Drd5 MGI Mouse Gene Detail - MGI:94927

Symbol

Drd5
Name

dopamine receptor D5
Synonyms

D5R, Drd1b, DRD1b, Drd-5, Gpcr1

Feature Type

protein coding gene
IDs

MGI:94927
NCBI Gene: 13492
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr5:38476742-38479868 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 20.40 cM
Mapping Data

13 experiments

SNPs within 2kb

185 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_94927	protein coding gene	Chr5:38476710-38479868 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029511	protein coding gene	Chr5:36728085-36731236 (+)
A/J	MGP_AJ_G0029477	protein coding gene	Chr5:35503448-35506601 (+)
AKR/J	MGP_AKRJ_G0029427	protein coding gene	Chr5:36835560-36838715 (+)
BALB/cJ	MGP_BALBcJ_G0029488	protein coding gene	Chr5:35992616-35995768 (+)
C3H/HeJ	MGP_C3HHeJ_G0029211	protein coding gene	Chr5:36824422-36827572 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029942	protein coding gene	Chr5:38670885-38674036 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027180	protein coding gene	Chr5:33176364-33179526 (+)
CAST/EiJ	MGP_CASTEiJ_G0028619	protein coding gene	Chr5:35995044-35998203 (+)
CBA/J	MGP_CBAJ_G0029178	protein coding gene	Chr5:39587686-39593509 (+)
DBA/2J	MGP_DBA2J_G0029325	protein coding gene	Chr5:35624311-35627462 (+)
FVB/NJ	MGP_FVBNJ_G0029284	protein coding gene	Chr5:35107126-35110284 (+)
LP/J	MGP_LPJ_G0029411	protein coding gene	Chr5:37177893-37181044 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029314	protein coding gene	Chr5:40307057-40310208 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029975	protein coding gene	Chr5:36323406-36326552 (+)
PWK/PhJ	MGP_PWKPhJ_G0028343	protein coding gene	Chr5:34791132-34794271 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028177	protein coding gene	Chr5:35772689-35775836 (+)
WSB/EiJ	MGP_WSBEiJ_G0028700	protein coding gene	Chr5:36403546-36406694 (+)

Human Ortholog

DRD5, dopamine receptor D5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DRD5, dopamine receptor D5
Synonyms

DBDR, DRD1B, DRD1L2
Links

HGNC:3026

NCBI Gene ID: 1816

neXtProt AC: NX_P21918

UniProt: P21918
Chr Location

4p16.1; chr4:9781634-9784009 (+) GRCh38

MGI Vertebrate Homology

Drd5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DRD5
Gene Tree

Drd5

Diseases

2 with human DRD5 associations

				Human Disease	Mouse Models
				attention deficit hyperactivity disorder IDs attention deficit hyperactivity disorder DOID:1094 DOID:1093 EFO:0003888 ICD9CM:314.8 MESH:D001289 OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312 UMLS_CUI:C0041671
				blepharospasm IDs blepharospasm DOID:529 ICD10CM:G24.5 ICD9CM:333.81 MESH:D001764 NCI:C118723 UMLS_CUI:C0005747

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

14 phenotypes from 5 alleles in 7 genetic backgrounds
3 phenotypes from multigenic genotypes
53 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

2
Spontaneous

1
Targeted

7
Genomic Mutations

6 involving Drd5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice develop hypertension and exhibit elevated blood pressure caused by increased sympathetic tone. Mice homozygous for another knock-out allele exhibit increased methamphetamine-induced ambulatory activity.

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All GO Annotations

61
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1019
Tissues

105
cDNA Data

12
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase drd5

ZFIN drd5a

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All Sequences

34
RefSeq

2
UniProt

2
CCDS

CCDS19255.1

Ensembl

ENSMUSG00000039358 (Evidence)
NCBI Gene

13492

			Length	Strain/Species	Flank
genomic	13492	NCBI Gene Model \| MGI Sequence Detail	3127	C57BL/6J	± kb
transcript	NM_013503	RefSeq \| MGI Sequence Detail	3127	ZRU/MplStud
polypeptide	Q8BLD9	UniProt \| EBI \| MGI Sequence Detail	478	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001176 D(1B) dopamine receptor

(term hierarchy)
InterPro Domains

IPR000497 Dopamine D5 receptor

IPR000929 Dopamine receptor family

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

Q8BLD9 1 site

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All nucleic 18

Genomic 1

cDNA 13

Primer pair 4

Microarray probesets 1

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MGD-MRK-16351, MGD-MRK-16359, MGD-MRK-8895, MGD-MRK-8900

Summaries

All 114

Developmental Gene Expression 10

Diseases 1

Gene Ontology 17

Phenotypes 53
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:331618 Li J, et al., D1/D5 Dopamine Receptors and mGluR5 Jointly Enable Non-Hebbian Long-Term Potentiation at Sensory Synapses onto Lamina I Spinoparabrachial Neurons. J Neurosci. 2022 Jan 19;42(3):350-361

TSS for Drd5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr1469	Chr5:38477574-38477577 (+)	834 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24