Xrn2 MGI Mouse Gene Detail - MGI:894687

Symbol

Xrn2
Name

5'-3' exoribonuclease 2

Feature Type

protein coding gene
IDs

MGI:894687
NCBI Gene: 24128
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr2:146854916-146919920 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 72.63 cM, cytoband H1
Mapping Data

3 experiments

SNPs within 2kb

1362 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_894687	protein coding gene	Chr2:146854672-146919922 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026601	protein coding gene	Chr2:151261804-151334485 (+)
A/J	MGP_AJ_G0026565	protein coding gene	Chr2:145118526-145184785 (+)
AKR/J	MGP_AKRJ_G0026539	protein coding gene	Chr2:149371480-149444452 (+)
BALB/cJ	MGP_BALBcJ_G0026577	protein coding gene	Chr2:145557682-145622940 (+)
C3H/HeJ	MGP_C3HHeJ_G0026320	protein coding gene	Chr2:149816976-149884552 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027022	protein coding gene	Chr2:155676588-155751161 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024400	protein coding gene	Chr2:139194732-139259459 (+)
CAST/EiJ	MGP_CASTEiJ_G0025781	protein coding gene	Chr2:150178631-150247682 (+)
CBA/J	MGP_CBAJ_G0026300	protein coding gene	Chr2:161373554-161444840 (+)
DBA/2J	MGP_DBA2J_G0026434	protein coding gene	Chr2:144395666-144461045 (+)
FVB/NJ	MGP_FVBNJ_G0026398	protein coding gene	Chr2:142928848-142996122 (+)
LP/J	MGP_LPJ_G0026538	protein coding gene	Chr2:151400917-151469295 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026418	protein coding gene	Chr2:165524277-165593183 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027077	protein coding gene	Chr2:149316682-149384066 (+)
PWK/PhJ	MGP_PWKPhJ_G0025517	protein coding gene	Chr2:144084063-144148364 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025318	protein coding gene	Chr2:148305881-148373732 (+)
WSB/EiJ	MGP_WSBEiJ_G0025855	protein coding gene	Chr2:150268610-150339066 (+)

Human Ortholog

XRN2, 5'-3' exoribonuclease 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

XRN2, 5'-3' exoribonuclease 2
Links

HGNC:12836

NCBI Gene ID: 22803

neXtProt AC: NX_Q9H0D6

UniProt: Q9H0D6
Chr Location

20p11.22; chr20:21303331-21389825 (+) GRCh38

MGI Vertebrate Homology

Xrn2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: XRN2
Protein SuperFamily

Exonuclease_Xrn2
Gene Tree

Xrn2

Diseases

2 with human XRN2 associations

				Human Disease	Mouse Models
				adenoid cystic carcinoma IDs adenoid cystic carcinoma DOID:0080202 MESH:D003528 NCI:C2970
				lung cancer IDs lung cancer DOID:1324 DOID:13075 DOID:1322 DOID:9881 ICD10CM:C34.1 ICD10CM:C34.2 ICD10CM:C34.3 ICD9CM:162.3 ICD9CM:162.4 ICD9CM:162.5 ICD9CM:162.8 OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 UMLS_CUI:C0024624 UMLS_CUI:C0153491 UMLS_CUI:C0153492 UMLS_CUI:C0153493

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotype references

All Mutations and Alleles

28
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

21
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Xrn2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

54 strains or lines available

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All GO Annotations

34
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

193
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase xrn2

ZFIN xrn2

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All Sequences

56
RefSeq

10
UniProt

1
CCDS

CCDS38258.1

Ensembl

ENSMUSG00000027433 (Evidence)
NCBI Gene

24128

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027433	Ensembl Gene Model \| MGI Sequence Detail	65005	C57BL/6J	± kb
transcript	ENSMUST00000028921	Ensembl \| MGI Sequence Detail	3434	Not Applicable
polypeptide	ENSMUSP00000028921	Ensembl \| MGI Sequence Detail	951	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000017512 5'-3' exoribonuclease 2

(term hierarchy)
EC

3.1.13.-
InterPro Domains

IPR027073 5'-3' exoribonuclease

IPR017151 5'-3' exoribonuclease type 2

IPR041412 Xrn1, helical domain

IPR004859 Xrn1, N-terminal
GlyGen

Q9DBR1 1 site, 1 O-linked glycan (1 site)

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All nucleic 194

cDNA 194

Microarray probesets 5

Summaries

All 45

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 14
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:342028 Krishnan R, et al., RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells. Nucleic Acids Res. 2023 Oct 27;51(19):10484-10505

TSS for Xrn2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20617	Chr2:146854664-146854714 (+)	-227 bp
Tssr20618	Chr2:146854933-146855003 (+)	52 bp
Tssr20619	Chr2:146855778-146855787 (+)	867 bp
Tssr20620	Chr2:146855842-146855852 (+)	931 bp
Tssr20621	Chr2:146856680-146856684 (+)	1,766 bp
Tssr20622	Chr2:146871783-146871798 (+)	16,875 bp
Tssr20623	Chr2:146888889-146888893 (+)	33,975 bp
Tssr20624	Chr2:146914516-146914520 (+)	59,602 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24