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Ubl4a Gene Detail
Summary
  • Symbol
    Ubl4a
  • Name
    ubiquitin-like 4A
  • Synonyms
    DXHXS254E, DXS254Eh, Gdx, Ubl4
  • Feature Type
    protein coding gene
  • IDs
    MGI:95049
    NCBI Gene: 27643
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:73409324-73412154 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 38.00 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95049
 protein coding gene ChrX:73409324-73416824 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035844
 protein coding gene ChrX:70171936-70179428 (-)
A/J MGP_AJ_G0035825
 protein coding gene ChrX:70350072-70359224 (-)
AKR/J MGP_AKRJ_G0035750
 protein coding gene ChrX:72251587-72259960 (-)
BALB/cJ MGP_BALBcJ_G0035810
 protein coding gene ChrX:69377368-69384866 (-)
C3H/HeJ MGP_C3HHeJ_G0035515
 protein coding gene ChrX:70644795-70652291 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036340
 protein coding gene ChrX:72337068-72344564 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033184
 protein coding gene ChrX:69416113-69423825 (-)
CAST/EiJ MGP_CASTEiJ_G0034806
 protein coding gene ChrX:56022281-56029757 (-)
CBA/J MGP_CBAJ_G0035490
 protein coding gene ChrX:74335709-74343205 (-)
DBA/2J MGP_DBA2J_G0035647
 protein coding gene ChrX:69811770-69819268 (-)
FVB/NJ MGP_FVBNJ_G0035591
 protein coding gene ChrX:69156334-69163831 (-)
LP/J MGP_LPJ_G0035732
 protein coding gene ChrX:70944067-70951559 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035629
 protein coding gene ChrX:76887546-76895043 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036362
 protein coding gene ChrX:69984977-69992468 (-)
PWK/PhJ MGP_PWKPhJ_G0034505
 protein coding gene ChrX:53983805-53991288 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034339
 protein coding gene ChrX:56894163-56901628 (-)
WSB/EiJ MGP_WSBEiJ_G0034947
 protein coding gene ChrX:69268489-69275979 (-)



Homology
more
  • Human Ortholog
    UBL4A, ubiquitin like 4A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBL4A, ubiquitin like 4A
  • Synonyms
    DX254E, DXS254E, G6PD, GDX, GET5, MDY2, TMA24, UBL4
  • Links
    NCBI Gene ID: 8266
    neXtProt AC: NX_P11441
    UniProt: P11441

  • Chr Location
    Xq28; chrX:154483717-154486615 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous or hemizygous for one allele exhibit no abnormal phenotype. Mice homozygous or hemizygous for a knock-out allele exhibit incomplete neonatal lethality with cyanosis, decreased body weight and impaired liver glycogen synthesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    3
  • cDNA Data
    6
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27643 NCBI Gene Model | MGI Sequence Detail 2831 C57BL/6J ±  kb
    transcript NM_145405 RefSeq | MGI Sequence Detail 2334 ZRU/MplStud  
    polypeptide P21126 UniProt | EBI | MGI Sequence Detail 157 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 13
      cDNA 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10052, MGD-MRK-9032, MGD-MRK-9206
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:9005 Brockdorff N, et al., Construction of a detailed molecular map of the mouse X chromosome by microcloning and interspecific crosses. EMBO J. 1987 Nov;6(11):3291-7
    • Latest
      J:319444 Yu C, et al., The Dispensable Roles of X-Linked Ubl4a and Its Autosomal Counterpart Ubl4b in Spermatogenesis Represent a New Evolutionary Type of X-Derived Retrogenes. Front Genet. 2021;12:689902
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory