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Ppp1r1b Gene Detail
Summary
  • Symbol
    Ppp1r1b
  • Name
    protein phosphatase 1, regulatory inhibitor subunit 1B
  • Synonyms
    Darpp32, DARPP-32
  • Feature Type
    protein coding gene
  • IDs
    MGI:94860
    NCBI Gene: 19049
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98239232-98248622 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 61.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    243 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94860
 protein coding gene Chr11:98239230-98248622 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019054
 protein coding gene Chr11:100884728-100895583 (+)
A/J MGP_AJ_G0019022
 protein coding gene Chr11:96695776-96704484 (+)
AKR/J MGP_AKRJ_G0018992
 protein coding gene Chr11:99686778-99695490 (+)
BALB/cJ MGP_BALBcJ_G0018995
 protein coding gene Chr11:97186286-97194999 (+)
C3H/HeJ MGP_C3HHeJ_G0018809
 protein coding gene Chr11:99823042-99831759 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019448
 protein coding gene Chr11:103960579-103969301 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017079
 protein coding gene Chr11:94135185-94143909 (+)
CAST/EiJ MGP_CASTEiJ_G0018363
 protein coding gene Chr11:100698007-100706873 (+)
CBA/J MGP_CBAJ_G0018780
 protein coding gene Chr11:108279098-108287812 (+)
DBA/2J MGP_DBA2J_G0018888
 protein coding gene Chr11:96237318-96246038 (+)
FVB/NJ MGP_FVBNJ_G0018877
 protein coding gene Chr11:95745470-95754179 (+)
LP/J MGP_LPJ_G0018958
 protein coding gene Chr11:101366049-101374768 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018904
 protein coding gene Chr11:108078567-108087304 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019488
 protein coding gene Chr11:100018373-100027732 (+)
PWK/PhJ MGP_PWKPhJ_G0018135
 protein coding gene Chr11:97242887-97253223 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017925
 protein coding gene Chr11:99724375-99733029 (+)
WSB/EiJ MGP_WSBEiJ_G0018413
 protein coding gene Chr11:99926233-99937994 (+)



Homology
more
  • Human Ortholog
    PPP1R1B, protein phosphatase 1 regulatory inhibitor subunit 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP1R1B, protein phosphatase 1 regulatory inhibitor subunit 1B
  • Synonyms
    DARPP-32, DARPP32
  • Links
    NCBI Gene ID: 84152
    neXtProt AC: NX_Q9UD71
    UniProt: Q9UD71

  • Chr Location
    17q12; chr17:39626707-39636626 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PPP1R1B associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 6 alleles in 6 genetic backgrounds
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit elevated substance P-like immunoreactivity and deficits in responses to dopamine, cocaine, ethanol, and antipsychotic drugs. Abnormalities in striatal function were also noted.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    36
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    852
  • Tissues
    65
  • cDNA Data
    83
  • Literature Summary
    84
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19049 NCBI Gene Model | MGI Sequence Detail 9391 C57BL/6J ±  kb
transcript NM_144828 RefSeq | MGI Sequence Detail 2017 C57BL/6  
polypeptide Q60829 UniProt | EBI | MGI Sequence Detail 194 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013121 protein phosphatase 1 regulatory subunit 1B
    (term hierarchy)
  • InterPro Domains
    IPR008466 Protein phosphatase inhibitor 1
  • GlyGen
    Q60829 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 86
    Genomic 2
    cDNA 83
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-8796, MGI:2144421
References
more
  • Summaries
    All 177
    Developmental Gene Expression 84
    Gene Ontology 12
    Phenotypes 54
  • Earliest
    J:49 Perez RG, et al., Regional distribution of DARPP-32 (dopamine- and adenosine 3',5'-monophosphate-regulated phosphoprotein of Mr = 32,000) mRNA in mouse brain. J Comp Neurol. 1992 Apr 15;318(3):304-15
  • Latest
    J:339946 Galazo MJ, et al., Tle4 controls both developmental acquisition and early post-natal maturation of corticothalamic projection neuron identity. Cell Rep. 2023 Aug 29;42(8):112957
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory