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Rbbp6 Gene Detail
Summary
  • Symbol
    Rbbp6
  • Name
    retinoblastoma binding protein 6, ubiquitin ligase
  • Synonyms
    4933422O15Rik, C030034J04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:894835
    NCBI Gene: 19647
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:122568980-122601780 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 67.42 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    543 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894835
 protein coding gene Chr7:122564909-122601780 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032958
 protein coding gene Chr7:127081551-127121941 (+)
A/J MGP_AJ_G0032941
 protein coding gene Chr7:123785491-123823838 (+)
AKR/J MGP_AKRJ_G0032873
 protein coding gene Chr7:126945198-126982225 (+)
BALB/cJ MGP_BALBcJ_G0032946
 protein coding gene Chr7:123463874-123567497 (+)
C3H/HeJ MGP_C3HHeJ_G0032656
 protein coding gene Chr7:126832161-126870057 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033452
 protein coding gene Chr7:132059518-132096340 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030424
 protein coding gene Chr7:125083369-125121454 (+)
CAST/EiJ MGP_CASTEiJ_G0031984
 protein coding gene Chr7:118658517-118694080 (+)
CBA/J MGP_CBAJ_G0032629
 protein coding gene Chr7:136488547-136534460 (+)
DBA/2J MGP_DBA2J_G0032781
 protein coding gene Chr7:121775465-121812922 (+)
FVB/NJ MGP_FVBNJ_G0032734
 protein coding gene Chr7:121629897-121667169 (+)
LP/J MGP_LPJ_G0032875
 protein coding gene Chr7:128523512-128568986 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032766
 protein coding gene Chr7:137855254-137896689 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033472
 protein coding gene Chr7:125935484-125978151 (+)
PWK/PhJ MGP_PWKPhJ_G0031692
 protein coding gene Chr7:114717159-114750854 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031538
 protein coding gene Chr7:112721192-112753923 (+)
WSB/EiJ MGP_WSBEiJ_G0032097
 protein coding gene Chr7:126850940-126889372 (+)



Homology
more
  • Human Ortholog
    RBBP6, RB binding protein 6, ubiquitin ligase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBBP6, RB binding protein 6, ubiquitin ligase
  • Synonyms
    MY038, P2P-R, PACT, RBQ-1, SNAMA
  • Links
    NCBI Gene ID: 5930
    neXtProt AC: NX_Q7Z6E9
    UniProt: Q7Z6E9

  • Chr Location
    16p12.1; chr16:24537693-24572863 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality, reduced size, growth retardation and increased apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    7
  • cDNA Data
    117
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19647 NCBI Gene Model | MGI Sequence Detail 32801 C57BL/6J ±  kb
    transcript NM_001403082 RefSeq | MGI Sequence Detail 6926 C57BL/6  
    polypeptide P97868 UniProt | EBI | MGI Sequence Detail 1790 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 118
      cDNA 117
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1344330, MGI:1921709, MGI:1924749, MGI:2141903, MGI:2142301, MGI:2142318
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 8
    • Earliest
      J:38614 Witte MM, et al., The proliferation potential protein-related (P2P-R) gene with domains encoding heterogeneous nuclear ribonucleoprotein association and Rb1 binding shows repressed expression during terminal differentiation. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1212-7
    • Latest
      J:344233 Wu C, et al., Unveiling dysregulated lncRNAs and networks in non-syndromic cleft lip with or without cleft palate pathogenesis. Sci Rep. 2024 Jan 10;14(1):1047
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory