713-592893 (-)
PWK/PhJ MGP_PWKPhJ_G0030330
 protein coding gene Chr7:725707-729353 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0030697
 protein coding gene Chr7:591509-595185 (-)



Homology
more
  • Human Ortholog
    LILRA3, leukocyte immunoglobulin like receptor A3
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LILRA3, leukocyte immunoglobulin like receptor A3
  • Synonyms
    CD85E, HM31, HM43, ILT-6, ILT6, LIR-4, LIR4
  • Links
    NCBI Gene ID: 11026
    neXtProt AC: NX_Q8N6C8
    UniProt: Q8N6C8

  • Chr Location
    19q13.4
  • Human Ortholog
    LILRB1, leukocyte immunoglobulin like receptor B1
  • Synonyms
    CD85J, ILT-2, ILT2, LIR-1, LIR1, MIR-7, MIR7, PIR-B, PIRB
  • Links
    NCBI Gene ID: 10859
    neXtProt AC: NX_Q8NHL6
    UniProt: Q8NHL6

  • Chr Location
    19q13.42; chr19:54616322-54638022 (+)  GRCh38
  • Human Ortholog
    LILRB2, leukocyte immunoglobulin like receptor B2
  • Synonyms
    CD85D, ILT-4, ILT4, LIR-2, LIR2, MIR-10, MIR10
  • Links
    NCBI Gene ID: 10288
    neXtProt AC: NX_Q8N423
    UniProt: Q8N423

  • Chr Location
    19q13.42; chr19:54273812-54281184 (-)  GRCh38
  • Human Ortholog
    LILRB3, leukocyte immunoglobulin like receptor B3
  • Synonyms
    CD85A, HL9, ILT-5, ILT5, LILRA6, LIR-3, LIR3, PIR-B, PIRB
  • Links
    NCBI Gene ID: 11025
    neXtProt AC: NX_O75022
    UniProt: O75022

  • Chr Location
    19q13.42; chr19:54216278-54223506 (-)  GRCh38
  • Human Ortholog
    LILRB5, leukocyte immunoglobulin like receptor B5
  • Synonyms
    CD85C, LIR-8, LIR8
  • Links
    NCBI Gene ID: 10990
    neXtProt AC: NX_O75023
    UniProt: O75023

  • Chr Location
    19q13.42; chr19:54249421-54257301 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene display abnormalities in both B and T lymphocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    7
  • cDNA Data
    19
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18733 NCBI Gene Model | MGI Sequence Detail 7878 C57BL/6J ±  kb
    transcript NM_001357394 RefSeq | MGI Sequence Detail 2735 ZRU/MplStud  
    polypeptide P97484 UniProt | EBI | MGI Sequence Detail 841 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 19

      Microarray probesets 5
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 46
    • Earliest
      J:39238 Hayami K, et al., Molecular cloning of a novel murine cell-surface glycoprotein homologous to killer cell inhibitory receptors. J Biol Chem. 1997 Mar 14;272(11):7320-7
    • Latest
      J:340673 Pinho S, et al., VCAM1 confers innate immune tolerance on haematopoietic and leukaemic stem cells. Nat Cell Biol. 2022 Mar;24(3):290-298
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory