Dcaf11 MGI Mouse Gene Detail - MGI:90168 - DDB1 and CUL4 associated factor 11

Symbol

Dcaf11
Name

DDB1 and CUL4 associated factor 11
Synonyms

0710008A13Rik, D14Ucla1, GLO14, Wdr23

Feature Type

protein coding gene
IDs

MGI:90168
NCBI Gene: 28199
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr14:55797463-55807522 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.19 cM
Mapping Data

4 experiments

SNPs within 2kb

252 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_90168	protein coding gene	Chr14:55796557-55807522 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021349	protein coding gene	Chr14:49593338-49603397 (+)
A/J	MGP_AJ_G0021308	protein coding gene	Chr14:48606162-48616221 (+)
AKR/J	MGP_AKRJ_G0021284	protein coding gene	Chr14:50352505-50362564 (+)
BALB/cJ	MGP_BALBcJ_G0021312	protein coding gene	Chr14:48552855-48562914 (+)
C3H/HeJ	MGP_C3HHeJ_G0021092	protein coding gene	Chr14:50039107-50049166 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021750	protein coding gene	Chr14:52087339-52097398 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019297	protein coding gene	Chr14:46979426-46989471 (+)
CAST/EiJ	MGP_CASTEiJ_G0020611	protein coding gene	Chr14:46302566-46312575 (+)
CBA/J	MGP_CBAJ_G0021059	protein coding gene	Chr14:53644853-53654912 (+)
DBA/2J	MGP_DBA2J_G0021180	protein coding gene	Chr14:48332050-48342109 (+)
FVB/NJ	MGP_FVBNJ_G0021162	protein coding gene	Chr14:47781048-47791118 (+)
LP/J	MGP_LPJ_G0021254	protein coding gene	Chr14:50639553-50649612 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021186	protein coding gene	Chr14:53004369-53014439 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021777	protein coding gene	Chr14:49539950-49550009 (+)
PWK/PhJ	MGP_PWKPhJ_G0020358	protein coding gene	Chr14:44862372-44872431 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020186	protein coding gene	Chr14:45537819-45547830 (+)
WSB/EiJ	MGP_WSBEiJ_G0020664	protein coding gene	Chr14:49823366-49833437 (+)

Human Ortholog

DCAF11, DDB1 and CUL4 associated factor 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DCAF11, DDB1 and CUL4 associated factor 11
Synonyms

GL014, PRO2389, WDR23
Links

HGNC:20258

NCBI Gene ID: 80344

neXtProt AC: NX_Q8TEB1

UniProt: Q8TEB1
Chr Location

14q12; chr14:24114195-24125242 (+) GRCh38

MGI Vertebrate Homology

Dcaf11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DCAF11
Protein SuperFamily

WD_repeat_p23
Gene Tree

Dcaf11

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Phenotype Summary

18 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Targeted

6
Genomic Mutations

1 involving Dcaf11
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Null mice show gradual telomere erosion with successive generations and compromised hematopoietic stem cell activity. Homozygotes for another null allele show changes in multiple age-related hippocampal-dependent behaviors and males show reduced insulin levels and impaired insulin sensitivity.

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All GO Annotations

16
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

6
cDNA Data

11
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dcaf11

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All Sequences

127
RefSeq

45
UniProt

10
CCDS

CCDS27115.1

Ensembl

ENSMUSG00000022214 (Evidence)
NCBI Gene

28199

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022214	Ensembl Gene Model \| MGI Sequence Detail	10060	C57BL/6J	± kb
transcript	ENSMUST00000121622	Ensembl \| MGI Sequence Detail	2379	Not Applicable
polypeptide	ENSMUSP00000113202	Ensembl \| MGI Sequence Detail	549	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000031241 DDB1- and CUL4-associated factor 11

(term hierarchy)
InterPro Domains

IPR051859 DDB1- and CUL4-associated factor

IPR020472 G-protein beta WD-40 repeat

IPR001680 WD40 repeat

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

IPR017399 WD repeat protein DCAF11/LEC14B

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All nucleic 14

cDNA 12

Primer pair 1

Other 1

Microarray probesets 4

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MGD-MRK-3966, MGI:1918950, MGI:2145858

Summaries

All 48

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 16
Earliest

J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
Latest

J:351189 Duangjan C, et al., Hepatic WDR23 proteostasis mediates insulin homeostasis by regulating insulin-degrading enzyme capacity. Geroscience. 2024 May 20;

TSS for Dcaf11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125767	Chr14:55797450-55797461 (+)	-7 bp
Tssr125768	Chr14:55797467-55797494 (+)	18 bp
Tssr125769	Chr14:55797937-55797985 (+)	498 bp
Tssr125770	Chr14:55798361-55798431 (+)	933 bp
Tssr125771	Chr14:55798504-55798513 (+)	1,046 bp
Tssr125772	Chr14:55798517-55798528 (+)	1,060 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24