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Epha2 Gene Detail
Summary
  • Symbol
    Epha2
  • Name
    Eph receptor A2
  • Synonyms
    Eck, Myk2, Sek-2, Sek2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95278
    NCBI Gene: 13836
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:141028551-141056695 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 73.67 cM, cytoband D-E
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    815 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95278
 protein coding gene Chr4:141028532-141056695 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029043
 protein coding gene Chr4:144348882-144376938 (+)
A/J MGP_AJ_G0029002
 protein coding gene Chr4:138067526-138095628 (+)
AKR/J MGP_AKRJ_G0028954
 protein coding gene Chr4:142051537-142081829 (+)
BALB/cJ MGP_BALBcJ_G0029026
 protein coding gene Chr4:138760126-138788312 (+)
C3H/HeJ MGP_C3HHeJ_G0028740
 protein coding gene Chr4:142427269-142456757 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029467
 protein coding gene Chr4:149382805-149410824 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026738
 protein coding gene Chr4:130980717-131008877 (+)
CAST/EiJ MGP_CASTEiJ_G0028172
 protein coding gene Chr4:140691600-140723999 (+)
CBA/J MGP_CBAJ_G0028704
 protein coding gene Chr4:153710920-153742865 (+)
DBA/2J MGP_DBA2J_G0028854
 protein coding gene Chr4:138470445-138499358 (+)
FVB/NJ MGP_FVBNJ_G0028821
 protein coding gene Chr4:137574029-137603912 (+)
LP/J MGP_LPJ_G0028953
 protein coding gene Chr4:144366970-144396454 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028847
 protein coding gene Chr4:157550755-157582148 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029505
 protein coding gene Chr4:142581796-142611774 (+)
PWK/PhJ MGP_PWKPhJ_G0027893
 protein coding gene Chr4:135357410-135385924 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027718
 protein coding gene Chr4:138389662-138418352 (+)
WSB/EiJ MGP_WSBEiJ_G0028250
 protein coding gene Chr4:142864480-142892726 (+)



Homology
more
  • Human Ortholog
    EPHA2, EPH receptor A2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPHA2, EPH receptor A2
  • Synonyms
    ARCC2, CTPA, CTPP1, CTRCT6, ECK
  • Links
    NCBI Gene ID: 1969
    neXtProt AC: NX_P29317
    UniProt: P29317

  • Chr Location
    1p36.13; chr1:16124337-16156069 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Epha2 mouse models; 1 with human EPHA2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 5 alleles in 6 genetic backgrounds
    3 phenotypes from multigenic genotypes
    3 images
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal angiogenesis. Mice homozygous for a gene trap allele exhibit increased incidence of chemically-induced tumors, increased metastatic potential, and age-related cataracts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    123
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1094
  • Tissues
    209
  • cDNA Data
    64
  • Literature Summary
    51
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006445 Ensembl Gene Model | MGI Sequence Detail 28145 C57BL/6J ±  kb
    transcript ENSMUST00000006614 Ensembl | MGI Sequence Detail 3913 Not Applicable  
    polypeptide ENSMUSP00000006614 Ensembl | MGI Sequence Detail 977 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000007122 ephrin type-A receptor 2
      (term hierarchy)
    • PDB
      5ZRX
    • EC
      2.7.10.1
    • InterPro Domains
      IPR001090 Ephrin receptor ligand binding domain
      IPR027936 Ephrin receptor, transmembrane domain
      IPR016257 Ephrin receptor type-A /type-B
      IPR050449 Ephrin receptor tyrosine kinases
      IPR034263 Ephrin type-A receptor 2, ligand binding domain
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR008979 Galactose-binding-like domain superfamily
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
    • GlyGen
      Q03145 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 66
      Primer pair 5
      Other 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9293, MGI:2140587
    References
    more
    • Summaries
      All 169
      Developmental Gene Expression 51
      Diseases 1
      Gene Ontology 19
      Phenotypes 58
    • Earliest
      J:19013 Lindberg RA, et al., cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. Mol Cell Biol. 1990 Dec;10(12):6316-24
    • Latest
      J:358430 Horner JL, et al., Canonical ligand-dependent and non-canonical ligand-independent EphA2 signaling in the eye lens of wild-type, knockout, and aging mice. Aging (Albany NY). 2024 Oct 25;16(20):13039-13075
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory