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Acadvl Gene Detail
Summary
  • Symbol
    Acadvl
  • Name
    acyl-Coenzyme A dehydrogenase, very long chain
  • Synonyms
    VLCAD
  • Feature Type
    protein coding gene
  • IDs
    MGI:895149
    NCBI Gene: 11370
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69901009-69906237 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.96 cM, cytoband B2-B5
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    63 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_895149
 protein coding gene Chr11:69901009-69906254 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018578
 protein coding gene Chr11:70509766-70514994 (-)
A/J MGP_AJ_G0018546
 protein coding gene Chr11:67835120-67840348 (-)
AKR/J MGP_AKRJ_G0018515
 protein coding gene Chr11:69856306-69861533 (-)
BALB/cJ MGP_BALBcJ_G0018518
 protein coding gene Chr11:68163874-68169102 (-)
C3H/HeJ MGP_C3HHeJ_G0018331
 protein coding gene Chr11:69895192-69900420 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018969
 protein coding gene Chr11:72626748-72631976 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016614
 protein coding gene Chr11:64759436-64764618 (-)
CAST/EiJ MGP_CASTEiJ_G0017886
 protein coding gene Chr11:70139023-70144245 (-)
CBA/J MGP_CBAJ_G0018303
 protein coding gene Chr11:75886156-75891384 (-)
DBA/2J MGP_DBA2J_G0018413
 protein coding gene Chr11:67419465-67424669 (-)
FVB/NJ MGP_FVBNJ_G0018403
 protein coding gene Chr11:67066708-67071951 (-)
LP/J MGP_LPJ_G0018483
 protein coding gene Chr11:71086139-71091367 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018426
 protein coding gene Chr11:76480322-76485550 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019011
 protein coding gene Chr11:70131450-70136678 (-)
PWK/PhJ MGP_PWKPhJ_G0017660
 protein coding gene Chr11:68072372-68077621 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017450
 protein coding gene Chr11:69946112-69951219 (-)
WSB/EiJ MGP_WSBEiJ_G0017940
 protein coding gene Chr11:69795401-69800635 (-)



Homology
more
  • Human Ortholog
    ACADVL, acyl-CoA dehydrogenase very long chain
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACADVL, acyl-CoA dehydrogenase very long chain
  • Synonyms
    ACAD6, LCACD, VLCAD
  • Links
    NCBI Gene ID: 37
    neXtProt AC: NX_P49748
    UniProt: P49748

  • Chr Location
    17p13.1; chr17:7217125-7225266 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Acadvl mouse models; 1 with human ACADVL associations

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 4 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant animals exhibit mild steatosis, lipid accumulation in myocytes, increased fatigue, impaired temperature regulation, increased susceptibility to arrhythmia, accumulation of long-chain acylcarnitines, and lower free carnitine levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    871
  • Tissues
    106
  • cDNA Data
    271
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018574 Ensembl Gene Model | MGI Sequence Detail 5229 C57BL/6J ±  kb
    transcript ENSMUST00000102574 Ensembl | MGI Sequence Detail 2168 Not Applicable  
    polypeptide ENSMUSP00000099634 Ensembl | MGI Sequence Detail 656 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000003604 very long-chain specific acyl-CoA dehydrogenase, mitochondrial
      (term hierarchy)
    • PDB
      8CA1
    • EC
      1.3.8.9
    • InterPro Domains
      IPR049448 ACAD9/ACADV-like, C-terminal domain
      IPR006089 Acyl-CoA dehydrogenase, conserved site
      IPR036250 Acyl-CoA dehydrogenase-like, C-terminal
      IPR009075 Acyl-CoA dehydrogenase/oxidase, C-terminal
      IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
      IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
      IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
      IPR006091 Acyl-CoA oxidase/dehydrogenase, middle domain
      IPR046373 Acyl-CoA oxidase/dehydrogenase, middle domain superfamily
    • GlyGen
      P50544 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 278
      Genomic 4
      cDNA 271
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 11
      Diseases 4
      Gene Ontology 10
      Phenotypes 51
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory