Drd4 MGI Mouse Gene Detail - MGI:94926

Symbol

Drd4
Name

dopamine receptor D4
Synonyms

D4R, Drd-4

Feature Type

protein coding gene
IDs

MGI:94926
NCBI Gene: 13491
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr7:140871931-140874868 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 86.60 cM
Mapping Data

6 experiments

SNPs within 2kb

162 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_94926	protein coding gene	Chr7:140871919-140876377 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033222	protein coding gene	Chr7:146474179-146477172 (+)
A/J	MGP_AJ_G0033204	protein coding gene	Chr7:142285160-142288153 (+)
AKR/J	MGP_AKRJ_G0033136	protein coding gene	Chr7:146214296-146217289 (+)
BALB/cJ	MGP_BALBcJ_G0033205	protein coding gene	Chr7:142030134-142033127 (+)
C3H/HeJ	MGP_C3HHeJ_G0032919	protein coding gene	Chr7:145972751-145975744 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033716	protein coding gene	Chr7:151827196-151830189 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030689	protein coding gene	Chr7:143495469-143498492 (+)
CAST/EiJ	MGP_CASTEiJ_G0032249	protein coding gene	Chr7:138270589-138273597 (+)
CBA/J	MGP_CBAJ_G0032891	protein coding gene	Chr7:156959426-156962407 (+)
DBA/2J	MGP_DBA2J_G0033043	protein coding gene	Chr7:140232531-140235512 (+)
FVB/NJ	MGP_FVBNJ_G0032996	protein coding gene	Chr7:140146196-140149189 (+)
LP/J	MGP_LPJ_G0033138	protein coding gene	Chr7:147971643-147974634 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033029	protein coding gene	Chr7:157619089-157622082 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033736	protein coding gene	Chr7:145187483-145190476 (+)
PWK/PhJ	MGP_PWKPhJ_G0031953	protein coding gene	Chr7:133512573-133515559 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031800	protein coding gene	Chr7:132009968-132012978 (+)
WSB/EiJ	MGP_WSBEiJ_G0032360	protein coding gene	Chr7:146132318-146136904 (+)

Human Ortholog

DRD4, dopamine receptor D4

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DRD4, dopamine receptor D4
Synonyms

D4DR
Links

HGNC:3025

NCBI Gene ID: 1815

neXtProt AC: NX_P21917

UniProt: P21917
Chr Location

11p15.5; chr11:637269-640706 (+) GRCh38

MGI Vertebrate Homology

Drd4 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: DRD4
Gene Tree

Drd4

Diseases

13 with human DRD4 associations

				Human Disease	Mouse Models
				alcohol use disorder IDs alcohol use disorder DOID:1574 ICD10CM:F10.1 ICD9CM:305.0 ICD9CM:305.00 MESH:D000437 NCI:C20701 UMLS_CUI:C0085762
				antisocial personality disorder IDs antisocial personality disorder DOID:10939 ICD10CM:F60.2 ICD9CM:301.7 MESH:D000987 NCI:C88413 UMLS_CUI:C0003431
				attention deficit hyperactivity disorder IDs attention deficit hyperactivity disorder DOID:1094 DOID:1093 EFO:0003888 ICD9CM:314.8 MESH:D001289 OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312 UMLS_CUI:C0041671
				cannabis abuse IDs cannabis abuse DOID:9505 DOID:2525 ICD10CM:F12 ICD10CM:F12.1 ICD9CM:305.2 MESH:D002189 UMLS_CUI:C0006868 UMLS_CUI:C0024809
				conduct disorder IDs conduct disorder DOID:12995 EFO:0004216 ICD10CM:F91 ICD9CM:312.9 MESH:D019955 NCI:C89329 UMLS_CUI:C0149654
				dyslexia IDs dyslexia DOID:4428 ICD10CM:F81.0 MESH:D004410 NCI:C96410 OMIM:300509 OMIM:600202 OMIM:604254 OMIM:606616 OMIM:606896 OMIM:608995 UMLS_CUI:C0476254
				Gilles de la Tourette syndrome IDs Gilles de la Tourette syndrome DOID:11119 EFO:0004895 ICD10CM:F95.2 ICD9CM:307.23 MESH:D005879 NCI:C35078 OMIM:137580 UMLS_CUI:C0040517
				heroin dependence IDs heroin dependence DOID:9976 MESH:D006556 NCI:C34694 UMLS_CUI:C0019337
				intellectual disability IDs intellectual disability DOID:1059 NCI:C84392 UMLS_CUI:C0025362
				liver cirrhosis IDs liver cirrhosis DOID:5082 EFO:0001422 ICD10CM:K74.60 MESH:D008103 NCI:C2951 UMLS_CUI:C0023890
				opioid abuse IDs opioid abuse DOID:11206 ICD10CM:F11.1 ICD9CM:305.5 MESH:D009293 UMLS_CUI:C0029095
				pathological gambling IDs pathological gambling DOID:12399 ICD10CM:F63.0 ICD9CM:312.31 MESH:D005715 NCI:C94335 OMIM:606349 UMLS_CUI:C0030662
				substance abuse IDs substance abuse DOID:302 MESH:D019966 NCI:C16522 UMLS_CUI:C0013146

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 2 alleles in 3 genetic backgrounds
52 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

1
Targeted

8
Genomic Mutations

1 involving Drd4
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutants are less active in open field tests and have reduced responses to novelty. However, mice exhibit locomotor supersensitivity to ethanol, cocaine, and methamphetamine.

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All GO Annotations

107
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

964
Tissues

169
cDNA Data

17
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase drd4

ZFIN drd4a, drd4b

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All Sequences

36
RefSeq

6
UniProt

1
CCDS

CCDS22007.1

Ensembl

ENSMUSG00000025496 (Evidence)
NCBI Gene

13491

			Length	Strain/Species	Flank
genomic	13491	NCBI Gene Model \| MGI Sequence Detail	2938	C57BL/6J	± kb
transcript	NM_007878	RefSeq \| MGI Sequence Detail	1278	ZRU/MplStud
polypeptide	P51436	UniProt \| EBI \| MGI Sequence Detail	387	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001179 D(4) dopamine receptor

(term hierarchy)
PDB

6IQL
InterPro Domains

IPR002185 Dopamine D4 receptor

IPR000929 Dopamine receptor family

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

P51436 1 site

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All nucleic 25

Genomic 3

cDNA 17

Primer pair 5

Microarray probesets 4

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MGD-MRK-8894, MGD-MRK-8899, MGI:2142209

Summaries

All 106

Developmental Gene Expression 11

Gene Ontology 14

Phenotypes 52
Earliest

J:22009 Rao PA, et al., Allelic variation in the D4 dopamine receptor (DRD4) gene does not predict response to clozapine. Arch Gen Psychiatry. 1994 Nov;51(11):912-7
Latest

J:353790 D'Souza SP, et al., Developmental control of rod number via a light-dependent retrograde pathway from intrinsically photosensitive retinal ganglion cells. Dev Cell. 2024 Aug 8;

TSS for Drd4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69943	Chr7:140871901-140871946 (+)	-7 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24