Rab6a MGI Mouse Gene Detail - MGI:894313 - RAB6A, member RAS oncogene family

Symbol

Rab6a
Name

RAB6A, member RAS oncogene family
Synonyms

2610028L11Rik, Rab6

Feature Type

protein coding gene
IDs

MGI:894313
NCBI Gene: 19346
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr7:100256778-100290475 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.36 cM, cytoband C4
Mapping Data

3 experiments

SNPs within 2kb

633 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_894313	protein coding gene	Chr7:100256617-100290475 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032574	protein coding gene	Chr7:103499031-103537372 (+)
A/J	MGP_AJ_G0032548	protein coding gene	Chr7:100889263-100926082 (+)
AKR/J	MGP_AKRJ_G0032484	protein coding gene	Chr7:103291792-103329047 (+)
BALB/cJ	MGP_BALBcJ_G0032559	protein coding gene	Chr7:100575350-100608931 (+)
C3H/HeJ	MGP_C3HHeJ_G0032274	protein coding gene	Chr7:103673942-103708537 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033057	protein coding gene	Chr7:107424672-107463550 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030051	protein coding gene	Chr7:103289104-103323011 (+)
CAST/EiJ	MGP_CASTEiJ_G0031601	protein coding gene	Chr7:95228820-95273210 (+)
CBA/J	MGP_CBAJ_G0032241	protein coding gene	Chr7:111127232-111162355 (+)
DBA/2J	MGP_DBA2J_G0032392	protein coding gene	Chr7:99226917-99260456 (+)
FVB/NJ	MGP_FVBNJ_G0032349	protein coding gene	Chr7:99005613-99039792 (+)
LP/J	MGP_LPJ_G0032482	protein coding gene	Chr7:104847842-104884902 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032382	protein coding gene	Chr7:112534864-112572563 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033079	protein coding gene	Chr7:102558711-102594296 (+)
PWK/PhJ	MGP_PWKPhJ_G0031319	protein coding gene	Chr7:92345166-92379685 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031162	protein coding gene	Chr7:89873477-89908268 (+)
WSB/EiJ	MGP_WSBEiJ_G0031718	protein coding gene	Chr7:103261056-103298522 (+)

Human Ortholog

RAB6A, RAB6A, member RAS oncogene family

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAB6A, RAB6A, member RAS oncogene family
Synonyms

RAB6
Links

HGNC:9786

NCBI Gene ID: 5870

neXtProt AC: NX_P20340

UniProt: P20340
Chr Location

11q13.4; chr11:73675638-73761137 (-) GRCh38

MGI Vertebrate Homology

Rab6a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RAB6A
Gene Tree

Rab6a

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Phenotype Summary

4 phenotypes from 1 allele in 2 genetic backgrounds
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

11
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Rab6a
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele die aroound E6 with disorganized epiblast.

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All GO Annotations

51
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

843
Tissues

39
cDNA Data

231
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rab6a

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All Sequences

70
RefSeq

5
UniProt

4
CCDS

CCDS21503.1, CCDS52323.1

Ensembl

ENSMUSG00000030704 (Evidence)
NCBI Gene

19346

			Length	Strain/Species	Flank
genomic	19346	NCBI Gene Model \| MGI Sequence Detail	33698	C57BL/6J	± kb
transcript	NM_001163663	RefSeq \| MGI Sequence Detail	3046	C57BL/6
polypeptide	P35279	UniProt \| EBI \| MGI Sequence Detail	208	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013636 Ras-related protein Rab-6A

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR050227 Ras-related protein Rab

IPR001806 Small GTPase

IPR005225 Small GTP-binding protein domain
GlyGen

P35279 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 232

cDNA 232

Microarray probesets 7

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MGI:1925564, MGI:2141829

Summaries

All 73

Developmental Gene Expression 9

Gene Ontology 13

Phenotypes 24
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:354356 Zhang Y, et al., Rab6-Mediated Polarized Transport of Synaptic Vesicle Precursors Is Essential for the Establishment of Neuronal Polarity and Brain Formation. J Neurosci. 2024 Jul 3;44(27)

TSS for Rab6a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68160	Chr7:100256763-100256825 (+)	16 bp
Tssr68161	Chr7:100256867-100257030 (+)	171 bp
Tssr68162	Chr7:100257043-100257061 (+)	274 bp
Tssr68163	Chr7:100257094-100257106 (+)	322 bp
Tssr68164	Chr7:100257119-100257199 (+)	381 bp
Tssr68165	Chr7:100288511-100288520 (+)	31,738 bp
Tssr68166	Chr7:100289767-100289790 (+)	33,001 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24