Dlx3 MGI Mouse Gene Detail - MGI:94903

Symbol

Dlx3
Name

distal-less homeobox 3
Synonyms

Dlx-3

Feature Type

protein coding gene
IDs

MGI:94903
NCBI Gene: 13393
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:95010945-95016122 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 59.01 cM
Mapping Data

3 experiments

SNPs within 2kb

156 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_94903	protein coding gene	Chr11:95010943-95016122 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018977	protein coding gene	Chr11:97306619-97311796 (+)
A/J	MGP_AJ_G0018945	protein coding gene	Chr11:93379546-93384720 (+)
AKR/J	MGP_AKRJ_G0018915	protein coding gene	Chr11:96269012-96274186 (+)
BALB/cJ	MGP_BALBcJ_G0018918	protein coding gene	Chr11:93851411-93856582 (+)
C3H/HeJ	MGP_C3HHeJ_G0018732	protein coding gene	Chr11:96393653-96398826 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019370	protein coding gene	Chr11:100370527-100375702 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017001	protein coding gene	Chr11:90865693-90870858 (+)
CAST/EiJ	MGP_CASTEiJ_G0018286	protein coding gene	Chr11:97192572-97200819 (+)
CBA/J	MGP_CBAJ_G0018703	protein coding gene	Chr11:104472718-104477892 (+)
DBA/2J	MGP_DBA2J_G0018811	protein coding gene	Chr11:92954538-92959713 (+)
FVB/NJ	MGP_FVBNJ_G0018800	protein coding gene	Chr11:92417730-92422907 (+)
LP/J	MGP_LPJ_G0018881	protein coding gene	Chr11:97874851-97880028 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018827	protein coding gene	Chr11:104521563-104526716 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019410	protein coding gene	Chr11:96530998-96536179 (+)
PWK/PhJ	MGP_PWKPhJ_G0018057	protein coding gene	Chr11:93871352-93879827 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017846	protein coding gene	Chr11:96215474-96220654 (+)
WSB/EiJ	MGP_WSBEiJ_G0018335	protein coding gene	Chr11:96452319-96457489 (+)

Human Ortholog

DLX3, distal-less homeobox 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DLX3, distal-less homeobox 3
Synonyms

AI4, TDO
Links

HGNC:2916

NCBI Gene ID: 1747

neXtProt AC: NX_O60479

UniProt: O60479
Chr Location

17q21.33; chr17:49990005-49995224 (-) GRCh38

MGI Vertebrate Homology

Dlx3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DLX3
Gene Tree

Dlx3

Diseases

2 with human DLX3 associations

				Human Disease	Mouse Models
				amelogenesis imperfecta type 4 IDs amelogenesis imperfecta type 4 DOID:0110053 ICD10CM:K00.5 OMIM:104510
				trichodontoosseous syndrome IDs trichodontoosseous syndrome DOID:0111565 MESH:C536549 OMIM:190320 ORDO:3352 UMLS_CUI:C0265333

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

29 phenotypes from 4 alleles in 4 genetic backgrounds
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

2
Gene trapped

1
Targeted

6
Genomic Mutations

2 involving Dlx3
Incidental Mutations

APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutants die at embryonic day 9.5-10.0 with defects in the labyrinthine trophoblast of the chorioallantoic placenta.

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All GO Annotations

37
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1294
Tissues

348
cDNA Data

22
Literature Summary

100

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA DLX3

Xenbase dlx3

ZFIN dlx3b

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All Sequences

34
RefSeq

2
UniProt

3
CCDS

CCDS25272.1

Ensembl

ENSMUSG00000001510 (Evidence)
NCBI Gene

13393

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001510	Ensembl Gene Model \| MGI Sequence Detail	5178	C57BL/6J	± kb
transcript	ENSMUST00000092768	Ensembl \| MGI Sequence Detail	2607	Not Applicable
polypeptide	ENSMUSP00000090443	Ensembl \| MGI Sequence Detail	287	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006529 homeobox protein DLX-3

(term hierarchy)
InterPro Domains

IPR050460 Distal-less homeobox transcription factors

IPR022135 Distal-less-like homeobox protein, N-terminal domain

IPR000047 Helix-turn-helix motif

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR020479 Homeobox domain, metazoa

IPR009057 Homeobox-like domain superfamily

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All nucleic 43

Genomic 3

cDNA 25

Primer pair 7

Other 8

Microarray probesets 4

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MGD-MRK-8859, MGD-MRK-8863, MGI:2144466

Summaries

All 161

Developmental Gene Expression 100

Gene Ontology 9

Phenotypes 25
Earliest

J:5719 Eicher EM, et al., Evolution of mammalian carbonic anhydrase loci by tanden duplication: close linkage of Car-1 and Car-2 to the centromere region of chromosome 3 of the mouse. Biochem Genet. 1976 Aug;14(7-8):651-60
Latest

J:353635 Lee DJ, et al., MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis. Exp Mol Med. 2024 Jul;56(7):1606-1619

TSS for Dlx3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104348	Chr11:95010646-95010659 (+)	-292 bp
Tssr104349	Chr11:95010936-95010951 (+)	-1 bp
Tssr104350	Chr11:95015813-95015818 (+)	4,871 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24