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Rad54l Gene Detail
Summary
  • Symbol
    Rad54l
  • Name
    RAD54 like (S. cerevisiae)
  • Synonyms
    RAD54
  • Feature Type
    protein coding gene
  • IDs
    MGI:894697
    NCBI Gene: 19366
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:115951458-115980875 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    714 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894697
 protein coding gene Chr4:115951458-115980887 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028618
 protein coding gene Chr4:116943569-116974829 (-)
A/J MGP_AJ_G0028579
 protein coding gene Chr4:112487593-112516822 (-)
AKR/J MGP_AKRJ_G0028529
 protein coding gene Chr4:114899430-114930785 (-)
BALB/cJ MGP_BALBcJ_G0028600
 protein coding gene Chr4:113120131-113149110 (-)
C3H/HeJ MGP_C3HHeJ_G0028314
 protein coding gene Chr4:116478478-116508247 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029041
 protein coding gene Chr4:121493633-121525221 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026325
 protein coding gene Chr4:106528260-106558940 (-)
CAST/EiJ MGP_CASTEiJ_G0027748
 protein coding gene Chr4:113705416-113734418 (-)
CBA/J MGP_CBAJ_G0028281
 protein coding gene Chr4:124794674-124826047 (-)
DBA/2J MGP_DBA2J_G0028429
 protein coding gene Chr4:113131445-113160472 (-)
FVB/NJ MGP_FVBNJ_G0028397
 protein coding gene Chr4:111627551-111658155 (-)
LP/J MGP_LPJ_G0028531
 protein coding gene Chr4:117156811-117191336 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028424
 protein coding gene Chr4:129794423-129824660 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029078
 protein coding gene Chr4:116060996-116090556 (-)
PWK/PhJ MGP_PWKPhJ_G0027474
 protein coding gene Chr4:109899842-109928959 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027297
 protein coding gene Chr4:112313652-112341997 (-)
WSB/EiJ MGP_WSBEiJ_G0027827
 protein coding gene Chr4:115931342-115963174 (-)



Homology
more
  • Human Ortholog
    RAD54L, RAD54 like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAD54L, RAD54 like
  • Synonyms
    hHR54, HR54, hRAD54, RAD54A
  • Links
    NCBI Gene ID: 8438
    neXtProt AC: NX_Q92698
    UniProt: Q92698

  • Chr Location
    1p34.1; chr1:46246461-46278480 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rad54l mouse models; 4 with human RAD54L associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are sensitive to DNA crosslinking agents and to ionizing radiation and show abnormal definitive hematopoiesis following X-ray treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    15
  • cDNA Data
    8
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 19366 NCBI Gene Model | MGI Sequence Detail 29418 C57BL/6J ±  kb
transcript NM_009015 RefSeq | MGI Sequence Detail 5758 C57BL/6  
polypeptide P70270 UniProt | EBI | MGI Sequence Detail 747 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    Genomic 1
    cDNA 11
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 74
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 12
    Phenotypes 42
  • Earliest
    J:34999 Kanaar R, et al., Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation. Curr Biol. 1996 Jul 1;6(7):828-38
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory