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Aurka Gene Detail
Summary
  • Symbol
    Aurka
  • Name
    aurora kinase A
  • Synonyms
    AIRK1, Ark1, aurora A, Aurora-A, Ayk1, IAK, IAK1, Stk6
  • Feature Type
    protein coding gene
  • IDs
    MGI:894678
    NCBI Gene: 20878
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:172198110-172212455 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 94.84 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    567 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894678
 protein coding gene Chr2:172198110-172212825 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026942
 protein coding gene Chr2:178526463-178544323 (-)
A/J MGP_AJ_G0026909
 protein coding gene Chr2:171050765-171064699 (-)
AKR/J MGP_AKRJ_G0026880
 protein coding gene Chr2:176211643-176225982 (-)
BALB/cJ MGP_BALBcJ_G0026918
 protein coding gene Chr2:171440915-171455240 (-)
C3H/HeJ MGP_C3HHeJ_G0026660
 protein coding gene Chr2:176566906-176581220 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027365
 protein coding gene Chr2:183686201-183702807 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024735
 protein coding gene Chr2:164300258-164314724 (-)
CAST/EiJ MGP_CASTEiJ_G0026118
 protein coding gene Chr2:177228132-177242623 (-)
CBA/J MGP_CBAJ_G0026637
 protein coding gene Chr2:190542243-190559910 (-)
DBA/2J MGP_DBA2J_G0026775
 protein coding gene Chr2:170145552-170159881 (-)
FVB/NJ MGP_FVBNJ_G0026741
 protein coding gene Chr2:168742020-168756425 (-)
LP/J MGP_LPJ_G0026876
 protein coding gene Chr2:178457177-178471688 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026760
 protein coding gene Chr2:193532934-193547275 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027422
 protein coding gene Chr2:176172840-176187926 (-)
PWK/PhJ MGP_PWKPhJ_G0025855
 protein coding gene Chr2:169901231-169916168 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025655
 protein coding gene Chr2:175176724-175191454 (-)
WSB/EiJ MGP_WSBEiJ_G0026191
 protein coding gene Chr2:177150051-177166053 (-)



Homology
more
  • Human Ortholog
    AURKA, aurora kinase A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AURKA, aurora kinase A
  • Synonyms
    AIK, ARK1, AURA, BTAK, PPP1R47, STK15, STK6, STK7
  • Links
    NCBI Gene ID: 6790
    neXtProt AC: NX_O14965
    UniProt: O14965

  • Chr Location
    20q13.2
Human Diseases
more
  • Diseases
    3 with human AURKA associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 6 alleles in 8 genetic backgrounds
    5 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display embryonic lethality before implantation, early embryonic growth arrest, and impaired mitosis. Heterozygous null mice display increased incidence of tumors primarily lymphomas and chromosomal instability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    120
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    853
  • Tissues
    58
  • cDNA Data
    24
  • Literature Summary
    34
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027496 Ensembl Gene Model | MGI Sequence Detail 14346 C57BL/6J ±  kb
    transcript ENSMUST00000028997 Ensembl | MGI Sequence Detail 1905 Not Applicable  
    polypeptide ENSMUSP00000028997 Ensembl | MGI Sequence Detail 417 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 25
      Primer pair 6
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139176, MGI:2139368
    References
    more
    • Summaries
      All 133
      Developmental Gene Expression 34
      Gene Ontology 25
      Phenotypes 27
    • Earliest
      J:5970 Ferguson JM, et al., A new type of chondrodystrophic mutant in the mouse. J Med Genet. 1978 Apr;15(2):128-31
    • Latest
      J:350882 Tham MS, et al., Deletion of Aurora kinase A prevents the development of polycystic kidney disease in mice. Nat Commun. 2024 Jan 8;15(1):371
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory