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Eci1 Gene Detail
Summary
  • Symbol
    Eci1
  • Name
    enoyl-Coenzyme A delta isomerase 1
  • Synonyms
    Dci, eci
  • Feature Type
    protein coding gene
  • IDs
    MGI:94871
    NCBI Gene: 13177
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24645657-24658290 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.39 cM, cytoband A3.3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    485 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94871
 protein coding gene Chr17:24645615-24658322 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023298
 protein coding gene Chr17:23407467-23422650 (+)
A/J MGP_AJ_G0023258
 protein coding gene Chr17:22780034-22795723 (+)
AKR/J MGP_AKRJ_G0023225
 protein coding gene Chr17:22854359-22868958 (+)
BALB/cJ MGP_BALBcJ_G0023263
 protein coding gene Chr17:22962375-22976552 (+)
C3H/HeJ MGP_C3HHeJ_G0023023
 protein coding gene Chr17:23205922-23221906 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023707
 protein coding gene Chr17:24451823-24467373 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021183
 protein coding gene Chr17:20245906-20261192 (+)
CAST/EiJ MGP_CASTEiJ_G0022525
 protein coding gene Chr17:23042250-23056008 (+)
CBA/J MGP_CBAJ_G0022999
 protein coding gene Chr17:25283911-25300141 (+)
DBA/2J MGP_DBA2J_G0023128
 protein coding gene Chr17:22363336-22379269 (+)
FVB/NJ MGP_FVBNJ_G0023098
 protein coding gene Chr17:22082047-22096022 (+)
LP/J MGP_LPJ_G0023205
 protein coding gene Chr17:23715496-23733158 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023117
 protein coding gene Chr17:24998875-25013589 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023744
 protein coding gene Chr17:23132855-23146818 (+)
PWK/PhJ MGP_PWKPhJ_G0022274
 protein coding gene Chr17:21118644-21132080 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022093
 protein coding gene Chr17:21159279-21178331 (+)
WSB/EiJ MGP_WSBEiJ_G0022588
 protein coding gene Chr17:23196733-23213529 (+)



Homology
more
  • Human Ortholog
    ECI1, enoyl-CoA delta isomerase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ECI1, enoyl-CoA delta isomerase 1
  • Synonyms
    DCI
  • Links
    NCBI Gene ID: 1632
    neXtProt AC: NX_P42126
    UniProt: P42126

  • Chr Location
    16p13.3; chr16:2239402-2252300 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene are normal until stressed. Starvation results in increased accumulation of triglycerides and unsaturated fatty acids in the liver and kidney. Secretion of fatty acid metabolites in the urine is greatly increased.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    802
  • Tissues
    96
  • cDNA Data
    83
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13177 NCBI Gene Model | MGI Sequence Detail 12634 C57BL/6J ±  kb
    transcript NM_010023 RefSeq | MGI Sequence Detail 1091 Not Specified  
    polypeptide P42125 UniProt | EBI | MGI Sequence Detail 289 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      Genomic 2
      cDNA 84
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-8810
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 7
    • Earliest
      J:15191 Stoffel W, et al., Molecular cloning and gene organization of the mouse mitochondrial 3,2-trans-enoyl-CoA isomerase. FEBS Lett. 1993 Oct 25;333(1-2):119-22
    • Latest
      J:302181 Xu Y, et al., Etomoxir regulates the differentiation of male germ cells by specifically reducing H3K27ac level. BMC Dev Biol. 2021 Feb 1;21(1):5
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory