Dbf Gene Detail

Summary

• Symbol
  Dbf
• Name
  doublefoot

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:94863
  NCBI Gene: 109578
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr1:59938031-82944074 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, Syntenic
• Mapping Data
  7 experiments

Human Diseases

• Diseases
  1 with Dbf mouse models

Human Disease

Mouse Models

clubfoot

IDs

clubfoot      

DOID:11836
DOID:0001874
ICD10CM:Q66.89
ICD9CM:754.51
MESH:D003025
NCI:C84641
OMIM:119800
UMLS_CUI:C0009081

View 1 model

Mouse Models

Human Disease Modeled: clubfoot

Allelic Composition	Genetic Background	Reference	Phenotypes
Dbf/Dbf+	involves: 101/H * C3H/HeH	J:39106	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  60 phenotypes from 1 allele in 2 genetic backgrounds
  10 phenotype references
  

• All Mutations and Alleles
  1
• Spontaneous
  1
• Find Mice (IMSR)
  2 strains or lines available

Homozygous mutants die late in emrbyonic development with split face, bulged heads and edema; heterozygotes have severe limb defects with duplicate toes on all feet, hindlimb shortening, broad skulls, clubbed feet, and reduced viability and fertility.

Sequences &
Gene Models

• NCBI Gene
  109578

Other
Accession IDs

MGD-MRK-8800

References

• Summaries
  All 12

  Diseases 1

  Phenotypes 10
• Earliest
  J:34785 Christner PJ, et al., A high-resolution linkage map of the tight skin 2 (Tsk2) locus: a mouse model for scleroderma (SSc) and other cutaneous fibrotic diseases. Mamm Genome. 1996 Aug;7(8):610-2
• Latest
  J:135300 Babbs C, et al., Polydactyly in the mouse mutant Doublefoot involves altered Gli3 processing and is caused by a large deletion in cis to Indian hedgehog. Mech Dev. 2008 May-Jun;125(5-6):517-26