Hbp1 MGI Mouse Gene Detail - MGI:894659 - high mobility group box transcription factor 1

Symbol

Hbp1
Name

high mobility group box transcription factor 1
Synonyms

1700058O05Rik, C330012F01Rik, C86454

Feature Type

protein coding gene
IDs

MGI:894659
NCBI Gene: 73389
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr12:31976449-32000529 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 13.73 cM
Mapping Data

2 experiments

SNPs within 2kb

553 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_894659	protein coding gene	Chr12:31976253-32000534 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019667	protein coding gene	Chr12:29910678-29936183 (-)
A/J	MGP_AJ_G0019634	protein coding gene	Chr12:29055819-29080077 (-)
AKR/J	MGP_AKRJ_G0019605	protein coding gene	Chr12:29979545-30004651 (-)
BALB/cJ	MGP_BALBcJ_G0019611	protein coding gene	Chr12:29279349-29303574 (-)
C3H/HeJ	MGP_C3HHeJ_G0019415	protein coding gene	Chr12:29855227-29879986 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020058	protein coding gene	Chr12:30838249-30866198 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017683	protein coding gene	Chr12:28343535-28370706 (-)
CAST/EiJ	MGP_CASTEiJ_G0018970	protein coding gene	Chr12:24851184-24882857 (-)
CBA/J	MGP_CBAJ_G0019387	protein coding gene	Chr12:31830244-31860742 (-)
DBA/2J	MGP_DBA2J_G0019500	protein coding gene	Chr12:28878594-28903931 (-)
FVB/NJ	MGP_FVBNJ_G0019491	protein coding gene	Chr12:28674298-28698685 (-)
LP/J	MGP_LPJ_G0019570	protein coding gene	Chr12:30002446-30027764 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019526	protein coding gene	Chr12:31475938-31504417 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020098	protein coding gene	Chr12:29509756-29534085 (-)
PWK/PhJ	MGP_PWKPhJ_G0018737	protein coding gene	Chr12:23620738-23646995 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018525	protein coding gene	Chr12:24094410-24121660 (-)
WSB/EiJ	MGP_WSBEiJ_G0019020	protein coding gene	Chr12:29745332-29769664 (-)

Human Ortholog

HBP1, HMG-box transcription factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HBP1, HMG-box transcription factor 1
Links

HGNC:23200

NCBI Gene ID: 26959

neXtProt AC: NX_O60381

UniProt: O60381
Chr Location

7q22.3; chr7:107168961-107202522 (+) GRCh38

MGI Vertebrate Homology

Hbp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HBP1
Gene Tree

Hbp1

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Endonuclease-mediated

3
Gene trapped

24
Targeted

5
Incidental Mutations

CvDC
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice heterozygous for a gene trapped allele have behavioral abnormalities and show alterations in leukocyte, platelet and NK cell number, blood urea nitrogen levels, and circulating amylase and calcium levels.

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All GO Annotations

20
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

867
Tissues

97
cDNA Data

29
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hbp1

ZFIN hbp1

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All Sequences

88
RefSeq

18
UniProt

10
CCDS

CCDS25867.2, CCDS25868.2

Ensembl

ENSMUSG00000002996 (Evidence)
NCBI Gene

73389

			Length	Strain/Species	Flank
genomic	73389	NCBI Gene Model \| MGI Sequence Detail	24081	C57BL/6J	± kb
transcript	NM_177993	RefSeq \| MGI Sequence Detail	2753	C57BL/6
polypeptide	Q8R316	UniProt \| EBI \| MGI Sequence Detail	516	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000008463 HMG box-containing protein 1

(term hierarchy)
PDB

1S5R, 1V06
InterPro Domains

IPR003652 Ataxin, AXH domain

IPR036096 Ataxin, AXH domain superfamily

IPR009071 High mobility group box domain

IPR036910 High mobility group box domain superfamily

IPR039655 HMG box-containing protein 1
GlyGen

Q8R316 1 site, 1 O-linked glycan (1 site)

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All nucleic 39

cDNA 31

Primer pair 8

Microarray probesets 7

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MGI:1920639, MGI:1924485, MGI:3034670, MGI:3034710

Summaries

All 57

Developmental Gene Expression 11

Gene Ontology 9

Phenotypes 13
Earliest

J:38319 Tevosian SG, et al., HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family. Genes Dev. 1997 Feb 1;11(3):383-96
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Hbp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116062	Chr12:32000551-32000559 (-)	-26 bp
Tssr116061	Chr12:32000212-32000245 (-)	300 bp
Tssr116060	Chr12:32000185-32000196 (-)	338 bp
Tssr116059	Chr12:31998768-31998773 (-)	1,758 bp
Tssr116058	Chr12:31994529-31994530 (-)	5,999 bp
Tssr116057	Chr12:31978796-31978800 (-)	21,731 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24