Tmem165 MGI Mouse Gene Detail - MGI:894407

Symbol

Tmem165
Name

transmembrane protein 165
Synonyms

pFT27, Tpardl, Tparl

Feature Type

protein coding gene
IDs

MGI:894407
NCBI Gene: 21982
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr5:76331727-76357091 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 40.56 cM
Mapping Data

6 experiments

SNPs within 2kb

647 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_894407	protein coding gene	Chr5:76331727-76357092 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029641	protein coding gene	Chr5:76360485-76385135 (+)
A/J	MGP_AJ_G0029609	protein coding gene	Chr5:73436243-73464142 (+)
AKR/J	MGP_AKRJ_G0029557	protein coding gene	Chr5:75823056-75852737 (+)
BALB/cJ	MGP_BALBcJ_G0029618	protein coding gene	Chr5:74181107-74205696 (+)
C3H/HeJ	MGP_C3HHeJ_G0029341	protein coding gene	Chr5:76211470-76239030 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030072	protein coding gene	Chr5:79421868-79451093 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027313	protein coding gene	Chr5:69096227-69124539 (+)
CAST/EiJ	MGP_CASTEiJ_G0028749	protein coding gene	Chr5:75394177-75420186 (+)
CBA/J	MGP_CBAJ_G0029310	protein coding gene	Chr5:82009232-82033798 (+)
DBA/2J	MGP_DBA2J_G0029455	protein coding gene	Chr5:73513275-73545147 (+)
FVB/NJ	MGP_FVBNJ_G0029416	protein coding gene	Chr5:72691546-72719822 (+)
LP/J	MGP_LPJ_G0029542	protein coding gene	Chr5:76801219-76825931 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029444	protein coding gene	Chr5:85191079-85219568 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030105	protein coding gene	Chr5:75391047-75416638 (+)
PWK/PhJ	MGP_PWKPhJ_G0028472	protein coding gene	Chr5:72519739-72549042 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028307	protein coding gene	Chr5:74750760-74782119 (+)
WSB/EiJ	MGP_WSBEiJ_G0028829	protein coding gene	Chr5:75695720-75724444 (+)

Human Ortholog

TMEM165, transmembrane protein 165

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM165, transmembrane protein 165
Synonyms

CDG2K, FT27, GDT1, SLC64A1, TMPT27, TPARL
Links

HGNC:30760

NCBI Gene ID: 55858

neXtProt AC: NX_Q9HC07

UniProt: Q9HC07
Chr Location

4q12; chr4:55395957-55453397 (+) GRCh38

MGI Vertebrate Homology

Tmem165 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM165
Gene Tree

Tmem165

Diseases

1 with human TMEM165 associations

				Human Disease	Mouse Models
				congenital disorder of glycosylation type IIk IDs congenital disorder of glycosylation type IIk DOID:0070263 OMIM:614727 ORDO:314667

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

2
Endonuclease-mediated

5
Gene trapped

2
Spontaneous

2
Targeted

3
Genomic Mutations

5 involving Tmem165
Incidental Mutations

APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

33
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

123

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem165

ZFIN tmem165

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All Sequences

48
RefSeq

2
UniProt

3
CCDS

CCDS19359.1

Ensembl

ENSMUSG00000029234 (Evidence)
NCBI Gene

21982

			Length	Strain/Species	Flank
genomic	21982	NCBI Gene Model \| MGI Sequence Detail	25365	C57BL/6J	± kb
transcript	NM_011626	RefSeq \| MGI Sequence Detail	1896	C57BL/6
polypeptide	P52875	UniProt \| EBI \| MGI Sequence Detail	323	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000031748 putative divalent cation/proton antiporter TMEM165

(term hierarchy)
InterPro Domains

IPR001727 GDT1-like

IPR049555 GDT1-like, conserved site

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All nucleic 127

Genomic 4

cDNA 123

Microarray probesets 4

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MGI:2141106

Summaries

All 49

Gene Ontology 8

Phenotypes 17
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmem165:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46721	Chr5:76331762-76331817 (+)	63 bp
Tssr46722	Chr5:76353710-76353725 (+)	21,991 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24