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Cdk14 Gene Detail
Summary
  • Symbol
    Cdk14
  • Name
    cyclin dependent kinase 14
  • Synonyms
    mKIAA0834, Pftk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:894318
    NCBI Gene: 18647
  • Alliance
    gene page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:4853384-5430650 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 2.61 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    17293 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894318
 protein coding gene Chr5:4853384-5470312 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029270
 protein coding gene Chr5:1681723-2330922 (-)
A/J MGP_AJ_G0029233
 protein coding gene Chr5:1598044-2228074 (-)
AKR/J MGP_AKRJ_G0029183
 protein coding gene Chr5:1610355-2263590 (-)
BALB/cJ MGP_BALBcJ_G0029251
 protein coding gene Chr5:1786020-2434241 (-)
C3H/HeJ MGP_C3HHeJ_G0028971
 protein coding gene Chr5:1791668-2464061 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029701
 protein coding gene Chr5:2035957-2704876 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026944
 protein coding gene Chr5:1713703-2288398 (-)
CAST/EiJ MGP_CASTEiJ_G0028384
 protein coding gene Chr5:1765462-2425232 (-)
CBA/J MGP_CBAJ_G0028932
 protein coding gene Chr5:1979218-2676544 (-)
DBA/2J MGP_DBA2J_G0029084
 protein coding gene Chr5:1738200-2377052 (-)
FVB/NJ MGP_FVBNJ_G0029046
 protein coding gene Chr5:1604375-2233832 (-)
LP/J MGP_LPJ_G0029174
 protein coding gene Chr5:1766295-2420394 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029073
 protein coding gene Chr5:1845413-2592796 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029732
 protein coding gene Chr5:1690181-2324171 (-)
PWK/PhJ MGP_PWKPhJ_G0028105
 protein coding gene Chr5:1658883-2305218 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027939
 protein coding gene Chr5:1955962-2622238 (-)
WSB/EiJ MGP_WSBEiJ_G0028464
 protein coding gene Chr5:1703064-2349553 (-)



Homology
more
  • Human Ortholog
    CDK14, cyclin dependent kinase 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDK14, cyclin dependent kinase 14
  • Synonyms
    PFTAIRE1, PFTK1
  • Links
    NCBI Gene ID: 5218
    neXtProt AC: NX_O94921
    UniProt: O94921

  • Chr Location
    7q21.13; chr7:90466424-91210590 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display delayed axon extension in culture.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    903
  • Tissues
    137
  • cDNA Data
    17
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18647 NCBI Gene Model | MGI Sequence Detail 577267 C57BL/6J ±  kb
    transcript NM_011074 RefSeq | MGI Sequence Detail 5308 C57BL/6  
    polypeptide O35495 UniProt | EBI | MGI Sequence Detail 469 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 7
      Gene Ontology 11
      Phenotypes 9
    • Earliest
      J:37806 Lazzaro MA, et al., Chromosomal mapping of the PFTAIRE gene, Pftk1, a cdc2-related kinase expressed predominantly in the mouse nervous system. Genomics. 1997 Jun 15;42(3):536-7
    • Latest
      J:352906 Parmasad JA, et al., Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy. Cell Death Dis. 2024 Apr 4;15(4):246
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory