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Dbh Gene Detail
Summary
  • Symbol
    Dbh
  • Name
    dopamine beta hydroxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:94864
    NCBI Gene: 13166
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:27055519-27073216 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 19.29 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    541 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94864
 protein coding gene Chr2:27055245-27073216 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025511
 protein coding gene Chr2:25138131-25158943 (+)
A/J MGP_AJ_G0025488
 protein coding gene Chr2:24190035-24209107 (+)
AKR/J MGP_AKRJ_G0025458
 protein coding gene Chr2:24983482-25003611 (+)
BALB/cJ MGP_BALBcJ_G0025484
 protein coding gene Chr2:24308908-24327398 (+)
C3H/HeJ MGP_C3HHeJ_G0025245
 protein coding gene Chr2:24918989-24937637 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025928
 protein coding gene Chr2:25990076-26009731 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023339
 protein coding gene Chr2:23024108-23042255 (+)
CAST/EiJ MGP_CASTEiJ_G0024708
 protein coding gene Chr2:24800398-24818302 (+)
CBA/J MGP_CBAJ_G0025223
 protein coding gene Chr2:26895094-26915211 (+)
DBA/2J MGP_DBA2J_G0025356
 protein coding gene Chr2:24011996-24030577 (+)
FVB/NJ MGP_FVBNJ_G0025318
 protein coding gene Chr2:23769392-23787650 (+)
LP/J MGP_LPJ_G0025442
 protein coding gene Chr2:25082457-25100072 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025349
 protein coding gene Chr2:26932510-26952412 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025987
 protein coding gene Chr2:24919431-24937326 (+)
PWK/PhJ MGP_PWKPhJ_G0024456
 protein coding gene Chr2:23800963-23821307 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024256
 protein coding gene Chr2:25062669-25081062 (+)
WSB/EiJ MGP_WSBEiJ_G0024777
 protein coding gene Chr2:25034470-25053680 (+)



Homology
more
  • Human Ortholog
    DBH, dopamine beta-hydroxylase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DBH, dopamine beta-hydroxylase
  • Synonyms
    DBM, ORTHYP1
  • Links
    NCBI Gene ID: 1621
    neXtProt AC: NX_P09172
    UniProt: P09172

  • Chr Location
    9q34.2; chr9:133636363-133659329 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dbh mouse models; 6 with human DBH associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 3 alleles in 4 genetic backgrounds
    41 phenotypes from multigenic genotypes
    126 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants are embryonic lethal probably due to cardiovascular failure, but survive if treated to replace their dopamine deficit.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    951
  • Tissues
    150
  • cDNA Data
    14
  • Literature Summary
    76
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13166 NCBI Gene Model | MGI Sequence Detail 17698 C57BL/6J ±  kb
    transcript NM_138942 RefSeq | MGI Sequence Detail 2282 ZRU/MplStud  
    polypeptide Q64237 UniProt | EBI | MGI Sequence Detail 622 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000006294 dopamine beta-hydroxylase
      (term hierarchy)
    • PDB
      6G9Q, 6G9R
    • EC
      1.14.17.1
    • InterPro Domains
      IPR045266 Copper-dependent monooxygenases, DOMON domain
      IPR024548 Copper type II ascorbate-dependent monooxygenase, C-terminal
      IPR020611 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site
      IPR014783 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site
      IPR014784 Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
      IPR000323 Copper type II, ascorbate-dependent monooxygenase, N-terminal
      IPR036939 Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily
      IPR005018 DOMON domain
      IPR000945 Dopamine beta-hydroxylase-like
      IPR008977 PHM/PNGase F domain superfamily
      IPR028460 Tyramine beta-hydroxylase/Dopamine beta-hydroxylase
    • GlyGen
      Q64237 4 sites, 3 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 7
      cDNA 15
      Primer pair 6
      Other 10

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-8801
    References
    more
    • Summaries
      All 244
      Developmental Gene Expression 76
      Diseases 1
      Gene Ontology 23
      Phenotypes 126
    • Earliest
      J:331 Pilz A, et al., Comparative mapping of mouse chromosome 2 and human chromosome 9q: the genes for gelsolin and dopamine beta-hydroxylase map to mouse chromosome 2. Genomics. 1992 Apr;12(4):715-9
    • Latest
      J:359095 Chang Y, et al., Vglut2-based glutamatergic signaling in central noradrenergic neurons is dispensable for normal breathing and chemosensory reflexes. Elife. 2024 Sep 17;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory