Lrrc32 MGI Mouse Gene Detail - MGI:93882 - leucine rich repeat containing 32

Symbol

Lrrc32
Name

leucine rich repeat containing 32
Synonyms

D11S833Eh, D7H11S833E, EG434215, Garp

Feature Type

protein coding gene
IDs

MGI:93882
NCBI Gene: 434215
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:98138515-98151038 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 53.86 cM, cytoband E1-F2
Mapping Data

3 experiments

SNPs within 2kb

436 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_93882	protein coding gene	Chr7:98138490-98151388 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032540	protein coding gene	Chr7:101219695-101232604 (+)
A/J	MGP_AJ_G0032514	protein coding gene	Chr7:98723114-98736028 (+)
AKR/J	MGP_AKRJ_G0032450	protein coding gene	Chr7:101068327-101081242 (+)
BALB/cJ	MGP_BALBcJ_G0032525	protein coding gene	Chr7:98411059-98424427 (+)
C3H/HeJ	MGP_C3HHeJ_G0032240	protein coding gene	Chr7:101423670-101436578 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033023	protein coding gene	Chr7:105139714-105152623 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030018	protein coding gene	Chr7:101159040-101171891 (+)
CAST/EiJ	MGP_CASTEiJ_G0031567	protein coding gene	Chr7:92942603-92955518 (+)
CBA/J	MGP_CBAJ_G0032207	protein coding gene	Chr7:108729674-108742582 (+)
DBA/2J	MGP_DBA2J_G0032359	protein coding gene	Chr7:97057359-97070267 (+)
FVB/NJ	MGP_FVBNJ_G0032316	protein coding gene	Chr7:96855901-96868808 (+)
LP/J	MGP_LPJ_G0032448	protein coding gene	Chr7:102549872-102562790 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032348	protein coding gene	Chr7:110245518-110259227 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033045	protein coding gene	Chr7:100335466-100348371 (+)
PWK/PhJ	MGP_PWKPhJ_G0031285	protein coding gene	Chr7:90138984-90151897 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031128	protein coding gene	Chr7:87621386-87641087 (+)
WSB/EiJ	MGP_WSBEiJ_G0031684	protein coding gene	Chr7:100996770-101009685 (+)

Human Ortholog

LRRC32, leucine rich repeat containing 32

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRRC32, leucine rich repeat containing 32
Synonyms

CPPRDD, D11S833E, GARP
Links

HGNC:4161

NCBI Gene ID: 2615

neXtProt AC: NX_Q14392

UniProt: Q14392
Chr Location

11q13.5; chr11:76657524-76670747 (-) GRCh38

MGI Vertebrate Homology

Lrrc32 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LRRC32
Gene Tree

Lrrc32

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

1
Targeted

4
Transgenic

1
Genomic Mutations

2 involving Lrrc32
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit complete neonatal lethality and defective secondary palate development with no apparent abnormalities in other major organs.

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All GO Annotations

22
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

765
Tissues

46
cDNA Data

13
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lrrc32

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All Sequences

35
RefSeq

6
UniProt

2
CCDS

CCDS52319.1

Ensembl

ENSMUSG00000090958 (Evidence)
NCBI Gene

434215

			Length	Strain/Species	Flank
genomic	434215	NCBI Gene Model \| MGI Sequence Detail	12524	C57BL/6J	± kb
transcript	NM_001113379	RefSeq \| MGI Sequence Detail	3932	ZRU/MplStud
polypeptide	G3XA59	UniProt \| EBI \| MGI Sequence Detail	663	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031149 transforming growth factor beta activator LRRC32

(term hierarchy)
InterPro Domains

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR050333 Small Leucine-Rich Proteoglycans
GlyGen

G3XA59 6 sites, 2 N-linked glycans (2 sites)

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All nucleic 16

Genomic 1

cDNA 13

Primer pair 1

Other 1

Microarray probesets 1

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MGD-MRK-3048, MGD-MRK-7790, MGD-MRK-9983, MGI:2141939, MGI:3647721

Summaries

All 50

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 22
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:306327 Xu J, et al., Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene Expression in Palate Development. Front Cell Dev Biol. 2021;9:665109

TSS for Lrrc32:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68015	Chr7:98139190-98139208 (+)	684 bp
Tssr68016	Chr7:98139235-98139246 (+)	726 bp
Tssr68017	Chr7:98139764-98139803 (+)	1,269 bp
Tssr68018	Chr7:98141156-98141168 (+)	2,647 bp
Tssr68019	Chr7:98141177-98141205 (+)	2,676 bp
Tssr68020	Chr7:98150112-98150116 (+)	11,599 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24