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Dbx1 Gene Detail
Summary
  • Symbol
    Dbx1
  • Name
    developing brain homeobox 1
  • Synonyms
    Dbx, Mmox C
  • Feature Type
    protein coding gene
  • IDs
    MGI:94867
    NCBI Gene: 13172
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:49281247-49286583 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 31.44 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    211 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94867
 protein coding gene Chr7:49281247-49286597 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032298
 protein coding gene Chr7:50292574-50297889 (-)
A/J MGP_AJ_G0032277
 protein coding gene Chr7:49546622-49551964 (-)
AKR/J MGP_AKRJ_G0032213
 protein coding gene Chr7:50726932-50732283 (-)
BALB/cJ MGP_BALBcJ_G0032289
 protein coding gene Chr7:49201510-49206845 (-)
C3H/HeJ MGP_C3HHeJ_G0032002
 protein coding gene Chr7:51097318-51102645 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032782
 protein coding gene Chr7:52602304-52607638 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029788
 protein coding gene Chr7:52719242-52724524 (-)
CAST/EiJ MGP_CASTEiJ_G0031330
 protein coding gene Chr7:42507191-42512509 (-)
CBA/J MGP_CBAJ_G0031967
 protein coding gene Chr7:54360582-54365925 (-)
DBA/2J MGP_DBA2J_G0032124
 protein coding gene Chr7:48771947-48777279 (-)
FVB/NJ MGP_FVBNJ_G0032078
 protein coding gene Chr7:48701265-48707188 (-)
LP/J MGP_LPJ_G0032205
 protein coding gene Chr7:51245744-51251067 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032115
 protein coding gene Chr7:53486287-53491623 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032799
 protein coding gene Chr7:49709894-49715218 (-)
PWK/PhJ MGP_PWKPhJ_G0031050
 protein coding gene Chr7:42113527-42118977 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030891
 protein coding gene Chr7:37884912-37890206 (-)
WSB/EiJ MGP_WSBEiJ_G0031448
 protein coding gene Chr7:50368667-50373985 (-)



Homology
more
  • Human Ortholog
    DBX1, developing brain homeobox 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DBX1, developing brain homeobox 1
  • Synonyms
    HLX1
  • Links
    NCBI Gene ID: 120237
    neXtProt AC: NX_A6NMT0
    UniProt: A6NMT0

  • Chr Location
    11p15.1; chr11:20156155-20160475 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    93 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene die at birth. V0 interneurons develop as V1 or dl6 interneurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1106
  • Tissues
    176
  • cDNA Data
    16
  • Literature Summary
    166
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13172 NCBI Gene Model | MGI Sequence Detail 5337 C57BL/6J ±  kb
    transcript NM_001005232 RefSeq | MGI Sequence Detail 2096 ZRU/MplStud  
    polypeptide P52950 UniProt | EBI | MGI Sequence Detail 335 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 5
      cDNA 18
      Primer pair 2
      Other 15

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-8806, MGI:2141937
    References
    more
    • Summaries
      All 255
      Developmental Gene Expression 166
      Gene Ontology 6
      Phenotypes 93
    • Earliest
      J:2276 Murtha MT, et al., Detection of homeobox genes in development and evolution. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10711-5
    • Latest
      J:358820 Dudukcu O, et al., Molecular diversity and migration of GABAergic neurons in the developing ventral midbrain. iScience. 2024 Nov 15;27(11):111239
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory