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Defa29 Gene Detail
Summary
  • Symbol
    Defa29
  • Name
    defensin, alpha, 29
  • Synonyms
    2010300L12Rik, 2010319H24Rik, CRS1C-2, Defa-rs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:94881
    NCBI Gene: 13218
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:21815904-21817034 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 10.35 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    100 from dbSNP Build 142
  • Strain Annotations
    10
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94881
 protein coding gene Chr8:21815903-21817036 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033427
 protein coding gene Chr8:19091455-19092601 (-)
A/J MGP_AJ_G0033407
 protein coding gene Chr8:18884602-18887258 (-)
AKR/J MGP_AKRJ_G0033335
 protein coding gene Chr8:18884135-19023853 (-)
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0033921
 protein coding gene Chr8:19547524-19843967 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030882
 protein coding gene Chr8:15504475-15505539 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0033091
 protein coding gene Chr8:20724399-20727113 (-)
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0033235
 protein coding gene Chr8:20782211-20783343 (-)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0032155
 protein coding gene Chr8:18160981-18162112 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0032559
 protein coding gene Chr8:19145368-19146498 (-)



Homology
more
  • Human Ortholog
    DEFA3, defensin alpha 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFA3, defensin alpha 3
  • Synonyms
    DEF3, HNP-3, HNP3, HP-3, HP3
  • Links
    NCBI Gene ID: 1668
    neXtProt AC: NX_P59666
    UniProt: P59666

  • Chr Location
    8p23.1; chr8:7015869-7018297 (-)  GRCh38
  • Human Ortholog
    DEFA6, defensin alpha 6
  • Synonyms
    DEF6, HD-6
  • Links
    NCBI Gene ID: 1671
    neXtProt AC: NX_Q01524
    UniProt: Q01524

  • Chr Location
    8p23.1; chr8:6924697-6926076 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    3
  • cDNA Data
    6
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 13218 NCBI Gene Model | MGI Sequence Detail 1131 C57BL/6J ±  kb
transcript NM_007844 RefSeq | MGI Sequence Detail 505 ZRU/MplStud  
polypeptide P17533 UniProt | EBI | MGI Sequence Detail 116 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-8825, MGI:1915258, MGI:2156648
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 2
  • Earliest
    J:10551 Ouellette AJ, et al., A novel mouse gene family coding for cationic, cysteine-rich peptides. Regulation in small intestine and cells of myeloid origin [published erratum appears in J Biol Chem 1994 Jul 15;269(28):18702]. J Biol Chem. 1990 Jun 15;265(17):9831-7
  • Latest
    J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory