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Bach2 Gene Detail
Summary
  • Symbol
    Bach2
  • Name
    BTB and CNC homology, basic leucine zipper transcription factor 2
  • Synonyms
    E030004N02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:894679
    NCBI Gene: 12014
  • Alliance
    gene page
  • Transcription Start Sites
    35 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:32238804-32586108 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 14.02 cM, cytoband A4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9147 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894679
 protein coding gene Chr4:32238413-32586109 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028109
 protein coding gene Chr4:29685224-30042463 (+)
A/J MGP_AJ_G0028067
 protein coding gene Chr4:28632009-28990541 (+)
AKR/J MGP_AKRJ_G0028031
 protein coding gene Chr4:29386010-29740808 (+)
BALB/cJ MGP_BALBcJ_G0028078
 protein coding gene Chr4:28878946-29238368 (+)
C3H/HeJ MGP_C3HHeJ_G0027808
 protein coding gene Chr4:29662902-30022633 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028520
 protein coding gene Chr4:30863347-31225525 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025862
 protein coding gene Chr4:26689179-27035263 (+)
CAST/EiJ MGP_CASTEiJ_G0027262
 protein coding gene Chr4:29423636-29789555 (+)
CBA/J MGP_CBAJ_G0027780
 protein coding gene Chr4:31833592-32223130 (+)
DBA/2J MGP_DBA2J_G0027924
 protein coding gene Chr4:28646785-28995199 (+)
FVB/NJ MGP_FVBNJ_G0027889
 protein coding gene Chr4:28061989-28415091 (+)
LP/J MGP_LPJ_G0028032
 protein coding gene Chr4:29775363-30138807 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027922
 protein coding gene Chr4:34462934-34830175 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028579
 protein coding gene Chr4:29370773-29727176 (+)
PWK/PhJ MGP_PWKPhJ_G0026982
 protein coding gene Chr4:28595241-28953099 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026810
 protein coding gene Chr4:29244998-29603485 (+)
WSB/EiJ MGP_WSBEiJ_G0027339
 protein coding gene Chr4:29383381-29743388 (+)



Homology
more
  • Human Ortholog
    BACH2, BTB domain and CNC homolog 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BACH2, BTB domain and CNC homolog 2
  • Synonyms
    BTBD25, IMD60
  • Links
    NCBI Gene ID: 60468
    neXtProt AC: NX_Q9BYV9
    UniProt: Q9BYV9

  • Chr Location
    6q15; chr6:89926528-90296843 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human BACH2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    81 phenotypes from 6 alleles in 6 genetic backgrounds
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display impaired B cell differentiation and reduced B cell numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    938
  • Tissues
    136
  • cDNA Data
    58
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040270 Ensembl Gene Model | MGI Sequence Detail 347305 C57BL/6J ±  kb
    transcript ENSMUST00000108180 Ensembl | MGI Sequence Detail 8882 Not Applicable  
    polypeptide ENSMUSP00000103815 Ensembl | MGI Sequence Detail 839 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 59
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2442959
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 13
      Gene Ontology 5
      Phenotypes 59
    • Earliest
      J:41872 Oyake T, et al., Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Mol Cell Biol. 1996 Nov;16(11):6083-95
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory