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Mgat5 Gene Detail
Summary
  • Symbol
    Mgat5
  • Name
    mannoside acetylglucosaminyltransferase 5
  • Synonyms
    4930471A21Rik, 5330407H02Rik, beta1,6N-acetylglucosaminyltransferase V, GlcNAc-TV
  • Feature Type
    protein coding gene
  • IDs
    MGI:894701
    NCBI Gene: 107895
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:127132450-127413760 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 55.71 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7578 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894701
 protein coding gene Chr1:127132450-127416073 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016419
 protein coding gene Chr1:130390806-130696667 (+)
A/J MGP_AJ_G0016402
 protein coding gene Chr1:125543873-125829227 (+)
AKR/J MGP_AKRJ_G0016367
 protein coding gene Chr1:129230005-129525038 (+)
BALB/cJ MGP_BALBcJ_G0016362
 protein coding gene Chr1:125924128-126211306 (+)
C3H/HeJ MGP_C3HHeJ_G0016188
 protein coding gene Chr1:129428017-129717331 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016823
 protein coding gene Chr1:135309684-135612049 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014536
 protein coding gene Chr1:118918107-119199409 (+)
CAST/EiJ MGP_CASTEiJ_G0015769
 protein coding gene Chr1:128388195-128690965 (+)
CBA/J MGP_CBAJ_G0016161
 protein coding gene Chr1:139850778-140179745 (+)
DBA/2J MGP_DBA2J_G0016267
 protein coding gene Chr1:124586095-124871069 (+)
FVB/NJ MGP_FVBNJ_G0016266
 protein coding gene Chr1:123309976-123592420 (+)
LP/J MGP_LPJ_G0016338
 protein coding gene Chr1:131743254-132045588 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016291
 protein coding gene Chr1:145756712-146059501 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016859
 protein coding gene Chr1:129027070-129319487 (+)
PWK/PhJ MGP_PWKPhJ_G0015555
 protein coding gene Chr1:123552330-123839680 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015343
 protein coding gene Chr1:127995355-128286225 (+)
WSB/EiJ MGP_WSBEiJ_G0015831
 protein coding gene Chr1:128974658-129276410 (+)



Homology
more
  • Human Ortholog
    MGAT5, alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MGAT5, alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
  • Synonyms
    glcNAc-T V, GNT-V, GNT-VA, MGAT5A
  • Links
    NCBI Gene ID: 4249
    neXtProt AC: NX_Q09328
    UniProt: Q09328

  • Chr Location
    2q21.2-q21.3; chr2:134119935-134454621 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for deficiencies in this gene have immune system abnormalities and reduced cancer growth and metastasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    101
  • cDNA Data
    12
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107895 NCBI Gene Model | MGI Sequence Detail 281311 C57BL/6J ±  kb
    transcript NM_145128 RefSeq | MGI Sequence Detail 3104 C57BL/6  
    polypeptide Q8R4G6 UniProt | EBI | MGI Sequence Detail 740 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000010384 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
      (term hierarchy)
    • EC
      2.4.1.155
    • InterPro Domains
      IPR052105 Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
      IPR042759 Coiled-coil domain-containing protein 126
      IPR027833 Domain of unknown function DUF4525
      IPR026116 Glycosyltransferase family 18
    • GlyGen
      Q8R4G6 6 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 12
      Primer pair 2
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1923060, MGI:2138276, MGI:2444778
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 39
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:336895 Yale AR, et al., Regulation of neural stem cell differentiation and brain development by MGAT5-mediated N-glycosylation. Stem Cell Reports. 2023 Jun 13;18(6):1340-1354
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory