Dmwd MGI Mouse Gene Detail - MGI:94907 - dystrophia myotonica-containing WD repeat motif

Symbol

Dmwd
Name

dystrophia myotonica-containing WD repeat motif
Synonyms

59, Dm9, DMR-N9

Feature Type

protein coding gene
IDs

MGI:94907
NCBI Gene: 13401
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:18810152-18816701 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 9.46 cM
Mapping Data

4 experiments

SNPs within 2kb

195 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_94907	protein coding gene	Chr7:18810002-18816701 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031756	protein coding gene	Chr7:17027104-17035919 (+)
A/J	MGP_AJ_G0031732	protein coding gene	Chr7:16716487-16723031 (+)
AKR/J	MGP_AKRJ_G0031658	protein coding gene	Chr7:17175470-17182014 (+)
BALB/cJ	MGP_BALBcJ_G0031737	protein coding gene	Chr7:16909196-16916130 (+)
C3H/HeJ	MGP_C3HHeJ_G0031459	protein coding gene	Chr7:17434472-17441000 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032203	protein coding gene	Chr7:17919693-17926242 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029269	protein coding gene	Chr7:18364768-18371530 (+)
CAST/EiJ	MGP_CASTEiJ_G0030802	protein coding gene	Chr7:13835373-13843503 (+)
CBA/J	MGP_CBAJ_G0031421	protein coding gene	Chr7:18562990-18569539 (+)
DBA/2J	MGP_DBA2J_G0031576	protein coding gene	Chr7:16651847-16658706 (+)
FVB/NJ	MGP_FVBNJ_G0031528	protein coding gene	Chr7:16515663-16522622 (+)
LP/J	MGP_LPJ_G0031659	protein coding gene	Chr7:17372480-17379029 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031564	protein coding gene	Chr7:18431332-18437912 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032231	protein coding gene	Chr7:16780942-16788865 (+)
PWK/PhJ	MGP_PWKPhJ_G0030526	protein coding gene	Chr7:13740204-13746786 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030353	protein coding gene	Chr7:11465592-11472740 (+)
WSB/EiJ	MGP_WSBEiJ_G0030902	protein coding gene	Chr7:16981747-16990136 (+)

Human Ortholog

DMWD, DM1 locus, WD repeat containing

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DMWD, DM1 locus, WD repeat containing
Synonyms

D19S593E, DMR-N9, DMRN9, gene59
Links

HGNC:2936

NCBI Gene ID: 1762

neXtProt AC: NX_Q09019

UniProt: Q09019
Chr Location

19q13.32; chr19:45782947-45792845 (-) GRCh38

MGI Vertebrate Homology

Dmwd stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DMWD
Gene Tree

Dmwd

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Gene trapped

2
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available

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All GO Annotations

8
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

743
Tissues

34
cDNA Data

77
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

47
RefSeq

6
UniProt

4
CCDS

CCDS20888.2, CCDS90169.1

Ensembl

ENSMUSG00000030410 (Evidence)
NCBI Gene

13401

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030410	Ensembl Gene Model \| MGI Sequence Detail	6550	C57BL/6J	± kb
transcript	ENSMUST00000032570	Ensembl \| MGI Sequence Detail	2494	Not Applicable
polypeptide	ENSMUSP00000032570	Ensembl \| MGI Sequence Detail	665	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006551 dystrophia myotonica WD repeat-containing protein

(term hierarchy)
InterPro Domains

IPR001680 WD40 repeat

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

IPR051362 WD repeat creC family regulators

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All nucleic 83

Genomic 6

cDNA 77

Microarray probesets 3

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MGD-MRK-8867

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 8
Earliest

J:12705 Jansen G, et al., Characterization of the myotonic dystrophy region predicts multiple protein isoform-encoding mRNAs. Nat Genet. 1992 Jul;1(4):261-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dmwd:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr64774	Chr7:18809996-18810042 (+)	-133 bp
Tssr64775	Chr7:18810098-18810162 (+)	-22 bp
Tssr64776	Chr7:18810167-18810198 (+)	31 bp
Tssr64777	Chr7:18810326-18810334 (+)	178 bp
Tssr64778	Chr7:18814581-18814591 (+)	4,434 bp
Tssr64779	Chr7:18814631-18814648 (+)	4,488 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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