Dhrs4 MGI Mouse Gene Detail - MGI:90169 - dehydrogenase/reductase 4

Symbol

Dhrs4
Name

dehydrogenase/reductase 4
Synonyms

D14Ucla2, dehydrogenase/reductase (SDR family) member 4, RRD

Feature Type

protein coding gene
IDs

MGI:90169
NCBI Gene: 28200
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr14:55716215-55727797 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.19 cM
Mapping Data

4 experiments

SNPs within 2kb

307 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_90169	protein coding gene	Chr14:55715880-55727797 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021343	protein coding gene	Chr14:49506961-49518293 (+)
A/J	MGP_AJ_G0021302	protein coding gene	Chr14:48522439-48535632 (+)
AKR/J	MGP_AKRJ_G0021278	protein coding gene	Chr14:50271592-50282392 (+)
BALB/cJ	MGP_BALBcJ_G0021306	protein coding gene	Chr14:48469865-48480958 (+)
C3H/HeJ	MGP_C3HHeJ_G0021086	protein coding gene	Chr14:49954408-49966931 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021744	protein coding gene	Chr14:51995327-52010180 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019291	protein coding gene	Chr14:46902112-46912432 (+)
CAST/EiJ	MGP_CASTEiJ_G0020605	protein coding gene	Chr14:46215123-46226970 (+)
CBA/J	MGP_CBAJ_G0021053	protein coding gene	Chr14:53555344-53569112 (+)
DBA/2J	MGP_DBA2J_G0021174	protein coding gene	Chr14:48244183-48255798 (+)
FVB/NJ	MGP_FVBNJ_G0021156	protein coding gene	Chr14:47700629-47711035 (+)
LP/J	MGP_LPJ_G0021248	protein coding gene	Chr14:50546902-50558961 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021180	protein coding gene	Chr14:52919684-52931191 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021771	protein coding gene	Chr14:49451974-49465821 (+)
PWK/PhJ	MGP_PWKPhJ_G0020352	protein coding gene	Chr14:44778688-44790761 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020180	protein coding gene	Chr14:45446478-45456588 (+)
WSB/EiJ	MGP_WSBEiJ_G0020658	protein coding gene	Chr14:49736878-49747327 (+)

Human Ortholog

DHRS4, dehydrogenase/reductase 4

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DHRS4, dehydrogenase/reductase 4
Synonyms

CR, NRDR, PHCR, PSCD, SCAD-SRL, SDR25C1, SDR25C2, SDR-SRL
Links

HGNC:16985

NCBI Gene ID: 10901

neXtProt AC: NX_Q9BTZ2

UniProt: Q9BTZ2
Chr Location

14q11.2; chr14:23953734-23969279 (+) GRCh38

Human Ortholog

DHRS4L1, dehydrogenase/reductase 4 like 1 (pseudogene)
Synonyms

SDR25C4
Links

HGNC:19732

NCBI Gene ID: 728635

UniProt: P0CG22
Chr Location

14q11.2

Human Ortholog

DHRS4L2, dehydrogenase/reductase 4 like 2
Synonyms

SDR25C3
Links

HGNC:19731

NCBI Gene ID: 317749

neXtProt AC: NX_Q6PKH6

UniProt: Q6PKH6
Chr Location

14q11.2; chr14:23969874-24006408 (+) GRCh38

MGI Vertebrate Homology

Dhrs4 stringent orthology
3 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DHRS4, DHRS4L1, DHRS4L2
Gene Tree

Dhrs4

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Targeted

5
Genomic Mutations

1 involving Dhrs4
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice exhibit a decreased mean serum IgG2a response to ovalbumin challenge when compared with that of controls. Female mutants exhibit an increased depressive-like response during tail suspension testing.

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All GO Annotations

23
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

99

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dhrs4

ZFIN dhrs4

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All Sequences

63
RefSeq

6
UniProt

8
CCDS

CCDS27111.1, CCDS88668.1

Ensembl

ENSMUSG00000022210 (Evidence)
NCBI Gene

28200

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022210	Ensembl Gene Model \| MGI Sequence Detail	11583	C57BL/6J	± kb
transcript	ENSMUST00000022821	Ensembl \| MGI Sequence Detail	1392	Not Applicable
polypeptide	ENSMUSP00000022821	Ensembl \| MGI Sequence Detail	279	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000006466 dehydrogenase/reductase SDR family member 4

(term hierarchy)
EC

1.1.1.184, 1.1.1.300
InterPro Domains

IPR036291 NAD(P)-binding domain superfamily

IPR020904 Short-chain dehydrogenase/reductase, conserved site

IPR002347 Short-chain dehydrogenase/reductase SDR
GlyGen

Q99LB2 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 100

cDNA 99

Other 1

Microarray probesets 4

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MGD-MRK-3967, MGI:2145595, MGI:2145693

Summaries

All 46

Gene Ontology 9

Phenotypes 12
Earliest

J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dhrs4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125755	Chr14:55716210-55716224 (+)	2 bp
Tssr125756	Chr14:55716227-55716252 (+)	25 bp
Tssr125757	Chr14:55716259-55716264 (+)	47 bp
Tssr125758	Chr14:55716272-55716277 (+)	60 bp
Tssr125759	Chr14:55716324-55716371 (+)	133 bp
Tssr125760	Chr14:55716381-55716398 (+)	175 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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